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http://dx.doi.org/10.4062/biomolther.2021.012

Neuronal Autophagy: Characteristic Features and Roles in Neuronal Pathophysiology  

Valencia, McNeil (College of Pharmacy, Chung-Ang University)
Kim, Sung Rae (College of Pharmacy, Chung-Ang University)
Jang, Yeseul (College of Pharmacy, Chung-Ang University)
Lee, Sung Hoon (College of Pharmacy, Chung-Ang University)
Publication Information
Biomolecules & Therapeutics / v.29, no.6, 2021 , pp. 605-614 More about this Journal
Abstract
Autophagy is an important degradative pathway that eliminates misfolded proteins and damaged organelles from cells. Autophagy is crucial for neuronal homeostasis and function. A lack of or deficiency in autophagy leads to the accumulation of protein aggregates, which are associated with several neurodegenerative diseases. Compared with non-neuronal cells, neurons exhibit rapid autophagic flux because damaged organelles or protein aggregates cannot be diluted in post-mitotic cells; because of this, these cells exhibit characteristic features of autophagy, such as compartment-specific autophagy, which depends on polarized structures and rapid autophagy flux. In addition, neurons exhibit compartment-specific autophagy, which depends on polarized structures. Neuronal autophagy may have additional physiological roles other than amino acid recycling. In this review, we focus on the characteristics and regulatory factors of neuronal autophagy. We also describe intracellular selective autophagy in neurons and its association with neurodegenerative diseases.
Keywords
Neurons; Autophagy; Characteristic; Selective autophagy; Neurological disorder;
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