Successful Treatment of Advanced Gastric Cancer with Brain Metastases through an Abscopal Effect by Radiation and Immune Checkpoint Inhibitor Therapy |
Muto, Momotaro
(Department of Internal Medicine, Engaru Kosei General Hospital)
Nakata, Hirotaka (Department of Internal Medicine, Engaru Kosei General Hospital) Ishigaki, Kenichi (Department of Internal Medicine, Engaru Kosei General Hospital) Tachibana, Shion (Department of Internal Medicine, Engaru Kosei General Hospital) Yoshida, Moe (Department of Internal Medicine, Engaru Kosei General Hospital) Muto, Mizue (Department of Internal Medicine, Engaru Kosei General Hospital) Yanagawa, Nobuyuki (Department of Internal Medicine, Engaru Kosei General Hospital) Okumura, Toshikatsu (Division of Metabolism, Systemic Bioscience, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University) |
1 | D'Souza NM, Fang P, Logan J, Yang J, Jiang W, Li J. Combining radiation therapy with immune checkpoint blockade for central nervous system malignancies. Front Oncol 2016;6:212. DOI |
2 | Postow MA, Callahan MK, Barker CA, Yamada Y, Yuan J, Kitano S, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med 2012;366:925-931. DOI |
3 | Choi CW, Jeong MH, Park YS, Son CH, Lee HR, Koh EK. Combination treatment of stereotactic body radiation therapy and immature dendritic cell vaccination for augmentation of local and systemic effects. Cancer Res Treat 2019;51:464-473. DOI |
4 | Stamell EF, Wolchok JD, Gnjatic S, Lee NY, Brownell I. The abscopal effect associated with a systemic anti-melanoma immune response. Int J Radiat Oncol Biol Phys 2013;85:293-295. DOI |
5 | Kasakura Y, Fujii M, Mochizuki F, Suzuki T, Takahashi T. Clinicopathological study of brain metastasis in gastric cancer patients. Surg Today 2000;30:485-490. DOI |
6 | Levy A, Massard C, Soria JC, Deutsch E. Concurrent irradiation with the anti-programmed cell death ligand-1 immune checkpoint blocker durvalumab: single centre subset analysis from a phase 1/2 trial. Eur J Cancer 2016;68:156-162. DOI |
7 | Hiniker SM, Chen DS, Reddy S, Chang DT, Jones JC, Mollick JA, et al. A systemic complete response of metastatic melanoma to local radiation and immunotherapy. Transl Oncol 2012;5:404-407. DOI |
8 | Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy. Science 2015;348:69-74. DOI |
9 | Han JH, Kim DG, Chung HT, Kim CY, Park CK, Chung YS, et al. Radiosurgery for brain metastasis from advanced gastric cancer. Acta Neurochir (Wien) 2010;152:605-10. DOI |
10 | Grimaldi AM, Simeone E, Giannarelli D, Muto P, Falivene S, Borzillo V, et al. Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy. OncoImmunology 2014;3:e28780. DOI |
11 | Brenneman RJ, Sharifai N, Fischer-Valuck B, Hassanzadeh C, Guzelian J, Chrisinger JS, et al. Abscopal effect following proton beam radiotherapy in a patient with inoperable metastatic retroperitoneal sarcoma. Front Oncol 2019;9:922. DOI |
12 | Choi JS, Sansoni ER, Lovin BD, Lindquist NR, Phan J, Mayo LL, et al. Abscopal effect following immunotherapy and combined stereotactic body radiation therapy in recurrent metastatic head and neck squamous cell carcinoma: a report of two cases and literature review. Ann Otol Rhinol Laryngol 2019;129:517-522. |
13 | Garelli E, Rittmeyer A, Putora PM, Glatzer M, Dressel R, Andreas S. Abscopal effect in lung cancer: three case reports and a concise review. Immunotherapy 2019;11:1445-1461. DOI |
14 | Galon J, Bruni D. Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. Nat Rev Drug Discov 2019;18:197-218. DOI |
15 | McDermott MW, Sneed PK. Radiosurgery in metastatic brain cancer. Neurosurgery 2005;57:S45-S53. |
16 | York JE, Stringer J, Ajani JA, Wildrick DM, Gokaslan ZL. Gastric cancer and metastasis to the brain. Ann Surg Oncol 1999;6:771-776. DOI |
17 | Kraszkiewicz M, Wydmanski J. Brain metastases from stomach cancer - The role of different treatment modalities and efficacy of palliative radiotherapy. Rep Pract Oncol Radiother 2014;20:32-37. DOI |
![]() |