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Lim, H., Park, H. and Kim, H. P. (2011b) Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms: Inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways. J. Pharmacol. Sci. 116, 221-231.
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Park, B. K., Heo, M. Y., Park. H. and Kim, H. P. (2001) Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix. Eur. J. Pharmacol. 425, 153-157.
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3 |
You, K. M., Jong, H.-G. and Kim, H. P. (1999) Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants. Arch. Pharm. Res. 22, 18-24.
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Kim, H. K., Cheon, B. S., Kim, Y. H., Kim, S. Y. and Kim, H. P. (1999a) Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem. Pharmacol. 58, 759-765.
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Lim, H. and Kim, H. P. (2011) Matrix metalloproteinase-13 expression in IL-1β-treated chondrocytes by activation of the p38 MAPK/c-Fos/AP-1 and JAK/STAT pathways. Arch. Pharm. Res. 34, 109-117.
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Ko, H. J., Kwon, O. S., Jin, J. H., Son, K. H. and Kim, H. P. (2013) Inhibition of experimental systemic inflammation (septic inflammation) and chronic bronchitis by new phytoformula BL containing Broussonetia papyrifera and Lonicera japonica. Biomol. Ther. (Seoul) 21, 66-71.
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7 |
Lee, S. J., Baek, H. J., Lee, C. H. and Kim, H. P. (1994) Antiinflammatory activity of isoflavonoids from Pueraria radix and biochanin A derivatives. Arch. Pharm. Res. 17, 31-35.
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Lim, H. and Kim, H. P. (2007) Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally-occurring flavonoids. Planta Med. 73, 1267-1274.
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Lim, H., Kwon, Y. S., Kim, D., Lee, J. and Kim, H. P. (2020) Flavonoids from Scutellaria baicalensis inhibit senescence-associated secretory phenotype production by interrupting IκBζ/C/EBPβ pathway: Inhibition of age-related inflammation. Phytomedicine 76, 153255.
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Lim, H., Min, D. S., Park, H. and Kim, H. P. (2018) Flavonoids interfere with NLRP3 inflammasome activation. Toxicol. Appl. Pharmacol. 355, 93-102.
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11 |
Lim, H., Park, H. and Kim, H. P. (2004) Inhibition of contact dermatitis in animal models and suppression of proinflammatory gene expression by topically applied flavonoid, wogonin. Arch. Pharm. Res. 27, 442-448.
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12 |
Chi, Y. S., Jong, H. G., Son, K. H., Chang, H. W., Kang, S. S. and Kim, H. P. (2001b) Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases. Biochem. Pharmacol. 62, 1185-1191.
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13 |
Lim, H., Park, H. and Kim, H. P. (2015) Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycininduced senescence in BJ fibroblasts. Biochem. Pharmacol. 96, 337-348.
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Lim, H., Son, K. H., Chang, H. W., Kang, S. S. and Kim, H. P. (2006a) Effects of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammation. Biol. Pharm. Bull. 29, 1046-1049.
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15 |
Chi, Y. S., Lim, H., Park, H. and Kim, H. P. (2003) Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Biochem. Pharmacol. 66, 1271-1278.
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16 |
Dao, T. T., Chi, Y. S., Kim, J., Kim, H. P., Kim, S. and Park, H. (2003a) Synthesis and PGE2 inhibitory activity of 5,7-dihydroxyflavones and their O-methylated flavone analogs. Arch. Pharm. Res. 26, 345-350.
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17 |
Kim, Y. H., Kim, J., Park, H. and Kim, H. P. (2007) Anti-inflammatory activity of the synthetic chalcone derivatives: inhibition of inducible nitric oxide synthase-catalyzed nitric oxide production from lipopolysaccharide-treated RAW 264.7 cells. Biol. Pharm. Bull. 30, 1450-1455.
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18 |
Dao, T. T., Oh, J. W., Chi, Y. S., Kim, H. P., Sin, K.-S. and Park, H. (2003b) Synthesis and PGE2 inhibitory activity of vinylated and allylated chrysin analogues. Arch. Pharm. Res. 26, 581-584.
