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http://dx.doi.org/10.4062/biomolther.2017.119

Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis  

Lim, Chae Jin (Department of Microbiology and Molecular Biology, School of Bioscience and Biotechnology, Chungnam National University)
Lee, Yong-Moon (College of Pharmacy Chungbuk National University)
Kang, Seung Goo (Division of Biomedical Convergence and Institute of Bioscience & Biotechnology, Kangwon National University)
Lim, Hyung W. (Gladstone Institute of Virology and Immunology, Gladstone Institute of Neurological Disease, School of Medicine, Department of Neurology, University of California)
Shin, Kyong-Oh (College of Pharmacy Chungbuk National University)
Jeong, Se Kyoo (Department of Cosmetic Science, Seowon University)
Huh, Yang Hoon (Korea Basic Science Institute)
Choi, Suin (Korea Basic Science Institute)
Kor, Myungho (Peptide R&D Center, Incospharm Corporation)
Seo, Ho Seong (Radiation Biotechnology Research Division, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Park, Byeong Deog (NeoPharm USA)
Park, Keedon (Peptide R&D Center, Incospharm Corporation)
Ahn, Jeong Keun (Department of Microbiology and Molecular Biology, School of Bioscience and Biotechnology, Chungnam National University)
Uchida, Yoshikazu (Department of Dermatology, School of Medicine, University of California, Northern California Institute for Research and Education, Veterans Affairs Medical Center)
Park, Kyungho (Department of Dermatology, School of Medicine, University of California, Northern California Institute for Research and Education, Veterans Affairs Medical Center)
Publication Information
Biomolecules & Therapeutics / v.25, no.5, 2017 , pp. 511-518 More about this Journal
Abstract
Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only maintaining normal cellular functions, but also protecting cellular senescence in skin exposed to UV irradiation. In the present studies, we investigated whether modulation of autophagy induction using a novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl dipeptide-12 (named as Aquatide), suppresses the UVB irradiation-induced skin aging. Treatment with Aquatide directly activates SIRT1 and stimulates autophagy induction in cultured human dermal fibroblasts. Next, we found that Aquatide-mediated activation of SIRT1 increases autophagy induction via deacetylation of forkhead box class O (FOXO) 1. Finally, UVB irradiation-induced cellular senescence measured by $SA-{\beta}-gal$ staining was significantly decreased in cells treated with Aquatide in parallel to occurring SIRT1 activation-dependent autophagy. Together, Aquatide modulates autophagy through SIRT1 activation, contributing to suppression of skin aging caused by UV irradiation.
Keywords
Cutaneous cellular senescence; UV irradiation; Aquatide; SIRT1; Autophagy;
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1 Akritopoulou-Zanze, I., Patel, J. R., Hartandi, K., Brenneman, J., Winn, M., Pratt, J. K., Grynfarb, M., Goos-Nisson, A., Von Geldern, T. W. and Kym P.R. (2004) Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists. Bioorg. Med. Chem. Lett. 14, 2079-2082.   DOI
2 Bonte, F. (2011) Skin moisturization mechanisms: new data. Ann. Pharm. Fr. 69, 135-141.   DOI
3 Borra, M. T., Smith, B. C. and Denu, J. M. (2005) Mechanism of human SIRT1 activation by resveratrol. J. Biol. Chem. 280, 17187-17195.   DOI
4 Lee, B. Y., Han, J. A., Im, J. S., Morrone, A., Johung, K., Goodwin, E. C., Kleijer, W. J., Dimaio, D. and Hwang, E. S. (2006) Senescenceassociated ${\beta}$-galactosidase is lysosomal ${\beta}$-galactosidase. Aging Cell 5, 187-195.   DOI
5 Liebel, F., Kaur, S., Ruvolo, E., Kollias, N. and Southall, M. D. (2012) Irradiation of skin with visible light induces reactive oxygen species and matrix-degrading enzymes. J. Invest. Dermatol. 132, 1901-1907.   DOI
