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http://dx.doi.org/10.9718/JBER.2012.33.2.078

Alteration of Trabecular Bone Microarchitecure at Tibial Epiphysis due to Knee Joint Instability by Anterior Cruciate Ligament Rupture: Difference between Medial and Lateral Part  

Lee, Joo-Hyung (Department of Mechanical Engineering, Sejong University)
Chun, Keyoung-Jin (Gerontechnology R&D Group, Korea Institute of Industrial Technology)
Kim, Han-Sung (Department of Biomedical Engineering, Yonsei University)
Lim, Do-Hyung (Department of Mechanical Engineering, Sejong University)
Publication Information
Journal of Biomedical Engineering Research / v.33, no.2, 2012 , pp. 78-88 More about this Journal
Abstract
Knee joint instability by anterior cruciate ligament(ACL) rupture is allowing the abnormal loading condition at the tibial epiphysis locally, resulting in producing locally different bone bruise. The study examined difference between local alteration patterns of trabecular bone microarchitecture at medial and lateral parts of the tibial epiphysis by ACL rupture. Fourteen SD rats were divided into Control(CON; n = 7) and Anterior Cruciate Ligament Transection(ACLT; n = 7) groups. The tibial joints were then scanned by in vivo ${\mu}$-CT at 0, 4, and 8 weeks post-surgery. The results showed that alteration pattern on trabecular bone microarchitecture at medial part was significantly higher than that at lateral part of the tibial epiphysis in ACLT group from 0 to 8 weeks(P < 0.05). Tb.Th and Tb.Sp distributions were well corresponded with differences between aforementioned trabecular bone microarchitectural alteration pattens at medial and lateral parts of the tibial epiphysis in ACLT group from 0 to 8 weeks(P < 0.05). These findings suggest that the alteration patterns of trabecular bone microarchitecture should be locally and periodically considered, particularly with respect to the prediction of bone fracture risk by ACL rupture. Improved understanding of the alteration patterns at medial and lateral trabecular bone microarchitectures at the tibial epiphysis may assist in developing more targeted treatment interventions for knee joint instability secondary to ACL rupture.
Keywords
Knee Joint Instability; Anterial Cruciate Ligament Rupture; Tibial Epiphysis; Locally Different Microarchitectural Alteration Pattern; Bone Fracture Risk;
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1 L.Y. Griffin, J. Agel, M.J. Albohm, E.A. Arendt, R.W. Dick, W.E. Garrett, J.G. Garrick, T.E. Hewett, L. Huston, M.L. Ireland, R.J. Johnson, W.B. Kibler, S. Lephart, J.L. Lewis, T.N. Lindenfeld, B.R. Mandelbaum, P. Marchak, C.C. Teitz, and E.M. Wojtys, "Noncontact anterior cruciate ligament injuries: risk factors and prevention strategies," J Am Acad Orthop Surg, vol. 8, no. 3, pp. 141-150, 2000.   DOI
2 H. Roos, T. Adalberth, L. Dahlberg, and L.S. Lohmander, "Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age," Osteoarthritis Cartilage, vol. 3, no. 4, pp. 261-267, 1995.   DOI
3 C.E. Quatman, A. Kiapour, G.D. Myer, K.R. Ford, C.K. Demetropoulos, V.K. Goel, and T.E. Hewett, "Cartilage pressure distributions provide a footprint to define female anterior cruciate ligament injury mechanisms," Am J Sports Med, vol. 39, no. 8, pp. 1706-1713, 2011.   DOI
4 N. Manidakis, A. Dosani, R. Dimitriou, D. Stengel, S. Matthews, and P. Giannoudis, "Tibial plateau fractures: functional outcome and incidence of osteoarthritis in 125 cases," Int Orthop, vol. 34, no. 4, pp. 565-570, 2010.   DOI
5 P.A. Kaplan, C.W. Walker, R.F. Kilcoyne, D.E. Brown, D. Tusek, and R.G. Dussault, "Occult fracture patterns of the knee associated with anterior cruciate ligament tears: assessment with MR imaging," Radiology, vol. 183, no. 3, pp. 835- 838, 1992.   DOI
