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http://dx.doi.org/10.14373/JKDA.2021.27.4.248

The Effect of Dementia Prevention Nutrition Program Using MIND Diet on the Changes in Cognitive Function of the Elderly with High-Dementia Risks  

Song, Jaeeun (Dept. of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University)
Choi, Seong Hye (Dept. of Neurology, Inha University Hospital)
Hong, Chang Hyung (Dept. of Psychiatry, Ajou University School of Medicine)
Jeong, Jee Hyang (Dept. of Neurology, Ewha Womans University School of Medicine)
Moon, So Young (Dept. of Neurology, Ajou University School of Medicine)
Na, Hae Ri (Dept. of Neurology, Bobath Memorial Hospital)
Park, Hee Kyung (Dept. of Neurology, Ewha Womans University School of Medicine)
Park, Yoo Kyoung (Dept. of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University)
Publication Information
Journal of the Korean Dietetic Association / v.27, no.4, 2021 , pp. 248-262 More about this Journal
Abstract
This study examined the effect of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet of the Korean multi-domain dementia prevention program on the cognitive functions of the elderly with dementia risk factors. We developed the program including nutrition, exercise, cognitive training, vascular disease prevention, and motivation. One- hundred and fifty-three participants aged 60~79 years with at least 1 dementia risk factor were randomly assigned in a 1:1:1 ratio to the facility-based intervention (FMI), home-based intervention (HMI), and the control group. The nutrition education program consisted of 10 classes over 24 weeks: the FMI received 7 group sessions and three 1:1 sessions, the HMI received 4 group sessions and three 1:1 sessions with 3 homework sessions. The Nutrition Quotient for Elderly (NQ-E) and the Mini Nutritional Assessment (MNA) were used to evaluate nutritional status. The Repeatable Battery for the Assessment Neuropsychological Status (RBANS), Korean Mini-Mental State Examination (K-MMSE), and the Cognitive Complaint Interview (CCI) were used to evaluate cognitive functions. A total of 136 people completed the program with an 11.1% dropout rate. The NQ-E (P=0.009) and RBANS (P=0.001) scores significantly increased in the FMI (N=45) and HMI (N=49) groups compared to the control group (N=42) after the study. The changes in the score of MNA and CCI did not differ significantly between groups. In conclusion, the nutritional intervention which focused on the MIND diet as a part of a multi-domain intervention program had a positive effect on the improvement of healthy eating habits and cognitive function scores in the high-risk dementia group.
Keywords
Mediterranean-DASH Intervention for Neurodegenerative Delay diet; dementia; Nutrition Quotient for Elderly; cognitive function;
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1 Lee JS, Kang MJ, Nam HJ, Kim YJ, Lee OJ, Kim KW. Korean dementia observatory 2019. Seoul: National Institute of Dementia; 2020 Feb. Report No.: NIDR-1902-0028.
