Sp1-Induced SETDB1 Overexpression Transcriptionally Inhibits HPGD in a β-Catenin-Dependent Manner and Promotes the Proliferation and Metastasis of Gastric Cancer |
Fan, Yaguan
(Department of Medical Oncology, The First People's Hospital of Yunnan Province)
Yang, Libo (Department of Medical Oncology, The First People's Hospital of Yunnan Province) Ren, Yi (Department of Medical Oncology, The First People's Hospital of Yunnan Province) Wu, Yunhua (Department of Medical Oncology, The First People's Hospital of Yunnan Province) Li, Linhai (Department of General Surgery, The First People's Hospital of Yunnan Province) Li, Lihua (Department of Medical Oncology, The First People's Hospital of Yunnan Province) |
1 | Zhang Y, Wang X. Targeting the Wnt/β-catenin signaling pathway in cancer. J Hematol Oncol 2020;13:165. DOI |
2 | Li Y, Jin K, van Pelt GW, van Dam H, Yu X, Mesker WE, et al. c-Myb enhances breast cancer invasion and metastasis through the Wnt/β-catenin/Axin2 pathway. Cancer Res 2016;76:3364-3375. |
3 | Tian S, Peng P, Li J, Deng H, Zhan N, Zeng Z, et al. SERPINH1 regulates EMT and gastric cancer metastasis via the Wnt/β-catenin signaling pathway. Aging (Albany NY) 2020;12:3574-3593. |
4 | Zhong B, Wang Q, He J, Xiong Y, Cao J. LncRNA LOC285194 modulates gastric carcinoma progression through activating Wnt/β-catenin signaling pathway. Cancer Med 2020;9:2181-2189. DOI |
5 | Yao S, Xu J, Zhao K, Song P, Yan Q, Fan W, et al. Down-regulation of HPGD by miR-146b-3p promotes cervical cancer cell proliferation, migration and anchorage-independent growth through activation of STAT3 and AKT pathways. Cell Death Dis 2018;9:1055. DOI |
6 | Xu J, Wan X, Chen X, Fang Y, Cheng X, Xie X, et al. miR-2861 acts as a tumor suppressor via targeting EGFR/AKT2/CCND1 pathway in cervical cancer induced by human papillomavirus virus 16 E6. Sci Rep 2016;6:28968. DOI |
7 | Rifai K, Judes G, Idrissou M, Daures M, Bignon YJ, Penault-Llorca F, et al. SIRT1-dependent epigenetic regulation of H3 and H4 histone acetylation in human breast cancer. Oncotarget 2018;9:30661-30678. DOI |
8 | Huang C, Xie K. Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis. Cytokine Growth Factor Rev 2012;23:25-35. DOI |
9 | Wang L, Wei D, Huang S, Peng Z, Le X, Wu TT, et al. Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer. Clin Cancer Res 2003;9:6371-6380. |
10 | Guo MM, Hu LH, Wang YQ, Chen P, Huang JG, Lu N, et al. miR-22 is down-regulated in gastric cancer, and its overexpression inhibits cell migration and invasion via targeting transcription factor Sp1. Med Oncol 2013;30:542. DOI |
11 | Cao N, Yu Y, Zhu H, Chen M, Chen P, Zhuo M, et al. SETDB1 promotes the progression of colorectal cancer via epigenetically silencing p21 expression. Cell Death Dis 2020;11:351. DOI |
12 | Lazaro-Camp VJ, Salari K, Meng X, Yang S. SETDB1 in cancer: overexpression and its therapeutic implications. Am J Cancer Res 2021;11:1803-1827. |
13 | Na HH, Moon S, Kim KC. Knockout of SETDB1 gene using the CRISPR/cas-9 system increases migration and transforming activities via complex regulations of E-cadherin, β-catenin, STAT3, and Akt. Biochem Biophys Res Commun 2020;533:486-492. DOI |
14 | Song L, Guo X, Zhao F, Wang W, Zhao Z, Jin L, et al. TTC36 inactivation induce malignant properties via Wnt-β-catenin pathway in gastric carcinoma. J Cancer 2021;12:2598-2609. DOI |
15 | Schinzari G, Cassano A, Orlandi A, Basso M, Barone C. Targeted therapy in advanced gastric carcinoma: the future is beginning. Curr Med Chem 2014;21:1026-1038. DOI |
16 | Monteleone NJ, Moore AE, Iacona JR, Lutz CS, Dixon DA. miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer. Sci Rep 2019;9:5405. DOI |
17 | Park JM, Na HK. 15-Deoxy-Δ12,14-prostaglandin J2 upregulates the expression of 15-hydroxyprostaglandin dehydrogenase by inducing AP-1 activation and heme oxygenase-1 expression in human colon cancer cells. J Cancer Prev 2019;24:183-191. DOI |
18 | Thiel A, Ganesan A, Mrena J, Junnila S, Nykanen A, Hemmes A, et al. 15-Hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer. Clin Cancer Res 2009;15:4572-4580. DOI |
