Synthetic 3',4'-Dihydroxyflavone Exerts Anti-Neuroinflammatory Effects in BV2 Microglia and a Mouse Model |
Kim, Namkwon
(Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University)
Yoo, Hyung-Seok (Department of Pharmacy, College of Pharmacy, Kyung Hee University) Ju, Yeon-Joo (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University) Oh, Myung Sook (Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University) Lee, Kyung-Tae (Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University) Inn, Kyung-Soo (Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University) Kim, Nam-Jung (Department of Pharmacy, College of Pharmacy, Kyung Hee University) Lee, Jong Kil (Department of Pharmacy, College of Pharmacy, Kyung Hee University) |
1 | Cherry, J. D., Olschowka, J. A. and O'Banion, M. K. (2014) Neuroinflammation and M2 microglia: the good, the bad, and the inflamed. J. Neuroinflammation 11, 98. DOI |
2 | Chinta, S. J., Ganesan, A., Reis-Rodrigues, P., Lithgow, G. J. and Andersen, J. K. (2013) Anti-inflammatory role of the isoflavone diadzein in lipopolysaccharide-stimulated microglia: implications for Parkinson's disease. Neurotox. Res. 23, 145-153. DOI |
3 | Choi, Y., Lee, M. K., Lim, S. Y., Sung, S. H. and Kim, Y. C. (2009) Inhibition of inducible NO synthase, cyclooxygenase-2 and interleukin-1beta by torilin is mediated by mitogen-activated protein kinases in microglial BV2 cells. Br. J. Pharmacol. 156, 933-940. DOI |
4 | Cunningham, C. (2013) Microglia and neurodegeneration: the role of systemic inflammation. Glia 61, 71-90. DOI |
5 | de Haas, A. H., Boddeke, H. W. and Biber, K. (2008) Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS. Glia 56, 888-894. DOI |
6 | Kim, D. C., Quang, T. H., Oh, H. and Kim, Y. C. (2017) Steppogenin isolated from cudrania tricuspidata shows antineuroinflammatory effects via NF- and MAPK pathways in lps-stimulated bv2 and primary rat microglial cells. Molecules 22, E2130. DOI |
7 | Kim, E. K. and Choi, E. J. (2015) Compromised MAPK signaling in human diseases: an update. Arch. Toxicol. 89, 867-882. DOI |
8 | Kim, S. H., Smith, C. J. and Van Eldik, L. J. (2004) Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production. Neurobiol. Aging 25, 431-439. DOI |
9 | Kim, Y. S., Choi, D. H., Block, M. L., Lorenzl, S., Yang, L., Kim, Y. J., Sugama, S., Cho, B. P., Hwang, O., Browne, S. E., Kim, S. Y., Hong, J. S., Beal, M. F. and Joh, T. H. (2007) A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation. FASEB J. 21, 179-187. DOI |
10 | An, J. Y., Lee, H. H., Shin, J. S., Yoo, H. S., Park, J. S., Son, S. H., Kim, S. W., Yu, J., Lee, J., Lee, K. T. and Kim, N. J. (2017) Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cells. Bioorg. Med. Chem. Lett. 27, 2613-2616. DOI |
11 | Bachstetter, A. D. and Van Eldik, L. J. (2010) The p38 MAP kinase family as regulators of proinflammatory cytokine production in degenerative diseases of the CNS. Aging Dis. 1, 199-211. |
12 | Biber, K., Moller, T., Boddeke, E. and Prinz, M. (2016) Central nervous system myeloid cells as drug targets: current status and translational challenges. Nat. Rev. Drug Discov. 15, 110-124. DOI |
13 | Block, M. L. and Hong, J. S. (2005) Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog. Neurobiol. 76, 77-98. DOI |
14 | Block, M. L., Zecca, L. and Hong, J. S. (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 8, 57-69. DOI |
15 | Bodea, L. G., Wang, Y., Linnartz-Gerlach, B., Kopatz, J., Sinkkonen, L., Musgrove, R., Kaoma, T., Muller, A., Vallar, L., Di Monte, D. A., Balling, R. and Neumann, H. (2014) Neurodegeneration by activation of the microglial complement-phagosome pathway. J. Neurosci. 34, 8546-8556. DOI |
16 | Boje, K. M. (2004) Nitric oxide neurotoxicity in neurodegenerative diseases. Front. Biosci. 9, 763-776. DOI |
17 | Perez-Cano, F. J. and Castell, M. (2016) Flavonoids, inflammation and immune system. Nutrients 8, 659. DOI |
18 | Lee, J. K., Jin, H. K. and Bae, J. S. (2010) Bone marrow-derived mesenchymal stem cells attenuate amyloid beta-induced memory impairment and apoptosis by inhibiting neuronal cell death. Curr. Alzheimer Res. 7, 540-548. |
19 | Lichtenstein, M. P., Carriba, P., Baltrons, M. A., Wojciak-Stothard, B., Peterson, J. R., Garcia, A. and Galea, E. (2010) Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivatives. J. Alzheimers Dis. 22, 1135-1155. |
20 | Liu, S. Y., Xu, P., Luo, X. L., Hu, J. F. and Liu, X. H. (2016) (7R,8S)-Dehydrodiconiferyl alcohol suppresses lipopolysaccharide-induced inflammatory responses in BV2 microglia by inhibiting mapk signaling. Neurochem. Res. 41, 1570-1577. DOI |
21 | Polak, P. E., Lin, S. X., Pelligrino, D. and Feinstein, D. L. (2014) The blood-brain barrier-permeable catechol-O-methyltransferase inhibitor dinitrocatechol suppresses experimental autoimmune encephalomyelitis. J. Neuroimmunol. 276, 135-141. DOI |
22 | Ransohoff, R. M. and Brown, M. A. (2012) Innate immunity in the central nervous system. J. Clin. Invest. 122, 1164-1171. DOI |
23 | Tai, Y., Qiu, Y. and Bao, Z. (2017) Magnesium lithospermate B suppresses lipopolysaccharide-induced neuroinflammation in BV2 microglial cells and attenuates neurodegeneration in lipopolysaccharide-injected mice. J. Mol. Neurosci. 64, 80-92. |
24 | Zeinali, M., Rezaee, S. A. and Hosseinzadeh, H. (2017) An overview on immunoregulatory and anti-inflammatory properties of chrysin and flavonoids substances. Biomed. Pharmacother. 92, 998-1009. DOI |
25 | Zhang, F. X. and Xu, R. S. (2017) Juglanin ameliorates LPS-induced neuroinflammation in animal models of Parkinson's disease and cell culture via inactivating TLR4/NF-kappaB pathway. Biomed. Pharmacother. 97, 1011-1019. |