2 Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS (2006): Associations of vegetable and fruit consumption with age-related cognitive change. Neurology 67(8):1370-1376   DOI
3 Thomas-Anterion C, Honore-Masson S, Laurent B (2006): The cognitive complaint interview (CCI). Psychogeriatrics 6(Suppl 1):S18-S22   DOI
4 Chin J, Park J, Yang SJ, Yeom J, Ahn Y, Baek MJ, Ryu HJ, Lee BH, Han NE, Ryu KH, Kang Y (2018): Re-standardization of the Korean-Instrumental Activities of Daily Living (K-IADL): clinical usefulness for various neurodegenerative diseases. Dement Neurocogn Disord 17(1): 11-22   DOI
5 Chung MJ, Kwak TK, Kim HY, Kang MH, Lee JS, Chung HR, Kwon S, Hwang JY, Choi YS (2018): Development of NQ-E, Nutrition Quotient for Korean elderly: item selection and validation of factor structure. J Nutr Health 51(1): 87-102   DOI
6 Ham SW, Kim KH (2020): Evaluation of the dietary quality and nutritional status of elderly people using the Nutrition Quotient for Elderly (NQ-E) in Seoul. J Nutr Health 53(1): 68-82   DOI
7 Kang Y (2006): A normative study of the Korean Mini-Mental State Examination (K-MMSE) in the elderly. Korean J Psychol 25(2):1-12
8 Kivipelto M, Mangialasche F, Ngandu T (2018): Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nat Rev Neurol 14(11):653-666   DOI
9 Martins RN, Anstey KJ, Baker LD, Barin E, Dias CB, Brown BM, Burnham SC, Chatterjee P, Chen J, Clarnette R, Deang K, England T, Fuller S, Gardener SL, Gleason A, Grieve S, Hillebrandt H, Ireland C, Kenny P, Kivipelto M, Mobbs R, Naismith SL, Peters R, Rainey-Smith SR, Raman R, Savage G, Sohrabi H, Shah TM, Steiner GZ, Taddei K, Thompson B, Villemagne VLL, Yates PA (2020): AU-ARROW (Australia): world-wide FINGERS network: the first global network of multidomain dementia prevention trials. Alzheimers Dement 16(S10):e046955
10 Navratilova M, Jarkovsky J, Ceskova E, Leonard B, Sobotka L (2007): Alzheimer disease: malnutrition and nutritional support. Clin Exp Pharmacol Physiol 34(Suppl 1):S11-S13   DOI
11 Omar SH (2019): Mediterranean and MIND diets containing olive biophenols reduces the Prevalence of Alzheimer's disease. Int J Mol Sci 20(11):2797   DOI
12 Toman J, Klimova B, Valis M (2018): Multidomain lifestyle intervention strategies for the delay of cognitive impairment in healthy aging. Nutrients 10(10):1560   DOI
13 Park HK, Jeong JH, Moon SY, Park YK, Hong CH, Na HR, Song HS, Lee SM, Choi M, Park KW, Kim BC, Cho SH, Chun BO, Choi SH (2020): South Korean study to prevent cognitive impairment and protect brain health through lifestyle intervention in at-risk elderly people: protocol of a multicenter, randomized controlled feasibility trial. J Clin Neurol 16(2):292-303   DOI
14 Park JO, Koo BH, Kim JY, Bai DS, Chang MS, Kim OL (2021): The Korean repeatable battery for the assessment of neuropsychological status-update: psychiatric and neurosurgery patient sample validity. J Korean Neurosurg Soc 64(1):125-135   DOI
15 Yaffe K, Barnes DE, Rosenberg D, Dublin S, Kaup AR, Ludman EJ, Vittinghoff E, Peltz CB, Renz AD, Adams KJ, Larson EB (2019): Systematic Multi-domain Alzheimer's Risk Reduction Trial (SMARRT): study protocol. J Alzheimers Dis 70(s1):S207-S220   DOI
16 Devore EE, Kang JH, Breteler MM, Grodstein F (2012): Dietary intakes of berries and flavonoids in relation to cognitive decline. Ann Neurol 72(1):135-143   DOI
17 Cho JH (2014): A comparison of cognitive impairment level according to characteristics and MMSE-DS of the elderly. Masters degree thesis. Korea National Open University. p.47
18 Choi SH, Shim YS, Ryu SH, Ryu HJ, Lee DW, Lee JY, Jeong JH, Han SH (2011): Validation of the literacy independent cognitive assessment. Int Psychogeriatr 23(4):593-601   DOI
