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http://dx.doi.org/10.9718/JBER.2008.29.3.173

Polymer Nanofibers for Biomedical Engineering  

Shin, Min-Kyoon (Center for Bio-Artificial Muscle, and Department of Biomedical Engineering, Hanyang University)
Kim, Seon-Jeong (Center for Bio-Artificial Muscle, and Department of Biomedical Engineering, Hanyang University)
Kim, In-Young (Center for Bio-Artificial Muscle, and Department of Biomedical Engineering, Hanyang University)
Kim, Sun-I. (Center for Bio-Artificial Muscle, and Department of Biomedical Engineering, Hanyang University)
Publication Information
Journal of Biomedical Engineering Research / v.29, no.3, 2008 , pp. 173-178 More about this Journal
Abstract
Recent advancements in the electrospinning method enable the production of ultrafine solid and continuous fibers with diameters ranging from a few nanometers to a few hundred nanometers with controlled surface and morphological features. A wide range of biopolymers can be electrospun into mats with a specific fiber arrangement and structural integrity. These features of nanofiber mats are morphologically similar to the extracellular matrix of natural tissues, which are characterized by a wide pore diameter distribution, a high porosity, effective mechanical properties, and specific biochemical properties. This has resulted in various kinds of applications for polymer nanofibers in the field of biomedicine and biotechnology. The current emphasis of research is on exploiting these properties and focusing on determining the appropriate conditions for electrospinning various biopolymers for biomedical applications, including scaffolds used in tissue engineering, wound dressing, drug delivery, artificial organs, and vascular grafts, and for protective shields in specialty fabrics. This paper reviews the research on biomedical applications of electrospun nanofibers.
Keywords
Polymer nanofibers; Electrospinning; Biomedical engineering;
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1 D. Li, Y. Wang, and Y. Xia, 'Electrospinning of polymeric and ceramic nanofibers as uniaxially aligned arrays,' Nano Lett., vol. 3, pp. 1167-1171, 2003   DOI   ScienceOn
2 A. Arinstein, M. Burman, O. Gendelman, and E. Zussman, 'Effect of supramolecular structure on polymer nanofibre elasticity,' Nature Nanotechnology, vol. 2, pp. 59-62, 2007   DOI   ScienceOn
3 M. K. Shin, S. I. Kim, S. J. Kim, S.-K. Kim, H. Lee, and G. M. Spinks, 'Size-dependent elastic modulus of single electroactive polymer nanofibers,' Appl. Phys. Lett., vol. 88, pp. 231929 (3pp.), 2006
4 R. Samatham, I.-S. Park, K. J. Kim, J.-D. Nam, N. Whisman, and J. Adams, 'Electrospun nanoscale polyacrylonitrile artificial muscle,' Smart Mater. Struct., vol. 15, pp. N152-N156, 2006   DOI   ScienceOn
5 D. Fang, X. Xong, W. Chen, S. Cruz, B. Hsiao, and B. Chu, 'Nanostructured electrospun poly-D,L-lactideco-glycolide membranes for anti-adhesion applications,' J. Text. Apparel Technol. Mgmt., vol. 1. Special issue: The Fiber Society Spring 2001 Conference, Raleigh, North Carolina, USA
6 L. Huang, R. A. MacMillian, R. P. Apkarian, B. Pourdeyhimi, V. P. Conticello, and E. L. Chaikof, 'Generation of synthetic elastin mimetic small diameter fibers and fiber networks,' Macromolecules, vol. 33, pp. 2899-2997, 2000
