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http://dx.doi.org/10.9718/JBER.2015.36.6.291

Studies on Osmotically Driven Drug Infusion Pump Under the Change in Body-Simulating Environment  

Yoon, Chul Whan (Chungdam High School)
Ahn, Jae Hong (Chungdam High School)
Park, Doh (Chungdam High School)
Lee, Jae Yeon (Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University)
Park, Chun Gwon (Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University)
Park, Min (Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University)
Choy, Young Bin (Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University)
Publication Information
Journal of Biomedical Engineering Research / v.36, no.6, 2015 , pp. 291-295 More about this Journal
Abstract
Various types of implantable drug delivery devices have attracted significant attention for several decades to improve drug bioavailability and reduce side effects, thus enhancing therapeutic efficacy and patients' compliance. However, when implanted into the body, the devices may be influenced by the changes in physiological condition, such as temperature, pH or ionic concentration. Thus, the drug release rates could be also altered concurrently. Therefore, in this work, we employed an implantable ALZET$^{(R)}$ Osmotic Pump, which has been widely used to locally deliver various therapeutic agents and examined the effect of pH, temperature and ionic concentration on its drug release rate. For this, we performed in vitro cell tests to simulate the condition of local tissues influenced by the altered drug release rates, where we used diclofenac sodium as a model drug.
Keywords
drug delivery; osmotic pump; pH; temperature; ionic concentration;
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Times Cited By KSCI : 1  (Citation Analysis)
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