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Kim, H. P., Son, K. H., Chang, H. W. and Kang, S. S. (2000) Effects of naturally occurring flavonoids on inflammatory responses and their action mechanisms. Nat. Prod. Sci. 6, 170-178.
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Kwak, W. J., Han, C. K., Son, K. H., Chang, H. W., Kang, S. S., Park, B. K. and Kim, H. P. (2002) Effects of ginkgetin from Ginkgo biloba leaves on cyclooxygenases and in vivo skin inflammation. Planta Med. 68, 316-321.
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21 |
Lee, S. J., Son, K. H., Chang, H. W., Do, J. C., Jung, K. Y., Kang, S. S. and Kim, H. P. (1993) Antiinflammatory activity of naturally occurring flavone and flavonol glycosides. Arch. Pharm. Res. 16, 25-28.
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Kim, H. P. (2005) Histopathological comparison of animal models of skin inflammation and inhibition of the inflammatory responses by plant flavonoid, wogonin. J. Appl. Pharmacol. 13, 133-137.
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Jin, J. H., Kim, J. S., Kang, S. S., Son, K. H., Chang, H. W. and Kim, H. P. (2010b) Anti-inflammatory and anti-arthritic activity of total flavonoids of the roots of Sophora flavescens. J. Ethnopharmacol. 127, 589-595.
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Kim, B. J., Kim, J. H., Heo, M. Y. and Kim, H. P. (1998a) Anti-oxidative and anti-inflammatory activities of the mung bean. Cosmetics and Toiletries 113, 71-74.
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Kim, H. K., Namgoong, S. Y. and Kim, H. P. (1993) Antiinflammatory activity of flavonoids: mouse ear edema inhibition. Arch. Pharm. Res. 16, 18-24.
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Kim, H. P. (2007) Molecular events on experimental skin inflammation and modulation by topical anti-inflammatory flavonoids. J. Appl. Pharmacol. 15, 7-15.
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Kim, H. P., Park, H., Son, K. H., Chang, H. W. and Kang, S. S. (2008) Biochemical pharmacology of biflavonoids: implications for antiinflammatory action. Arch. Pharm. Res. 31, 265-273.
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Lim, H., Son, K. H., Chang, H. W., Kang, S. S. and Kim, H. P. (2006b) Inhibition of chronic skin inflammation by topical anti-inflammatory flavonoid preparation, Ato Formula®. Arch. Pharm. Res. 29, 503-507.
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Lim, H. J., Jin, H. G., Woo, E. R., Lee, S. K. and Kim, H. P. (2013) The root barks of Morus alba and the flavonoid constituents inhibit airway inflammation. J. Ethnopharmacol. 149, 169-175.
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Bondonno, N. P., Dalgaard, F., Kyro, C., Murray, K., Bondonno, C. P., Lewis, J. R., Croft, K. D., Gislason, G., Scalbert, A., Cassidy, A., Tjonneland, A., Overvad, K. and Hodgson, J. M. (2019) Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort. Nat. Commun. 10, 3651.
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Park, H., Dao, T. T. and Kim, H. P. (2005) Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives. Eur. J. Med. Chem. 40, 943-948.
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Kim, D. W., Chi, Y. S., Son, K. H., Chang, H. W., Kim, J. S., Kang, S. S. and Kim, H. P. (2002) Effects of sophoraflavanone G, a prenylated flavonoid from Sophora flavescens, on cyclooxygenase-2 and in vivo inflammatory response. Arch. Pharm. Res. 25, 329-335.
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33 |
Chi, Y. S. and Kim, H. P. (2005) Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. Prostaglandins Leukot. Essent. Fatty Acids 72, 59-66.
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Gurung, S. K., Kim, H. P. and Park, H. (2009) Inhibition of prostaglandin E2 production by synthetic wogonin analogs. Arch. Pharm. Res. 32, 1503-1508.
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Kim, H. P., Son, K. H., Chang, H. W. and Kang, S. S. (2004) Antiinflammatory plant flavonoids and cellular action mechanisms. J. Pharmacol. Sci. 96, 229-245.
