Browse > Article
http://dx.doi.org/10.9718/JBER.2009.30.1.001

Developments of Small Animal Imaging Systems in Korea  

Lee, Soo-Yeol (Dept. of Biomedical Engineering, Kyung Hee University)
Publication Information
Journal of Biomedical Engineering Research / v.30, no.1, 2009 , pp. 1-9 More about this Journal
Abstract
Many types of small animal imaging modalities, like micro-CT, micro-PET, and micro-SPECT, have been recently developed worldwide. Small animal imaging systems are now recognized as indispensable tools to validate efficacy and safety of new drugs or new therapeutic methods using the animal disease models. With increasing demands for small animal imaging in biomedical research, multimodal small animal imaging systems, like micro-PET/CT or micro PET/MRI, are now also being developed. Small animal imaging with spatial resolution and sensitivity comparable to human imaging is quite challenging since laboratory small animals are much smaller than human beings. Research activities in Korea on small animal imaging systems are reviewed in this paper. In the field of micro-CT and micro-PET, many world-class technologies have been developed successfully in Korea. It is expected that the developed animal imaging system technologies can be used in the development of clinical imaging systems in Korea in the near future.
Keywords
micro-CT; micro-SPECT; micro-PET; small animal imaging;
Citations & Related Records
연도 인용수 순위
  • Reference
1 M.J. Paulus, H. Sari-Sarraf, S.S. Gleason, M. Bobrek, J.S. Hicks, D.K. Johnson, J.K. Behel, L.H. Thompson, and W.C. Allen, 'A new x-ray computed tomography system for laboratory mouse imaging,' IEEE. Trans. Nucl. Sci., vol. 46, pp. 558-564, 1999   DOI   ScienceOn
2 I.K. Chun, M.H. Cho, J.H. Park, and S.Y. Lee, 'In vivo trabecular thickness measurement in cancellous bones: longitudinal rat imaging studies,' Physio. Meas., vol. 27, pp. 695-702, 2006   DOI   ScienceOn
3 S.M. Jorgensen, O. Demirkaya, and E.L. Ritman, 'Three-dimensional imaging of vasculature and parenchyma in intact rodent organs with x-ray micro-CT,' Am. J. Physiol., vol. 275, pp. H1103-1114, 1998
4 D.W. Townsend, 'Multimodality imaging of structure and function,' Phys. Med. Biol., vol. 53, pp. R1-R39, 2008   DOI   ScienceOn
5 J. H. Jung, Y. Choi, K.J. Hong, B.J. Min, W.H, and J.H. Kang, 'Recent advances in nuclear medicine imaging instrumentation,' Nucl. Med. Mol. Imaging, vol. 42, pp.1-14, 2008
6 L.A. Feldkamp, L.C. Davis, and J.W. Kress, 'Practical conebeam algorithm,' J. Opt Soc. Am. A, vol. 1, pp. 612-619, 1984   DOI
7 C. Catana, Y. Wu, M.S. Judenhofer, J. Qi, B.J. Pichler, and S.R. Cherry, 'Simultaneous acquisition of multislice PET and MR images: Initial results with a MR- compatible PET scanner,' J. Nucl. Med. vol. 47, pp. 1968-76, 2006
8 R.D. Kapadia, G.B. Stroup, A.M. Badger, B. Koller, J.M. Levin, R.W. Coatney, R.A. Dodds, X. Liang, M.W. Lark, and M. Gowen, 'Application of micro-CT and MR microscopy to study pre-clinical models of osteoporosis and osteoarthritis,' Technol. Health Care, vol. 6, pp. 361-372, 1998
