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4'-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damages  

Yoo, Ok-Kyung (Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University)
Keum, Young-Sam (Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University)
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Biomolecules & Therapeutics / v.27, no.4, 2019 , pp. 381-385 More about this Journal
We attempted to examine anti-inflammatory and anti-oxidant effects of 4'-O-${\beta}$-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage RAW 264.7 cells, it significantly suppressed lipopolysaccharide (LPS)-induced generation of prostaglandin $E_2$ ($PGE_2$) and nitric oxide (NO) through transcriptional inhibition of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). GOMV also scavenged free radicals in vitro, increased NF-E2-related factor 2 (NRF2), and activated antioxidant response element (ARE), thereby resulting in the induction of phase II cytoprotective enzymes in human keratinocyte HaCaT cells. Finally, GOMV significantly protected HaCaT cells against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative intracellular damages. Together, our results illustrate that GOMV possesses anti-inflammatory and anti-oxidant activity.
4'-O-${\beta}$-D-glucosyl-5-O-methylvisamminol (GOMV); Reactive oxygen species (ROS); NF-E2-related factor 2 (NRF2); Antioxidant response element (ARE);
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1 Baek, S. (2011) When signaling kinases meet histones and histone modifiers in the nucleus. Mol. Cell 42, 274-284.   DOI
2 Chang, C. Z. and Wu, S. C. (2016) 4'-O-beta-D-glucosyl-5-O-methylvisamminol, a natural histone H3 phosphorylation epigenetic suppressor, exerts a neuroprotective effect through PI3K/Akt signaling pathway on focal cerebral ischemia in rats. World Neurosurg. 89, 474-488.   DOI
3 Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., Yamamoto, M. and Nabeshima, Y. (1997) An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 236, 313-322.   DOI
4 Kang, J., Chin, Y., Lee, K., Kim, Y., Choi, B. and Keum, Y. (2014) Identification of 4'-O-beta-D-glucosyl-5-O-methylvisamminol as a novel epigenetic suppressor of histone H3 phosphorylation at Ser10 and its interaction with 14-3-3epsilon. Bioorg. Med. Chem. Lett. 24, 4763-4767.   DOI
5 Keum, Y. and Choi, B. (2014) Molecular and chemical regulation of the Keap1-Nrf2 signaling pathway. Molecules 19, 10074-10089.   DOI
6 Kundu, J. and Surh, Y. (2008) Inflammation: gearing the journey to cancer. Mutat. Res. 659, 15-30.   DOI
7 Keum, Y., Kim, H., Bode, A., Surh, Y. and Dong, Z. (2013) UVB-induced COX-2 expression requires histone H3 phosphorylation at Ser10 and Ser28. Oncogene 32, 444-452.   DOI
8 Kim, D., Lee, K., Lee, H. and Lee, C. (2002) Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals. J. Agric. Food. Chem. 50, 3713-3717.   DOI
9 Kim, D., Chun, O., Kim, Y., Moon, H. and Lee, C. (2003) Quantification of polyphenolics and their antioxidant capacity in fresh plums. J. Agric. Food Chem. 51, 6509-6515.   DOI
10 Lee, J., Mailar, K., Yoo, O., Choi, W. and Keum, Y. (2018) Marliolide inhibits skin carcinogenesis by activating NRF2/ARE to induce heme oxygenase-1. Eur. J. Med. Chem. 150, 113-126.   DOI
11 Ma, Q. (2013) Role of Nrf2 in oxidative stress and toxicity. Ann. Rev. Pharm. Toxicol. 53, 401-426.   DOI
12 Schieber, M. and Chandel, N. (2014) ROS function in redox signaling and oxidative stress. Curr. Biol. 24, R453-R462.   DOI