Browse > Article
http://dx.doi.org/10.5230/jgc.2014.14.1.54

Gastric Carcinoma with Bone Marrow Metastasis: A Case Series  

Ekinci, Ahmet Siyar (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital)
Bal, Oznur (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital)
Ozatli, Tahsin (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital)
Turker, Ibrahim (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital)
Esbah, Onur (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital)
Demirci, Ayse (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital)
Budakoglu, Burcin (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital)
Arslan, Ulku Yalcintas (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital)
Eraslan, Emrah (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital)
Oksuzoglu, Berna (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital)
Publication Information
Journal of Gastric Cancer / v.14, no.1, 2014 , pp. 54-57 More about this Journal
Abstract
Gastric cancer is a major cause of cancer-related mortality. At the time of diagnosis, majority of the patients usually have unresectable or metastatic disease. The most common sites of metastases are the liver and the peritoneum, but in the advanced stages, there may be metastases to any region of the body. Bone marrow is an important metastatic site for solid tumors, and the prognosis in such cases is poor. In gastric cancer cases, bone marrow metastasis is usually observed in younger patients and in those with poorly differentiated tumors. Prognosis is worsened owing to the poor histomorphology as well as the occurrence of pancytopenia. The effect of standard chemotherapy is unknown, as survival is limited to a few weeks. This report aimed to evaluate 5 gastric cancer patients with bone marrow metastases to emphasize the importance of this condition.
Keywords
Stomach neoplasms; Bone marrow metastasis; Poor prognosis;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Kwon JY, Yun J, Kim HJ, Kim KH, Kim SH, Lee SC, et al. Clinical outcome of gastric cancer patients with bone marrow metastases. Cancer Res Treat 2011;43:244-249.   DOI   ScienceOn
2 Finklestein JZ, Ekert H, Isaacs H Jr, Higgins G. Bone marrow metastases in children with solid tumors. Am J Dis Child 1970;119:49-52.
3 Kim HS, Yi SY, Jun HJ, Lee J, Park JO, Park YS, et al. Clinical outcome of gastric cancer patients with bone marrow metastases. Oncology 2007;73:192-197.   DOI   ScienceOn
4 Kusumoto H, Haraguchi M, Nozuka Y, Oda Y, Tsuneyoshi M, Iguchi H. Characteristic features of disseminated carcinomatosis of the bone marrow due to gastric cancer: the pathogenesis of bone destruction. Oncol Rep 2006;16:735-740.
5 Ahn JB, Ha TK, Kwon SJ. Bone metastasis in gastric cancer patients. J Gastric Cancer 2011;11:38-45.   DOI   ScienceOn
6 Nishidoi H, Koga S. Clinicopathological study of gastric cancer with bone metastasis. Gan To Kagaku Ryoho 1987;14:1717-1722.
7 Ajani JA, Moiseyenko VM, Tjulandin S, Majlis A, Constenla M, Boni C, et al; V-325 Study Group. Clinical benefit with docetaxel plus fluorouracil and cisplatin compared with cisplatin and fluorouracil in a phase III trial of advanced gastric or gastroesophageal cancer adenocarcinoma: the V-325 Study Group. J Clin Oncol 2007;25:3205-3209.   DOI
8 Ministry of Health, Public Health Agency Turkey. T.C. Saglik Bakanligi Türkiye Halk Sagligi Kurumu [Internet]. Ankara: Ministry of Health, Public Health Agency Turkey; 2008. Available from: http://www.kanser.gov.tr.
9 Anner RM, Drewinko B. Frequency and significance of bone marrow involvement by metastatic solid tumors. Cancer 1977;39:1337-1344.   DOI   ScienceOn
10 Kilickap S, Erman M, Dincer M, Aksoy S, Harputluoglu H, Yalcin S. Bone marrow metastasis of solid tumors: clinicopathological evaluation of 73 cases. Turk J Cancer 2007;37:85-88.
11 Mehdi SR, Bhatt ML. Metastasis of solid tumors in bone marrow: a study from northern India. Indian J Hematol Blood Transfus 2011;27:2:93-95.
12 Mohanty SK, Dash S. Bone marrow metastasis in solid tumors. Indian J Pathol Microbiol 2003;46:613-616.
13 Tasleem RA, Chowdhary ND, Kadri SM, Chowdhary QA. Metastasis of solid tumours in bone marrow: a study from Kashmir, India. J Clin Pathol 2003;56:803.   DOI
14 Clifton JA, Philipp RJ, Ludovic E, Fowler WM. Bone marrow and carcinoma of the prostate. Am J Med Sci 1952;224:121-130.   DOI
15 Frisch B, Bartl R, Burkhardt R. Bone marrow biopsy in clinical medicine: an overview. Haematologia (Budap) 1982;15:245-285.
16 Penchansky L. Bone marrow biopsy in the metastatic work-up of solid tumors in children. Cancer 1984;54:1447-1448.   DOI
17 Wong KF, Chan JK, Ma SK. Solid tumour with initial presentation in the bone marrow--a clinicopathologic study of 25 adult cases. Hematol Oncol 1993;11:35-42.   DOI   ScienceOn
18 Kong JH, Lee J, Yi CA, Park SH, Park JO, Park YS, et al. Lung metastases in metastatic gastric cancer: pattern of lung metastases and clinical outcome. Gastric Cancer 2012;15:292-298.   DOI