9 T.F. Massoud, and S.S. Gambhir, 'Molecular imaging in living subject: seeing fundamental biological processes in a new light,' Genes & Development, vol. 17, pp. 545-580, 2003   DOI   ScienceOn
10 T.Y. Song, Y. Choi, J.H. Jung, B.J. Min, K.J. Hong, Y.S. Choe, et al. 'Performance vamelioration for small animal SPECT using optimized pinhole collimator and image correction technique,' IEEE Trans. Nucl. Sci., vol.52, pp.1396-400, 2005   DOI   ScienceOn
11 T.Y. Song Y. Choi, Y.H. Chung J.J. Jung, Y.S. Choe, K.-H. Lee, et al, 'Optimization of pinhole collimator for small animal SPECT using Mote Carlo simulation,' IEEE Trans. Nuc.l Sci., vol. 50, pp.327-332, 2003   DOI   ScienceOn
12 E.L. Ritman, 'Molecular imaging in small animals-roles for micro-CT,' J. Cell. Biochem. Supp., vol. 39, pp. 116-124, 2002
13 R. Weissleder, and U. Mahmood, 'Molecular imaging,' Radiology, vol. 219, pp. 316-333, 2001   DOI
14 C. Chavarrias, J.J. Vaquero, A. Sisniega, A. Rodriguez-Ruano, M.L. Soto-Montenegro, P. Garcia-Barreno, and M. Desco, 'Extraction of the respiratory signal from small-animal CT projections for a retrospective gating method,' Phys. Med. Biol., vol. 53, pp. 4683-4695, 2008   DOI   ScienceOn
15 D.A. Jaffray, and J.H. Siewerdsen, 'Cone-beam computed tomography with a flat-panel imager: initial performance characterization,' Med. Phys., vol. 27, pp. 1311-1123, 2000   DOI   ScienceOn
16 M.H. Cho, D.H. Lee, B.H. Han, and S.Y. Lee, 'Rotating-gantrybased x-ray micro-tomography system with the sliding mechanism capable of zoom-in imaging,' J. Biomed. Eng. Res., vol. 29, pp. 107-113, 2008
17 M.G. Pomper, 'Molecular imaging: an overview,' Acad. Radiol., vol. 8, pp. 1141-1153, 2001   DOI   ScienceOn
18 S.Y. Wan, A.P. Kiraly, E.L. Ritman, and W.E. Higgins, 'Extraction of the hepatic vasculature in rats using 3-D micro-CT images,' IEEE. Trans. Med. Imag., vol. 19, pp. 964-971, 2000   DOI   ScienceOn
19 C.T. Badea, M. Drangova, D.W. Holdsworth, and G.A. Johnson, 'In vivo small-animal imaging using micro-CT and digital subtraction angiography,' Phys. Med. Biol., vol. 53, pp. R319-R350, 2008   DOI   ScienceOn
20 M.J. Paulus, S.S. Gleason, H. Sari-Sarraf, D.K. Johnson, C.J. Foltz, D.W. Austin, M.E. Easterly, E.J. Michaud, M.S. Dhar, P.R. Hunsicker, J.W. Wall, and M. Schell, 'High-resolution x-ray CT screening of mutant mouse models,' in Proc. SPIE, San Jose, CA, USA, Jan, 2000, vol. 3291, pp. 270-279
21 A.A. Kurth, and R. Muller, 'The effect of an osteolytic tumor on the three-dimensional trabecular bone morphology in an animal model,' Skeletal Radiol., vol. 30, pp. 94-98, 2001   DOI   ScienceOn
22 S.C. Lee, H.K. Kim, I.K. Chun, M.H. Cho, S.Y. Lee, and M.H. Cho, 'A flat-panel detector based micro-CT system: performance evaluation for small-animal imaging,' Phys. Med. Biol., vol. 48, pp. 4173-4185, 2003   DOI   ScienceOn
23 I.K. Chun, M.H. Cho, S.C. Lee, M.H. Cho, and S.Y. Lee, 'X-ray micro-tomography system for small-animal imaging with zoomin imaging capability,' Phys. Med. Biol., vol. 49, pp. 3889-3902, 2004   DOI   ScienceOn
24 S.Y. Wan, E.L. Ritman, and W.E. Higgins, 'Multi-generational analysis and visualization of the vascular tree in 3D micro-CT images,' Comput. Biol. Med., vol. 32, pp. 55-71. 2002   DOI   ScienceOn