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http://dx.doi.org/10.9718/JBER.2019.40.2.39

Effects of Anticancer Drug Delivery based on Microbubble and Microbubble-Nanoparticle Complex using Low-Intensity Focused Ultrasound in Breast Cancer Animal Model  

Baek, Hee Gyu (Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation)
Ha, Shin-Woo (IMGT Co., LTD)
Huh, Hyungkyu (Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation)
Jung, Byeongjin (Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation)
Han, Mun (Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation)
Moon, Hyungwon (Department of Radiology, Seoul National University College of Medicine)
Kim, Sangkyun (Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation)
Lee, Hak Jong (IMGT Co., LTD)
Park, Juyoung (Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation)
Publication Information
Journal of Biomedical Engineering Research / v.40, no.2, 2019 , pp. 39-47 More about this Journal
Abstract
Ultrasound sonication along with microbubble (MB) could enhance drug delivery to promote the absorption of anticancer drugs into cancers in a noninvasive and targeted manners. In this study, we verify the acute drug delivery enhancement (within an hour) of two representative focused ultrasound driven drug delivery enhancement methods (MB and Doxorubicin-coated Nanoparticle complex (MB-NP) based). Experiments were conducted using in vivo mouse model with MDA-MB-231 breast cancer cell line. Ultrasound generated by single-element 1 MHz focused ultrasound transducer was delivered in pulsed sonication consisted of 0.125 msec bursts at a pulse repetition frequency of 2 Hz for 20 seconds without a significant increase in local temperature (less than $0.1^{\circ}C$) or hemorrhage. Doxorubicin concentrations in tumors were improved by 1.97 times in the case of MB-NP, and 1.98 times by using Doxorubicin and MB separately. These results indicate anticancer drug delivery based on MB and MB-NP can significantly improve the effect of anticancer drugs delivered to tumors in a short time period by using low-intensity focused ultrasound.
Keywords
Breast cancer; Anticancer drug delivery; Focused ultrasound; Microbubble; Microbubble-Nanoparticle complex;
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