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Antioxidant, Anticancer and Tyrosinase Inhibition Activities of Extracts from Rhododendron mucronulatum T.  

An, Bong-Jeun (Department of Cosmeceutical Science, Daegu Haany University)
Lee, Chang-Eon (Department of Cosmeceutical Science, Daegu Haany University)
Son, Jun-Ho (Department of Cosmeceutical Science, Daegu Haany University)
Lee, Jin-Young (Department of Cosmeceutical Science, Daegu Haany University)
Choi, Gui-Hyang (Department of Cosmeceutical Science, Daegu Haany University)
Park, Tae-Soon (Department of Cosmeceutical Science, Daegu Haany University)
Publication Information
Applied Biological Chemistry / v.48, no.3, 2005 , pp. 280-284 More about this Journal
Abstract
Several biological activities of Rhododendron mucronulatum were investigated. The electron donating abilities of ethanol extracts of Rhododendron mucronulatum were more than 90% at 100 ppm, 500 ppm and 1,000 ppm. Xanthine oxidase was inhibition about 46% by the ethanol extracts of R. mucronulatum at 500 ppm 48% of tyrosinase activity relating to skin-whitening was shown at 1,000 ppm. Uniquely, the anti-microbial effects of water extract and ethanol extract were shown only on Staphylococcus aureus. The water extract 1 mg/disc showed the higher activity than ethanol extract. The growth inhibition effect of each sample on lung cancer (A549) and melanoma (B16F10) cell lines were over 70% at 1,000 ppm, while the effects on the melanoma (G361) and liver cancer (HepG2) were about 50% at the same concentration.
Keywords
Rhododendron mucronulatum; physiological activities; whitening;
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