7 D. Li, Y. Wang, and Y. Xia, 'Electrospinning of Polymeric and Ceramic Nanofibers as Uniaxially Aligned Arrays,' Nano Lett., vol. 3, pp. 1167-1171, 2003   DOI   ScienceOn
8 M. K. Shin, S. I. Kim, and S. J. Kim, 'Controlled assembly of polymer nanofibers: From helical springs to fully extended,' Appl. Phys. Lett., vol. 88, pp. 223109 (3pp.), 2006   DOI   ScienceOn
9 E.-R. Kenawy, G. L. Bowlin, and K. Mansfield, 'Release of tetracycline hydrochloride from electrospun poly(ethylene-co -vinylacetate), poly(lactic acid) and a Blend,' J. Controlled Release, vol. 81, pp. 57-64, 2002   DOI   ScienceOn
10 D. H. Reneker, A. L. Yarin, H. Fong, and S. Koombhongse, 'Bending instability of electrically charged liquid jets of polymer solutions in electrospinning,' J. Appl. Phys., vol. 87, pp. 4531-4547, 2000   DOI   ScienceOn
11 A. Vaseashta, 'Controlled formation of multiple Taylor cones in electrospinning process,' Appl. Phys. Lett., vol. 90, pp. 093115 (3pp.), 2007   DOI   ScienceOn
12 E.-R. Kenawy, G. L. Bowlin, K. Mansfield, J. Layman, D. G. Simpson, E. H. Sanders, and G. E. Wnek, 'Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend,' J. Controlled Release, vol. 81, pp. 57-64, 2002   DOI   ScienceOn
13 E. P. S. Tan, S. Y. Ng, and C. T. Lim, 'Tensile testing of a single ultrafine polymeric fiber,' Biomaterials, vol. 26, pp. 1453-1456, 2005   DOI   ScienceOn
14 L. Huang, K. Nagapundi, and E. L. Chaikof, 'Engineered collagen PEO nanofibers and fabrics. J. Biomater,' Sci. Polym. Ed., vol. 12, pp. 979-993, 2001
15 B. D. Ratner, 'New ideas in biomaterials science a path to engineered biomaterials,' J. Biomed. Mater. Res., vol. 27, pp. 837-850, 1993   DOI   ScienceOn
16 W. J. Li, C. T. Laurencin, E. J. Caterson, R. S. Tuan, and F. K. Ko, 'Electrospun nanofibrous structure: a novel scaffold for tissue engineering,' J. Biomed. Mater. Res., vol. 60, pp. 613-621, 2002   DOI   ScienceOn
17 X. M. Mo, C. Y. Xu, M. Kotaki, and S. Ramakrishna, 'Electrospun P(LLA-CL) nanofiber: a biomimitic extracellular matrix for smooth muscle cell and endothelial cell proliferation,' Biomaterials, vol. 25, pp. 1883-1890, 2004   DOI   ScienceOn
18 B. K. Gu, M. K. Shin, K. W. Sohn, S. I. Kim, S. J. Kim, S.-K. Kim, H. Lee, and J. S. Park, 'Direct fabrication of twisted nanofibers by electrospinning,' Appl. Phys. Lett., vol. 90, pp. 263902 (3 pp.), 2007   DOI   ScienceOn
19 G. L. Bowlin, J. A. Matthews, D. G. Simpson, E. R. Kenawy, and G. E. Wnek, 'Electrospinning biomaterials,' J. Text. Apparel Technol. Mgmt., vol. 1. Special issue: The Fiber Society Spring 2001 Conference, Raleigh, North Carolina, USA
20 J. Venugopal, Y. Z. Zhang, and S. Ramakrishna, 'Electrospun nanofibers: biomedical applications,' Proc. IMechE Part N: J. Nanoengineering and Nanosystems, vol. 218, pp. 35-45, 2005
21 C. J. Buchko, L. C. Chen, Y. Shen, and D. C. Martin, 'Processing and microstructural characterization of porous biocompatible protein thin films,' Polymer., vol. 40, pp. 7397-7407, 1999   DOI   ScienceOn
22 D. Adam, 'A fine set of threads,' Nature, vol. 411, pp. 236, 2001   DOI   PUBMED   ScienceOn
23 K. Kim, M. Yu, X. Zong, J. Chiu, D. Fang, B. S. Hsiao, B. Chu, and M. Hadjiargyrou, 'Control of degradation rate and hydrophilicity in electrospun non-woven poly(D,L-lactide) nanofiber scaffolds for biomedical applications,' Biomaterials, vol. 24, pp. 4977-4985, 2003   DOI   ScienceOn