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Lim, H., Jin, J. H., Park, H. and Kim, H. P. (2011a) New synthetic anti-inflammatory chrysin analog, 5,7-dihydroxy-8-(pyridine-4yl) flavone. Eur. J. Pharmacol. 670, 617-622.
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37 |
Lim, H., Kim, S. B., Park, H., Chang, H. W. and Kim, H. P. (2009) New anti-inflammatory synthetic biflavonoid with C-C (6-6") linkage: differential effects on cyclooxygenase-2 and inducible nitric oxide synthase. Arch. Pharm. Res. 32, 1525-1531.
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Dao, T. T., Kim, S. B., Sin, K.-S., Kim, S., Kim, H. P. and Park, H. (2004b) Synthesis and biological activities of 8-arylflavones. Arch. Pharm. Res. 27, 278-282.
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Han, C. K., Son, M. J., Chang, H. W., Chi, Y. S., Park, H. and Kim, H. P. (2005) Inhibition of prostaglandin production by a structurally-optimized flavonoid derivative, 2',4',7-trimethoxyflavone and cellular action mechanism. Biol. Pharm. Bull. 28, 1366-1370.
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Jin, J. H., Lim, H., Kwon, S. Y., Son, K. H. and Kim, H. P. (2010a) Anti-inflammatory activity of the total flavonoid fraction from Broussonetia papyrifera in combination with Lonicera japonica. Biomol. Ther. (Seoul) 18, 197-204.
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Park, H., Kim, Y. H., Chang, H. W. and Kim, H. P. (2006a) Anti-inflammatory activity of the synthetic C-C biflavonoids. J. Pharm. Pharmacol. 58, 1661-1667.
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Park, H., Sin, B. Y. and Kim, H. P. (2006b) Inhibition of collagenase by anti-inflammatory synthetic flavones. J. Appl. Pharmacol. 14, 36-39.
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Sin, B. Y. and Kim, H. P. (2005) Inhibition of collagenase by naturally-occurring flavonoids. Arch. Pharm. Res. 28, 1152-1155.
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Choi, H. R., Lim, H., Lee, J. H., Park, H. and Kim, H. P. (2021) Interruption of Helicobacter pylori-induced NLRP3 inflammasome activation by chalcone derivatives. Biomol. Ther. (Seoul) 29, 410-418.
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Che, H., Park, B. K., Lim, H., Kim, H. P., Chang, H. W., Jeong, J.-H. and Park, H. (2009) Synthesis of biflavones having a 6-O-7'' linkage and effects on cyclooxygenase-2 and inducible nitric oxide synthase. Bioorg. Med. Chem. Lett. 19, 74-76.
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Cheon, B. S., Kim, Y. H., Son, K. H., Chang, H. W., Kang, S. S. and Kim, H. P. (2000) Effects of prenylated flavonoids and biflavonoids on lipopolysaccharide-induced nitric oxide production from the mouse macrophage cell line RAW 264.7. Planta Med. 66, 596-600.
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47 |
Chi, Y. S., Cheon, B. S. and Kim, H. P. (2001a) Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. Biochem. Pharmacol. 61, 1195-1203.
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48 |
Dao, T. T., Chi, Y. S., Kim, J., Kim, H. P., Kim, S. and Park, H. (2004a) Synthesis and inhibitory activity against COX-2 catalyzed prostaglandin production of chrysin derivatives. Bioorg. Med. Chem. Lett. 14, 1165-1167.
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49 |
Jang, J., Kim, H. P. and Park, H. (2005) Structure and antiinflammatory activity relationships of wogonin derivatives. Arch. Pharm. Res. 28, 877-884.
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Kim, H. K., Son, K. H., Chang, H. W., Kang, S. S. and Kim, H. P. (1999b) Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from Ginkgo biloba leaves. Planta Med. 65, 465-467.
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51 |
Kim, H. P., Son, K. H., Chang, H. W. and Kang, S. S. (1996) Flavonoids: potential antiinflammatory agents. Nat. Prod. Sci. 2, 1-8.
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Kim, H. P., Mani, I., Iversen, L. and Ziboh, V. A. (1998b) Effects of naturally-occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea-pigs. Prostaglandins Leukot. Essent. Fatty Acids 58, 17-24.
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