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http://dx.doi.org/10.9718/JBER.2018.39.1.1

The Effect of Micro-current Electrical Therapy on Muscle Atrophy and Delayed Wound Healing Process Induced Rat Caused by Traumatic Peripheral Nerve Injury  

Lee, Hana (Department of Biomedical Engineering, Yonsei University)
Kim, Seohyun (Department of Biomedical Engineering, Yonsei University)
Hwang, Donghyun (Department of Biomedical Engineering, Yonsei University)
Yoo, Lee (Department of Biomedical Engineering, Yonsei University)
Yu, Jihee (Department of Biomedical Engineering, Yonsei University)
Kim, Minju (Department of Biomedical Engineering, Yonsei University)
Cho, Seungkwan (Cellogin Inc.)
Kim, Han Sung (Department of Biomedical Engineering, Yonsei University)
Publication Information
Journal of Biomedical Engineering Research / v.39, no.1, 2018 , pp. 1-9 More about this Journal
Abstract
This study was carried out to evaluate the effect of micro-current therapy on muscle atrophy and delayed wound healing process caused by traumatic peripheral nerve injury. For this, twenty-five 5-week-old Sprague Dawley rat were used and assigned to five groups including the normal group (NOR, n=5), the wound group (WD, n=5), the wounded and treated with micro-current electrical therapy group (WD+MET, n=5), the sciatic nerve denervated and wounded group (WD+DN, n=5), and the sciatic nerve denervated, wounded and treated with micro-current electrical therapy group (WD+DN+MET, n=5). In order to assess the changes in length of incisional wound for 12 days and the muscle volume for 2 weeks, the ImageJ analysis of macroscopic analysis and micro-CT data were obtained and analyzed. As a result, significant delay in the process in wound healing were observed and micro-current therapy suppress the postponement of healing process. Furthermore, there were significant changes in muscle volume between electrically treated group and non-treated group. These result shows that electrical stimulation may improve the delayed healing process and muscle atrophy at once.
Keywords
Traumatic peripheral nerve injury; Muscle atrophy; Wound healing; Micro-current electrical therapy; Micro-CT;
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Times Cited By KSCI : 3  (Citation Analysis)
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