19 | Mir R, Sharma A, Pradhan SJ, Galande S. Regulation of transcription factor Sp1 by the β-catenin destruction complex modulates Wnt response. Mol Cell Biol 2018;38:e00188-18. |
20 | Wolf I, O'Kelly J, Rubinek T, Tong M, Nguyen A, Lin BT, et al. 15-Hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer. Cancer Res 2006;66:7818-7823. DOI |
21 | Lou LH, Jing DD, Lai YX, Lu YY, Li JK, Wu K. 15-PGDH is reduced and induces apoptosis and cell cycle arrest in gastric carcinoma. World J Gastroenterol 2012;18:1028-1037. DOI |
22 | Song HJ, Myung SJ, Kim IW, Jeong JY, Park YS, Lee SM, et al. 15-Hydroxyprostaglandin dehydrogenase is downregulated and exhibits tumor suppressor activity in gastric cancer. Cancer Invest 2011;29:257-265. DOI |
23 | Matsuo M, Ensor CM, Tai HH. Characterization of the genomic structure and promoter of the mouse NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene. Biochem Biophys Res Commun 1997;235:582-586. DOI |
24 | Vizcaino C, Mansilla S, Portugal J. Sp1 transcription factor: a long-standing target in cancer chemotherapy. Pharmacol Ther 2015;152:111-124. DOI |
25 | Wang S, Li Y, Sun S, Cai J, Cao J. Sp1 promotes ovarian cancer cell migration through repressing miR-335 expression. Biochem Biophys Res Commun 2020;524:211-216. DOI |
26 | Deng YR, Chen XJ, Chen W, Wu LF, Jiang HP, Lin D, et al. Sp1 contributes to radioresistance of cervical cancer through targeting G2/M cell cycle checkpoint CDK1. Cancer Manag Res 2019;11:5835-5844. DOI |
27 | Hu L, Chen Q, Wang Y, Zhang N, Meng P, Liu T, et al. Sp1 mediates the constitutive expression and repression of the PDSS2 gene in lung cancer cells. Genes (Basel) 2019;10:977. DOI |
28 | Shang W, Wang Y, Liang X, Li T, Shao W, Liu F, et al. SETDB1 promotes gastric carcinogenesis and metastasis via upregulation of CCND1 and MMP9 expression. J Pathol 2021;253:148-159. DOI |
29 | Nusse R, Clevers H. Wnt/β-catenin signaling, disease, and emerging therapeutic modalities. Cell 2017;169:985-999. DOI |
30 | Wang Z, Li B, Zhou L, Yu S, Su Z, Song J, et al. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A 2016;113:13150-13155. DOI |
31 | Lou Z, O'Reilly S, Liang H, Maher VM, Sleight SD, McCormick JJ. Down-regulation of overexpressed Sp1 protein in human fibrosarcoma cell lines inhibits tumor formation. Cancer Res 2005;65:1007-1017. DOI |
32 | Wang G, Long J, Gao Y, Zhang W, Han F, Xu C, et al. SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. Nat Cell Biol 2019;21:214-225. DOI |
33 | Karanth AV, Maniswami RR, Prashanth S, Govindaraj H, Padmavathy R, Jegatheesan SK, et al. Emerging role of SETDB1 as a therapeutic target. Expert Opin Ther Targets 2017;21:319-331. DOI |
34 | Qi X, Wang Y, Hou J, Huang Y. A single nucleotide polymorphism in HPGD gene is associated with prostate cancer risk. J Cancer 2017;8:4083-4086. DOI |
35 | Fink SP, Yamauchi M, Nishihara R, Jung S, Kuchiba A, Wu K, et al. Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD). Sci Transl Med 2014;6:233re2. |
36 | Ogino S, Jhun I, Mata DA, Soong TR, Hamada T, Liu L, et al. Integration of pharmacology, molecular pathology, and population data science to support precision gastrointestinal oncology. NPJ Precis Oncol 2017;1:40. DOI |
37 | Idrissou M, Boisnier T, Sanchez A, Khoufaf FZ, Penault-Llorca F, Bignon YJ, et al. TIP60/P400/H4K12ac plays a role as a heterochromatin back-up skeleton in breast cancer. Cancer Genomics Proteomics 2020;17:687-694. DOI |
38 | Shi Q, Le X, Abbruzzese JL, Peng Z, Qian CN, Tang H, et al. Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. Cancer Res 2001;61:4143-4154. |
39 | Yang XZ, Cheng TT, He QJ, Lei ZY, Chi J, Tang Z, et al. LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway. Mol Cancer 2018;17:126. DOI |
40 | Wu R, Liu T, Yang P, Liu X, Liu F, Wang Y, et al. Association of 15-hydroxyprostaglandin dehydrogenate and poor prognosis of obese breast cancer patients. Oncotarget 2017;8:22842-22853. DOI |
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