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http://dx.doi.org/10.9718/JBER.2010.31.2.114

Image Fusion of Lymphoscintigraphy and Real images for Sentinel Lymph Node Biopsy in Breast Cancer Patients  

Jeong, Chang-Bu (Biomedical Engineering Branch, Division of Basic & Applied Sciences, National Cancer Center)
Kim, Kwang-Gi (Biomedical Engineering Branch, Division of Basic & Applied Sciences, National Cancer Center)
Kim, Tae-Sung (Department of Nuclear Medicine and Research Institute, National Cancer Center)
Kim, Seok-Ki (Department of Nuclear Medicine and Research Institute, National Cancer Center)
Publication Information
Journal of Biomedical Engineering Research / v.31, no.2, 2010 , pp. 114-122 More about this Journal
Abstract
This paper presents a method that registers a lymphoscintigraphy to the real image captured by a CMOS camera, which helps surgeons to easily and precisely detect sentinel lymph nodes for sentinel lymph node biopsy in breast cancer patients. The proposed method consists of two steps: pre-matching and image registration. In the first step, we localize fiducial markers in a lymphoscintigraphy and a real image of a four quadrant bar phantom by using image processing techniques, and then determines perspective transformation parameters by matching with the corresponding marker points. In the second step, we register a lymphoscintigraphy to a real images of patients by using the perspective transformation of pre-matching. To examine the accuracy of the proposed method, we conducted an experiment with a chest mock-up with radioactive markers. As a result, the euclidean distance between corresponding markers was less than 3mm. In conclusion, the present method can be used to accurately align lymphoscintigraphy and real images of patients without attached markers to patients, and then provide useful anatomical information on sentinel lymph node biopsy.
Keywords
breast cancer; sentinel lymph node biopsy; lymphoscintigraphy; real image; image registration;
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Times Cited By KSCI : 5  (Citation Analysis)
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