Tanshinone IIA Protects Endothelial Cells from H2O2-Induced Injuries via PXR Activation |
Zhu, Haiyan
(Department of Pharmacology, Anhui Medical University)
Chen, Zhiwu (Department of Pharmacology, Anhui Medical University) Ma, Zengchun (Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine) Tan, Hongling (Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine) Xiao, Chengrong (Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine) Tang, Xianglin (Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine) Zhang, Boli (Tianjin University of Traditional Chinese Medicine) Wang, Yuguang (Department of Pharmacology, Anhui Medical University) Gao, Yue (Department of Pharmacology, Anhui Medical University) |
1 | Bhattacharyya, A., Lahiry, L., Mandal, D., Sa, G. and Das, T. (2005) Black tea induces tumor cell apoptosis by Bax translocation, loss in mitochondrial transmembrane potential, cytochrome c release and caspase activation. Int. J. Cancer 117, 308-315. DOI |
2 | Cai, H. and Harrison, D. G. (2000) Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ. Res. 87, 840-844. DOI |
3 |
Chan, P., Chen, Y. C., Lin, L. J., Cheng, T. H., Anzai, K., Chen, Y. H., Liu, Z. M., Lin, J. G. and Hong, H. J. (2012) Tanshinone IIA Attenuates |
4 | Cheng, J., Ma, X., Krausz, K. W., Idle, J. R. and Gonzalez, F. J. (2009) Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. Drug Metab. Dispos. 37, 1611-1621. DOI |
5 | Epsztejn, S., Glickstein, H., Picard, V., Slotki, I. N., Breuer, W., Beaumont, C. and Cabantchik, Z. I. (1999) H-ferritin subunit overexpression in erythroid cells reduces the oxidative stress response and induces multidrug resistance properties. Blood 94, 3593-3603. |
6 | Giotakis, J., Gomatos, I. P., Alevizos, L., Georgiou, A. N., Leandros, E., Konstadoulakis, M. M. and Manolopoulos, L. (2010) Bax, cytochrome c, and caspase-8 staining in parotid cancer patients: markers of susceptibility in radiotherapy? Otolaryngol. Head Neck Surg. 142, 605-611. DOI |
7 | Zhang, X., Ma, Z., Liang, Q., Tang, X., Hu, D., Liu, C., Tan, H., Xiao, C., Zhang, B., Wang, Y. and Gao, Y. (2015a) Tanshinone IIA exerts protective effects in a LCA-induced cholestatic liver model associated with participation of pregnane X receptor. J. Ethnopharmacol. 164, 357-367. DOI |
8 | Ramirez-Zavala, B., Mogavero, S., Schöller, E., Sasse, C., Rogers, P. D. and Morschhauser, J. (2014) SAGA/ADA complex subunit Ada2 is required for Cap1- but not Mrr1-mediated upregulation of the Candida albicans multidrug efflux pump MDR1. Antimicrob. Agents Chemother. 58, 5102-5110. DOI |
9 | Shu, M., Hu, X. R., Hung, Z. A., Huang, D. D. and Zhang, S. (2016) Effects of tanshinone IIA on fibrosis in a rat model of cirrhosis through heme oxygenase-1, inflammation, oxidative stress and apoptosis. Mol. Med. Rep. 13, 3036-3042. DOI |
10 | Su, X., Yao, Z., Li, S. and Sun, H. (2016) Synergism of Chinese Herbal Medicine: Illustrated by Danshen Compound. Evid. Based Complement. Alternat. Med. 2016, 7279361. |
11 | Swales, K. E., Moore, R., Truss, N. J., Tucker, A., Warner, T. D., Negishi, M. and Bishop-Bailey, D. (2012) Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress. Cardiovasc. Res. 93, 674-681. DOI |
12 | Zhang, X., Wang, Y., Ma, Z., Liang, Q., Tang, X., Hu, D., Tan, H., Xiao, C. and Gao, Y. (2015b) Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor. Drug Des. Devel. Ther. 9, 6343-6362. |
13 | Zhao, P., Han, T., Guo, J. J., Zhu, S. L., Wang, J., Ao, F., Jing, M. Z., She, Y. L., Wu, Z. H. and Ye, L. B. (2012) HCV NS4B induces apoptosis through the mitochondrial death pathway. Virus Res. 169, 1-7. DOI |
14 | Zhou, T., You, W.-t., Ma, Z.-c., Liang, Q.-d., Tan, H.-l., Xiao, C.-r., Tang, X.-l., Zhang, B.-l., Wang, Y.-g. and Gao, Y. (2016) Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation. Acta Pharmacologica Sinica 37, 177-186. DOI |
15 | Gong, H., Singh, S. V., Singh, S. P., Mu, Y., Lee, J. H., Saini, S. P., Toma, D., Ren, S., Kagan, V. E., Day, B. W., Zimniak, P. and Xie, W. (2006) Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells. Mol. Endocrinol. 20, 279-290. DOI |
16 | Goya, L., Delgado-Andrade, C., Rufian-Henares, J. A., Bravo, L. and Morales, F. J. (2007) Effect of coffee melanoidin on human hepatoma HepG2 cells. Protection against oxidative stress induced by tert-butylhydroperoxide. Mol. Nutr. Food Res. 51, 536-545. DOI |
17 | Hayes, J. D. and Pulford, D. J. (1995) The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit. Rev. Biochem. Mol. Biol. 30, 445-600. DOI |
18 | Hu, Y., Li, R., Yang, H., Luo, H., Chen, Z. (2015) Sirtuin 6 is essential for sodium sulfide-mediated cytoprotectiv effect in ischemia/reperfusion-stimulated brain endothelial cells. J. Stroke Cerebrovasc. Dis. 24, 601-609. DOI |
19 | Irani, K. (2000) Oxidant signaling in vascular cell growth, death, and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling. Circ. Res. 87, 179-183. DOI |
20 | Kliewer, S. A., Goodwin, B. and Willson, T. M. (2002) The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr. Rev. 23, 687-702. DOI |
21 | Valtcheva, N., Primorac, A., Jurisic, G., Hollmén, M. and Detmar, M.. (2013) The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. J. Biol. Chem. 288, 35736-35748. DOI |
22 | Warren, M. C., Bump, E. A., Medeiros, D. and Braunhut, S. J. (2000) Oxidative stress-induced apoptosis of endothelial cells. Free Radic. Biol. Med. 29, 537-547. DOI |
23 | Yang, Y., Duan, W., Liang, Z., Yi, W., Yan, J., Wang, N., Li, Y., Chen, W., Yu, S., Jin, Z. and Yi, D. (2013) Curcumin attenuates endothelial cell oxidative stress injury through Notch signaling inhibition. Cell. Signal. 25, 615-629. DOI |
24 | Yang, Y., Yang, Y., Trent, M. B., He, N., Lick, S. D., Zimniak, P., Awasthi, Y. C. and Boor, P. J. (2004) Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: possible role in human atherosclerosis. Atherosclerosis 173, 211-221. DOI |
25 | Lehmann, J. M., McKee, D. D., Watson, M. A., Willson, T. M., Moore, J. T. and Kliewer, S. A. (1998) The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J. Clin. Invest. 102, 1016-1023. DOI |
26 | Meister, A. and Anderson, M. E. (1983) Glutathione. Annu. Rev. Biochem. 52, 711-760. DOI |
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