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http://dx.doi.org/10.9718/JBER.2020.41.1.62

Stereocomplex Poly(lactic acid) Discoidal Microparticles for Sustained Drug Release  

Park, Chaewon (Department of Biomedical Engineering, Yonsei University)
Park, Sanghyo (Department of Biomedical Engineering, Yonsei University)
Kim, Woo Cheol (Department of Biomedical Engineering, Yonsei University)
Key, Jaehong (Department of Biomedical Engineering, Yonsei University)
Publication Information
Journal of Biomedical Engineering Research / v.41, no.1, 2020 , pp. 62-66 More about this Journal
Abstract
Controlled drug release is important for effective treatment of cancer. Poly(DL-lactide-co-glycolide) acid (PLGA) is a Food and Drug Administration (FDA) approved polymer and have been extensively studied as drug delivery carriers with biodegradable and biocompatible properties. However, PLGA drug delivery carriers are limited due to the initial burst release of drug. Certain drugs require an early rapid release, but in many cases the initial rapid release can be inefficient, reducing therapeutic effects and also increasing side effects. Therefore, sustained release is important for effective treatment. Poly Lactic Acid stereo complex (PLA SC) is resistant to hydrolysis and has high stability in aqueous solutions. Therefore, in this work, PLGA based discoidal polymeric particles are modified by Poly Lactic Acid stereocomplex (PLAsc DPPs). PLAsc DPPs are 3 ㎛ in diameter, also showing a relatively sustained release profile. Fluorescein 5(6)-isothiocyanate (FITC) released from PLAsc DPPs was continuously observed until 38 days, which showed the initial release of FITC from PLAsc DPPs was about 3.9-fold reduced as compared to PLGA based DPPs at 1 hour.
Keywords
Drug delivery; Carriers; PLA stereo complex; Sustained release;
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