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http://dx.doi.org/10.9718/JBER.2015.36.5.198

Estimation of Cardiac Pumping Performance according to the Ventricular Electrical Activation Time Distribution by Using Physiome Model  

Kim, Hyeong-Gyun (Department of Radiological Science, Far East University)
Lim, Ki Moo (Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology)
Publication Information
Journal of Biomedical Engineering Research / v.36, no.5, 2015 , pp. 198-203 More about this Journal
Abstract
The purpose of the study is to examine the effects of pacemaker location on cardiac pumping efficacy theoretically. We used a three-dimensional finite element cardiac electromechanical model of canine ventricles with models of the circulatory system. Electrical activation time for normal sinus rhythm and artificial pacing in apex, left ventricular free wall, and right ventricular free wall were obtained from electrophysiological model. We applied the electrical activation time maps to the mechanical contraction model and obtained cardiac mechanical responses such as myocardial contractile ATP consumption, stroke work, stroke volume, ejection fraction, and etc. Among three artificial pacing methods, left ventricle pacing showed best performance in ventricular pumping efficacy.
Keywords
Cardiac electromechanical model; Electrical activation time; ATP consumption rate; Stroke work; Stroke volume;
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1 Cazeau S, Ritter P, Bakdach S, Lazarus A, Limousin M, Henao L, Mundler O, Daubert JC, and Mugica J, "Four chamber pacing in dilated cardiomyopathy," Pacing Clin Electrophysiol, vol. 17, no. 11 pt 2, pp. 1974-1979, 1994.   DOI
2 Lim KM, Hong SB, Lee BK, Shim EB, and Trayanova NA, "Computational analysis of the effect of valvular regurgitation on ventricular mechanics using a 3D electromechanics model," J Physiol Sci, vol. 65, no. 2, pp. 159-164, 2015.   DOI
3 Lim KM, Constantino J, Gurev V, Zhu R, Shim EB, and Trayanova NA, "Comparison of the effects of continuous and pulsatile left ventricular-assist devices on ventricular unloading using a cardiac electromechanics model," J Physiol Sci, vol. 62, no. 1, pp. 11-19, 2012.   DOI
4 Gurev V, Lee T, Constantino J, Arevalo H, and Trayanova NA, "Models of cardiac electromechanics based on individual hearts imaging data: image-based electromechanical models of the heart," Biomech Model Mechanobiol, vol. 10, no. 3, pp. 295-306, 2011.   DOI
5 Onate E, Rojek J, Taylor RL, and Zienkiewicz OC, "Finite calculus formulation for incompressible solids using linear triangles and tetrahedra," International Journal for Numerical Methods in Engineering, vol. 59, no. 11, pp. 1473-1500, 2004.   DOI
6 Plank G, Zhou L, Greenstein JL, Cortassa S, Winslow RL, O'Rourke B, and Trayanova NA, "From mitochondrial ion channels to arrhythmias in the heart: computational techniques to bridge the spatio-temporal scales," Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol. 366, no. 1879, pp. 3381- 3409, 2008.   DOI
7 Roberts DE and Scher AM, "Effect of tissue anisotropy on extracellular potential fields in canine myocardium in situ," Circulation Research, vol. 50, no. 3, pp. 342-351, 1982.   DOI
8 Foster AH, Gold MR, and McLaughlin JS, "Acute hemodynamic effects of atrio-biventricular pacing in humans," Ann Thorac Surg, vol. 59, no. 2, pp. 294-300, 1995.   DOI
9 Blanc JJ, Etienne Y, Gilard M, Mansourati J, Munier S, Boschat J, Benditt DG, and Lurie KG, "Evaluation of different ventricular pacing sites in patients with severe heart failure: results of an acute hemodynamic study," Circulation, vol. 96, no. 10, pp. 3273-3277, 1997.   DOI
10 Buckingham TA, Candinas R, Schlapfer J, Aebischer N, Jeanrenaud X, Landolt J, and Kappenberger L, "Acute hemodynamic effects of atrioventricular pacing at differing sites in the right ventricle individually and simultaneously," Pacing Clin Electrophysiol, vol. 20, no. 4 pt 1, pp. 909-915, 1997.   DOI
11 Rice JJ, Wang F, Bers DM, and De Tombe PP, "Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations," Biophysical journal, vol. 95, no. 5, pp. 2368-2390, 2008.   DOI
12 Guccione JM, Costa KD, and McCulloch AD, "Finite element stress analysis of left ventricular mechanics in the beating dog heart," Journal of biomechanics, vol. 28, no. 10, pp. 1167-1177, 1995.   DOI
13 Vetter FJ and McCulloch AD, "Three-dimensional stress and strain in passive rabbit left ventricle: a model study," annals of biomedical engineering, vol. 28, no. 7, pp. 781-792, 2000.   DOI
14 Usyk TP, LeGrice IJ, and McCulloch AD, "Computational model of three-dimensional cardiac electromechanics," Computing and visualization in science, vol. 4, no. 4, pp. 249-257, 2002.   DOI
15 O'Rourke B, Kass DA, Tomaselli GF, Kaab S, Tunin R, and Marban E, "Mechanisms of Altered Excitation-Contraction Coupling in Canine Tachycardia-Induced Heart Failure, I Experimental Studies," Circulation, vol. 84, no. 5, pp. 562- 570, 1999.   DOI
16 Durrer D, van Dam RT, Freud GE, Janse MJ, Meijler FL, and Arzbaecher RC, "Total excitation of the isolated human heart," Circulation, vol. 41, no. 6, pp. 899-912, 1970.   DOI