19 Deckers K, van Boxtel MP, Schiepers OJ, de Vugt M, Munoz Sanchez JL, Anstey KJ, Brayne C, Dartigues JF, Engedal K, Kivipelto M, Ritchie K, Starr JM, Yaffe K, Irving K, Verhey FR, Kohler S (2015): Target risk factors for dementia prevention: a systematic review and Delphi consensus study on the evidence from observational studies. Int J Geriatr Psychiatry 30(3):234-246   DOI
20 Han C, Jo SA, Jo I, Kim E, Park MH, Kang Y (2008): An adaptation of the Korean mini-mental state examination (K-MMSE) in elderly Koreans: demographic influence and population-based norms (the AGE study). Arch Gerontol Geriatr 47(3):302-310   DOI
21 Hong JY, Lee Y, Sunwoo MK, Sohn YH, Lee PH (2018): Subjective cognitive complaints and objective cognitive impairment in Parkinson's disease. J Clin Neurol 14(1):16-21   DOI
22 Kim MS, Kim SK, Kim SH, Lee YH, Oh GJ (2018): The Nutrition Quotient for Elderly (NQ-E) and nutritional status of community-dwelling older adults in Gochang area. Korean Association of Human Ecology. Daejeon. p.127
23 Kim SS, Jo HM (2018): Dementia prevention programs among Koreans: a systematic review. J Korea Contents Assoc 18(4):89-98   DOI
24 Morris MC (2004): Diet and Alzheimer's disease: what the evidence shows. MedGenMed 6(1):48
25 Lee HO, Lee JS, Shin JW, Lee GJ (2010): Nutrition assessment of older subjects in a health care center by MNA (Mini Nutritional Assessment). J Korean Diet Assoc 16(2): 122-132
26 Kivipelto M, Solomon A, Ahtiluoto S, Ngandu T, Lehtisalo J, Antikainen R, Backman L, Hanninen T, Jula A, Laatikainen T, Lindstrom J, Mangialasche F, Nissinen A, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H (2013): The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): study design and progress. Alzheimers Dement 9(6):657-665   DOI
27 Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT (2015b): MIND diet associated with reduced incidence of Alzheimer's disease. Alzheimers Dement 11(9): 1007-1014   DOI
28 Oh E, Kang Y, Shin JH, Yeon BK (2010): A validity study of K-MMSE as a screening test for dementia: comparison against a comprehensive neuropsychological evaluation. Dement Neurocogn Disord 9(1):8-12
29 Liu X, Morris MC, Dhana K, Ventrelle J, Johnson K, Bishop L, Hollings CS, Boulin A, Laranjo N, Stubbs BJ, Reilly X, Carey VJ, Wang Y, Furtado JD, Marcovina SM, Tangney C, Aggarwal NT, Arfanakis K, Sacks FM, Barnes LL (2021): Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study: rationale, design and baseline characteristics of a randomized control trial of the MIND diet on cognitive decline. Contemp Clin Trials 102:106270   DOI
30 Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, Ballard C, Banerjee S, Burns A, Cohen-Mansfield J, Cooper C, Fox N, Gitlin LN, Howard R, Kales HC, Larson EB, Ritchie K, Rockwood K, Sampson EL, Samus Q, Schneider LS, Selbaek G, Teri L, Mukadam N (2017): Dementia prevention, intervention, and care. Lancet 390 (10113):2673-2734   DOI
31 Morris MC, Tangney CC, Wang Y, Barnes LL, Bennett D, Aggarwal N (2014): O2-02-04: MIND diet score more predictive than DASH or Mediterranean diet scores. Alzheimers Dement 10(4S_Part_2):P166
32 Morris MC, Tangney CC, Wang Y, Sacks FM, Barnes LL, Bennett DA, Aggarwal NT (2015a): MIND diet slows cognitive decline with aging. Alzheimers Dement 11(9):1015-1022   DOI
33 Alonso A, Jacobs DR Jr, Menotti A, Nissinen A, Dontas A, Kafatos A, Kromhout D (2009): Cardiovascular risk factors and dementia mortality: 40 years of follow-up in the Seven Countries Study. J Neurol Sci 280(1-2):79-83   DOI
34 Ngandu T, Lehtisalo J, Solomon A, Levalahti E, Ahtiluoto S, Antikainen R, Backman L, Hanninen T, Jula A, Laatikainen T, Lindstrom J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M (2015): A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet 385(9984):2255-2263   DOI
35 Agarwal P, Wang Y, Buchman AS, Holland TM, Bennett DA, Morris MC (2018): MIND diet associated with reduced incidence and delayed progression of parkinsonism in old age. J Nutr Health Aging 22(10):1211-1215   DOI