6 M.A. Rosen, D.W. Jackson, and P.E. Berger, "Occult osseous lesions documented by magnetic resonance imaging associated with anterior cruciate ligament ruptures," Arthroscopy, vol. 7, no. 1, pp. 45-51, 1991.   DOI
7 M. Bellido, L. Lugo, J.A. Roman-Blas, S. Castaneda, J.R. Caeiro, S. Dapia, E. Calvo, R. Largo, and G. Herrero-Beaumont, "Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis," Arthritis Res Ther, vol. 12, no. 4, pp. R152, 2010.   DOI
8 Y.H. Sniekers, F. Intema, F.P. Lafeber, G.J. van Osch, J.P. van Leeuwen, H. Weinans, and S.C. Mastbergen, "A role for subchondral bone changes in the process of osteoarthritis; a micro-CT study of two canine models," BMC Musculoskelet Disord, vol. 9, pp. 20, 2008.   DOI
9 S.K. Boyd, R. Muller, T. Leonard, and W. Herzog, "Longterm periarticular bone adaptation in a feline knee injury model for post-traumatic experimental osteoarthritis," Osteoarthritis Cartilage, vol. 13, no. 3, pp. 235-242, 2005.   DOI
10 T. Hayami, M. Pickarski, G.A. Wesolowski, J. McLane, A. Bone, J. Destefano, G.A. Rodan, and T. Duong le, "The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model," Arthritis Rheum, vol. 50, no. 4, pp. 1193- 1206, 2004.   DOI
11 S.K. Boyd, J.R. Matyas, G.R. Wohl, A. Kantzas, and R.F. Zernicke, "Early regional adaptation of periarticular bone mineral density after anterior cruciate ligament injury," J Appl Physiol, vol. 89, no. 6, pp. 2359-2364, 2000.   DOI
12 J. Leppala, P. Kannus, A. Natri, M. Pasanen, H. Sievanen, I. Vuori, and M. Jarvinen, "Effect of anterior cruciate ligament injury of the knee on bone mineral density of the spine and affected lower extremity: a prospective one-year follow-Up study," Calcif Tissue Int, vol. 64, no. 4, pp. 357-363, 1999.   DOI
13 D.D. McErlain, C.T. Appleton, R.B. Litchfield, V. Pitelka, J.L. Henry, S.M. Bernier, F. Beier, and D.W. Holdsworth, "Study of subchondral bone adaptations in a rodent surgical model of OA using in vivo micro-computed tomography," Osteoarthritis Cartilage, vol. 16, no. 4, pp. 458-469, 2008.   DOI
14 J.M. Williams, D.L. Felten, R.G. Peterson, and B.L. O'Connor, "Effects of surgically induced instability on rat knee articular cartilage," J Anat, vol. 134, no. Pt 1, pp. 103-109, 1982.
15 J.S. Day, M. Ding, J.C. van der Linden, I. Hvid, D.R. Sumner, and H. Weinans, "A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage," J Orthop Res, vol. 19, no. 5, pp. 914-918, 2001.   DOI   ScienceOn
16 R.C. Bray, M.R. Doschak, T.S. Gross, and R.F. Zernicke, "Physiological and mechanical adaptations of rabbit medial collateral ligament after anterior cruciate ligament transection," J Orthop Res, vol. 15, no. 6, pp. 830-836, 1997.   DOI
17 G. Wexler, D.E. Hurwitz, C.A. Bush-Joseph, T.P. Andriacchi, and B.R. Bach, Jr., "Functional gait adaptations in patients with anterior cruciate ligament deficiency over time," Clin Orthop Relat Res, no. 348, pp. 166-175, 1998.
18 M.P. Rogers, D.E. Trentham, W.J. McCune, B.I. Ginsberg, H.G. Rennke, P. Reich, and J.R. David, "Effect of psychological stress on the induction of arthritis in rats," Arthritis Rheum, vol. 23, no. 12, pp. 1337-1342, 1980.   DOI
19 M.M. Smith, and C.B. Little, "Experimental models of osteoarthritis" In: R.W. Moskowitz, R.D. Altman, M.C. Hochberg, J.A. Buckwalter, V.M. Goldberg, "Osteoarthritis: Diagnosis and Medical/Surgical Management", 4th edition, WB Saunders., Philadelpia, 2007, pp. 118.
20 S.C. Lee, H.K. Kim, I.K. Chun, M.H. Cho, and S.Y. Lee, "A Flat-Panel Detector Based Micro-Ct System: Performance Evaluation for Small-Animal Imaging", Phys Med Biol, vol 48, pp. 4173-4185, 2003.   DOI   ScienceOn