24 T. Nakamura, S. Hitomi, S. Watanabe, Y. Shimizu, K. Jamshidi, S. H. Hyon, and Y. Ikada, 'Bioabsorption of polylactides with different molecular properties,' J. Biomed. Mater. Res., vol. 23, pp. 1115-1130, 1989   DOI   ScienceOn
25 J. Zeng, X. Xu, X. Chen, Q. Liang, X. Bian, L.Yang, and X. Jing, 'Biodegradable electrospun fibers for drug delivery,' J. Controlled Release, vol. 92, pp. 227 -231, 2003   DOI   ScienceOn
26 J. Zeng, A. Aigner, F. Czubayko, T. Kissel, J. H. Wendorff, and A. Greiner, 'Poly(vinyl alcohol) nanofibers by electrospinning as a protein delivery system and the retardation of enzyme release by additional polymer coatings,' Biomacromolecules, vol. 6, pp. 1484-1488, 2005   DOI   ScienceOn
27 J. M. Deitzel, J. Kleinmeyer, D. Harris, and N. C. Beck Tan, 'The effect of processing variables on the morphology of electrospun nanofibers and textiles,' Polymer, vol. 42, pp. 261-272, 2001   DOI   ScienceOn
28 Y. Dzenis, 'Spinning continuous fibers for nanotechnology,' Science, vol. 304, pp. 1917-1919, 2004   DOI   ScienceOn
29 www.electrosols.com
30 R. Samatham, I.-S. Park, K. J. Kim, J.-D. Nam, N. Whisman, and J. Adams, 'Electrospun nanoscale polyacrylonitrile artificial muscle,' Smart Mater. Struct., vol. 15, N152-N156, 2006   DOI   ScienceOn
31 D. Li and Y. Xia, 'Electrospinning of Nanofibers: Reinventing the Wheel?,' Adv. Mater., vol. 16 , pp. 1151-1170, 2004   DOI   ScienceOn
32 C. Y. Xu, R. Inai, M. Kotaki, and S. Ramakrishna, 'Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering,' Biomaterials, vol. 25, pp. 877-886, 2004   DOI   ScienceOn
33 H. Schreuder-Gibson, International Conference on textile coating and laminating: preparing for the future a new millennium, 8th, Frankfurt, Germany, 1998, Paper No 17/ 11-Paper No 17/24
34 J. A. Matthews, G. E. Wnek, D. G. Simpson, and G. L. Bowlin, 'Electrospinning of collagen nanofibers,' Biomacromolecules, vol. 3, pp. 232-238, 2002   DOI   ScienceOn
35 W. Kataphinan, S. Dabney, D. Smith, and D. H. Reneker, 'Fabrication of electrospun and encapsulation into polymer nanofibers,' J. Text. Apparel Technol. Mgmt., vol. 1. Special issue: The Fiber Society Spring 2001 Conference, Raleigh, North Carolina, USA
36 S. E. Ross, 'Electrospinning: the quest for nanofibers,' Int. Fibre J., vol. 16, pp. 50-53, 2001
37 R. S. Dubrow, L. A. Bock, R. H. Daniels, V. D. Hardev, C. Niu, V. Sahi, US Patent No. 2006204738, 2006
38 M. K. Shin, S. I. Kim, and S. J. Kim, 'Alignment of polymeric nanofibers using a filtering effect,' J. Nanosci. Nanotechnol., In press, 2008
39 D. J. Smith, D. H. Reneker, A. T. McManus, H. L. Schreuder-Gibson, C. Mello, and M. S. Sennett, 'Electrospun fibers and an apparatus therefore,' US Patent No. 6753454, 2004
40 H. J. Jin, S. Fridrikh, G. C. Rutledge, and D. Kaplan, 'Electrospinning bombyx mori silk with poly(ethylene oxide),' Abstracts of Papers American Chemical Society, vol. 224, pp. 408, 2002
41 M. J. Miller, and G. R. D. Evans, 'Tissue engineering and plastic surgery,' In Frontiers in Tissue Engineering (Eds C. W. Patrick, A. G. Mikos, and L. V. McIntire), pp. 213-232 (Pergamon, New York, USA), 1998
42 D. H. Reneker and I. Chun, 'Nanometre diameter fibres of polymer, produced by electrospinning,' Nanotechnology, vol. 7, pp. 216-223, 1996   DOI   ScienceOn