Crotamiton, an Anti-Scabies Agent, Suppresses Histamine- and Chloroquine-Induced Itch Pathways in Sensory Neurons and Alleviates Scratching in Mice |
Choi, Da-Som
(College of Pharmacy, Gachon University)
Ji, Yeounjung (College of Pharmacy, Gachon University) Jang, Yongwoo (Department of Biomedical Engineering, Hanyang University) Lee, Wook-Joo (College of Pharmacy, Gachon University) Shim, Won-Sik (College of Pharmacy, Gachon University) |
1 | Akiyama, T., Ivanov, M., Nagamine, M., Davoodi, A., Carstens, M. I., Ikoma, A., Cevikbas, F., Kempkes, C., Buddenkotte, J., Steinhoff, M. and Carstens, E. (2016) Involvement of TRPV4 in serotoninevoked scratching. J. Invest. Dermatol. 136, 154-160. DOI |
2 | Cho, Y., Jang, Y., Yang, Y. D., Lee, C. H., Lee, Y. and Oh, U. (2010) TRPM8 mediates cold and menthol allergies associated with mast cell activation. Cell Calcium 48, 202-208. DOI |
3 | Couperus, M. (1949) The use of N-ethyl-o-crotonotoluidide in the treatment of scabies and various pruritic dermatoses. J. Invest. Dermatol. 13, 35-42. DOI |
4 | Goldust, M., Rezaee, E. and Raghifar, R. (2014) Comparison of oral ivermectin versus crotamiton 10% cream in the treatment of scabies. Cutan. Ocul. Toxicol. 33, 333-336. DOI |
5 | Guler, A. D., Lee, H., Iida, T., Shimizu, I., Tominaga, M. and Caterina, M. (2002) Heat-evoked activation of the ion channel, TRPV4. J. Neurosci. 22, 6408-6414. DOI |
6 | Jang, Y., Jung, J., Kim, H., Oh, J., Jeon, J. H., Jung, S., Kim, K. T., Cho, H., Yang, D. J., Kim, S. M., Kim, I. B., Song, M. R. and Oh, U. (2012) Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth. J. Biol. Chem. 287, 6014-6024. DOI |
7 | Jang, Y., Lee, W. J., Hong, G. S. and Shim, W. S. (2015) Red ginseng extract blocks histamine-dependent itch by inhibition of H1R/TRPV1 pathway in sensory neurons. J. Ginseng Res. 39, 257-264. DOI |
8 | Larson, P. (2008) Review: topical permethrin was more effective than topical crotamiton or lindane for scabies. Evid. Based Nurs. 11, 47. DOI |
9 | Kittaka, H. and Tominaga, M. (2017) The molecular and cellular mechanisms of itch and the involvement of TRP channels in the peripheral sensory nervous system and skin. Allergol. Int. 66, 22-30. DOI |
10 | Kittaka, H., Yamanoi, Y. and Tominaga, M. (2017) Transient receptor potential vanilloid 4 (TRPV4) channel as a target of crotamiton and its bimodal effects. Pflugers Arch. 469, 1313-1323. DOI |
11 | Lee, Y., Hong, S., Cui, M., Sharma, P. K., Lee, J. and Choi, S. (2015) Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014). Expert Opin. Ther. Pat. 25, 291-318. DOI |
12 | Malin, S. A., Davis, B. M. and Molliver, D. C. (2007) Production of dissociated sensory neuron cultures and considerations for their use in studying neuronal function and plasticity. Nat. Protoc. 2, 152-160. DOI |
13 | Schindelin, J., Rueden, C. T., Hiner, M. C. and Eliceiri, K. W. (2015) The ImageJ ecosystem: an open platform for biomedical image analysis. Mol. Reprod. Dev. 82, 518-529. DOI |
14 | Ohsawa, Y. and Hirasawa, N. (2014) The role of histamine H1 and H4 receptors in atopic dermatitis: from basic research to clinical study. Allergol. Int. 63, 533-542. DOI |
15 | Olatunde, A. and Obih, P. O. (1981) Use and misuse of 4-aminoquinoline antimalarials in tropical Africa and re-examination of itch reaction to these drugs. Trop. Doct. 11, 97-101. DOI |
16 | Pradhananga, S. and Shim, W. S. (2015) Caffeic acid exhibits anti-pruritic effects by inhibition of multiple itch transmission pathways in mice. Eur. J. Pharmacol. 762, 313-321. DOI |
17 | Vay, L., Gu, C. and McNaughton, P. A. (2012) The thermo-TRP ion channel family: properties and therapeutic implications. Br. J. Pharmacol. 165, 787-801. DOI |
18 | Sekine, R., Satoh, T., Takaoka, A., Saeki, K. and Yokozeki, H. (2012) Anti pruritic effects of topical crotamiton, capsaicin, and a corticosteroid on pruritogen-induced scratching behavior. Exp. Dermatol. 21, 201-204. DOI |
19 | Shim, W. S., Tak, M. H., Lee, M. H., Kim, M., Kim, M., Koo, J. Y., Lee, C. H., Kim, M. and Oh, U. (2007) TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase. J. Neurosci. 27, 2331-2337. DOI |
20 | Smith, E. B., King, C. A. and Baker, M. D. (1984) Crotamiton lotion in pruritus. Int. J. Dermatol. 23, 684-685. DOI |
21 | Wilson, S. R., Gerhold, K. A., Bifolck-Fisher, A., Liu, Q., Patel, K. N., Dong, X. and Bautista, D. M. (2011) TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nat. Neurosci. 14, 595-602. DOI |
22 | Veldhuis, N. A., Poole, D. P., Grace, M., McIntyre, P. and Bunnett, N. W. (2015) The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation. Pharmacol. Rev. 67, 36-73. DOI |
23 | White, J. P., Urban, L. and Nagy, I. (2011) TRPV1 function in health and disease. Curr. Pharm. Biotechnol. 12, 130-144. DOI |
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