Browse > Article
http://dx.doi.org/10.9718/JBER.2013.34.3.111

A Study on Effects of EGCG and Design Parameter for Drug-Eluting Biodegradable Polymer Stents  

Jung, T.G. (Department of Nanomedical Engineering, BK21 Nano Fusion Technology Division, College of Nanoscience & Nanotechnology, Pusan National University)
Lee, J.H. (Department of Nanomedical Engineering, BK21 Nano Fusion Technology Division, College of Nanoscience & Nanotechnology, Pusan National University)
Lee, J.J. (Department of Nanomedical Engineering, BK21 Nano Fusion Technology Division, College of Nanoscience & Nanotechnology, Pusan National University)
Hyon, S.H. (Center for Fiber and Textile Science, Kyoto Institute of Technology)
Han, D.W. (Department of Nanomedical Engineering, BK21 Nano Fusion Technology Division, College of Nanoscience & Nanotechnology, Pusan National University)
Publication Information
Journal of Biomedical Engineering Research / v.34, no.3, 2013 , pp. 111-116 More about this Journal
Abstract
Finite element analysis(FEA) has been extensively applied in the analyses of biomechanical properties of stents. Geometrically, a closed-cell stent is an assembly of a number of repeated unit cells and exhibits periodicity in both longitudinal and circumferential directions. This study concentrates on various parameters of the FEA models for the analysis of drug-eluting biodegradable polymeric stents for application to the treatment of coronary artery disease. In order to determine the mechanical characteristics of biodegradable polymeric stents, FEA was used to model two different types of stents: tubular stents(TS) and helicoidal stents(HS). For this modeling, epigallocatechin-3-O-gallate (EGCG)-eluting poly[(L-lactide-co-${\varepsilon}$-caprolactone), PLCL] (E-PLCL) was chosen as drug-eluting stent materials. E-PLCL was prepared by blending PLCL with 5% EGCG as previously described. In addition, the effects of EGCG blending on the mechanical properties of PLCL were investigated for both types of stent models. EGCG did not affect tensile strength at break, but significantly increased elastic modulus of PLCL. It is suggested that FEA is a cost-effective method to improve the design of drug-eluting biodegradable polymeric stents.
Keywords
poly(L-lactide-co-${\varepsilon}$-caprolactone); epigallocatechin-3-O-gallate; finite element analysis; bio-degradable polymer stent; coronary artery disease;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 D.S. Baim., et al., "Management of restenosis within the Palmaz-Schatz coronary stent(the U.S. multicenter experience. The U.S. Palmaz-Schatz Stent Investigators," Am J Cardiol., vol. 71, no. 4, pp. 364-366, 1993.   DOI   ScienceOn
2 A. Alcocer., et al., "Clinical variables related with in-stent restenosis late regression after bare metal coronary stenting," Arch Cardiol Mex., vol. 76, no. 4, pp. 390-396, 2006.
3 C. Lally, F. Dolan, and P.J. Prendergast, "Cardiovascular stent design and vessel stresses: a finite element analysis," J Biomech., vol. 38, no. 8, pp. 1574-1581, 2005.   DOI   ScienceOn
4 D.S. Baim, and J.P. Carrozza, Jr., "Stent thrombosis. Closing in on the best preventive treatment. Circulation," vol. 95, no. 5, pp. 1098-1100, 1997.   DOI   ScienceOn
5 H.C. Lee, C.S. Kim, B.C. Pak, and B.J. Baek, "Hydrodynamic Characteristics of Self-expandable Graft Stents in Steady Flow," J. Biomed. Eng. Res., vol. 24, no. 1, pp. 37-44, 2003.   과학기술학회마을
6 Devsesh Kothwala, Ankur Raval, Annimesh Choubey, "Pachlitaxel Drug Delivery From Cardiovascular Stent," Trends Biomater. Artif. Organs, vol. 19, no. 2, pp. 88-92, 2006.
7 G.S. Frank, R.F. John, "Drug Eluting Coronary Stent : In Vitro Evaluation of Magnet Resonance Satery at 3 Tesla," Journal of Cardiovascular Magnetic Resonance, vol. 7, no. 2, pp. 415-419, 2005.   DOI
8 Etave, F., et al., "Mechanical properties of coronary stents determined by using finite element analysis," J Biomech., vol. 34, no. 8, pp. 1065-1075, 2001.   DOI   ScienceOn
9 H.H. Cho, D.W. Han. K. Matsumura, S. Tsutsumi, and S.H. Hyon, "The behavior of vascular smooth muscle cells and platelets onto epigallocatechin gallate-releasing poly(l-lactide-co-e-caprolactone) as stent-coating materials," Biomaterials, vol. 29, no. 7, pp. 884-893, 2008.   DOI   ScienceOn
10 D.W. Han, et al., "Development of epigallocatechin gallateeluting polymeric stent and its physicochemicall, biomechanical and biological evaluations," Biomed Mater, vol. 4, no. 4, pp. 044104, 2009.   DOI   ScienceOn
11 D.W. Han, et al., "Underlying mechanism for suppression of vascular smooth muscle cells by green tea polyphenol EGCG released from biodegradable polymers for stent application," J Biomed Mater Res A, vol. 95, no. 2, pp. 424-433, 2010.
12 D.W. Han, M.H. Lee, B.J. Kwon, H.L. Kim, S.H. Hyon, and J.C. Park., "Selective inhibitory effect of epigallocatechin-3-gallate on migration of vascular smooth muscle cells," Molecules. Nov. 19, vol. 15, no. 11, pp. 8488-8500, 2010.   DOI   ScienceOn
13 F. Ju, Z. Xia, and K. Sasaki, "On the finite element modelling of balloon-expandable stents," J Mech Behav Biomed Mater, vol. 1, no. 1, pp. 86-95, 2008.   DOI   ScienceOn
14 D. Martin, and F.J. Boyle, "Computational structural modelling of coronary stent deployment: a review," Comput Methods Biomech Biomed Engin., vol. 14, no. 4, pp. 331-48, 2011.   DOI   ScienceOn
15 H. Brauer, J. Stolpmann, H. Hallmann, R. Erbel, and A. Fischer, "Measurement and numerical simulation of the dilatation behaviour of coronary stents," Mat.-wiss. U. Werkstofftech, vol. 30, no. 12, pp. 876-885, 1999.   DOI
16 F. Etave, G. Finet, M. Boivin, J. -C. Boyer, G. Rioufol, and G. Thollet, "Mechanical properties of coronary stents determined by using finite element analysis," J. Biomech., vol. 34, no. 8, pp. 1065-1075, 2001.   DOI   ScienceOn
17 Sanjay A. Pujari, "Stent Biomechanics in Marginal Coronary Stenotic Arteries," International Journal of Recent Trends in Engineering, vol. 1, no. 2, 2009.
18 C. Dumoulin, and B. Cochelin, "Mechanical behaviour modelling of balloon-expandable stents," J Biomech., vol. 33, no. 11, pp. 1461-1470, 2000.   DOI   ScienceOn