6 Lim, H. W., Kang, S. G., Ryu, J. K., Schilling, B., Fei, M., Lee, I. S., Kehasse, A., Shirakawa, K., Yokoyama, M., Schnolzer, M., Kasler, H. G., Kwon, H. S., Gibson, B. W., Sato, H., Akassoglou, K., Xiao, C., Littman, D. R., Ott, M. and Verdin, E. (2015) SIRT1 deacetylates $ROR{\gamma}t$ and enhances Th17 cell generation. J. Exp. Med. 212, 607-617.   DOI
7 Mizushima, N., Levine, B., Cuervo, A. M. and Klionsky, D. J. (2008) Autophagy fights disease through cellular self-digestion. Nature 451, 1069-1075.   DOI
8 Morselli, E., Maiuri, M. C., Markaki, M., Megalou, E., Pasparaki, A., Palikaras, K., Criollo, A., Galluzzi, L., Malik, S. A., Vitale, I., Michaud, M., Madeo, F., Tavernarakis, N. and Kroemer, G. (2010) Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis. 1, e10.   DOI
9 Morselli, E., Marino, G., Bennetzen, M. V., Eisenberg, T., Megalou, E., Schroeder, S., Cabrera, S., Benit, P., Rustin, P., Criollo, A., Kepp, O., Galluzzi, L., Shen, S., Malik, S. A., Maiuri, M. C., Horio, Y., Lopez-Otin, C., Andersen, J. S., Tavernarakis, N., Madeo, F. and Kroemer, G. (2011) Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J. Cell Biol. 192, 615-629.   DOI
10 Rosette, C. and Karin, M. (1996) Ultraviolet light and osmotic stress:activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 274, 1194-1197.   DOI
11 Rubinsztein, D. C., Marino, G. and Kroemer, G. (2011) Autophagy and aging. Cell 146, 682-695.   DOI
12 Uchida, Y., Houben, E., Park, K., Douangpanya, S., Lee, Y. M., Wu, B. X., Hannun, Y. A., Radin, N. S., Elias, P. M. and Holleran, W. M. (2010) Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB. J. Invest. Dermatol. 130, 2472-2480.   DOI
13 Sakai, T., Matsumoto, Y., Ishikawa, M., Sugita, K., Hashimoto, Y., Wakai, N., Kitao, A., Morishita, E., Toyoshima, C., Hayashi, T. and Akiyama, T. (2015) Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton. Bioorg. Med. Chem. 23, 328-339.   DOI
14 Sanches Silveira, J. E. and Myaki Pedroso, D. M. (2014) UV light and skin aging. Rev. Environ. Health 29, 243-254.
15 Sun R., Celli A., Crumrine D., Hupe M., Adame L.C., Pennypacker S.D., Park K., Uchida Y., Feingold K.R., Elias P.M., Ilic D. and Mauro T.M. (2015) Lowered humidity produces human epidermal equivalents with enhanced barrier properties. Tissue Eng. Part C Methods 21, 15-22.   DOI
16 Wang, S.S. (1973) p-Alkoxybenzyl Alcohol Resin and p-Alkoxybenzyloxycarbonylhydrazide Resin for Solid Phase Synthesis of Protected Peptide Fragments. J. Am. Chem. Soc. 95, 1328-1333.   DOI
17 Cherng, J. Y., Chen, L. Y. and Shih, M. F. (2012) Preventive effects of ${\beta}$-thujaplicin against UVB-induced MMP-1 and MMP-3 mRNA expressions in skin fibroblasts. Am. J. Chin. Med. 40, 387-398.   DOI
18 Zhang, J., Zhang, Y., Xiao, F., Liu, Y., Wang, J., Gao, H., Rong, S., Yao, Y., Li, J. and Xu, G. (2016) The peroxisome proliferator-activated receptor ${\gamma}$ agonist pioglitazone prevents NF-${\kappa}B$ activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway. Biochem. Pharmacol. 101, 100-111.   DOI
19 Lapaquette, P., Guzzo, J., Bretillon, L. and Bringer, M. A. (2015) Cellular and molecular connections between autophagy and inflammation. Mediators Inflamm. 2015, 398483.
20 Boya, P., Reggiori, F. and Codogno, P. (2013) Emerging regulation and functions of autophagy. Nat. Cell Biol. 15, 713-720.   DOI
21 Denda, M., Tsuchiya, T., Elias, P. M. and Feingold, K. R. (2000) Stress alters cutaneous permeability barrier homeostasis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278, R367-R372.   DOI
22 Donmez, G. and Guarente, L. (2010) Aging and disease: connections to sirtuins. Aging Cell 9, 285-290.   DOI
23 Haigis, M. C. and Sinclair, D. A. (2010) Mammalian sirtuins: biological insights and disease relevance. Annu. Rev. Pathol. 5, 253-295.   DOI
24 Holleran, W. M., Uchida, Y., Halkier-Sorensen, L., Haratake, A., Hara, M., Epstein, J. H. and Elias, P. M. (1997) Structural and biochemical basis for the UVB-induced alterations in epidermal barrier function. Photodermatol. Photoimmunol. Photomed. 13, 117-128.   DOI
25 Huang, H. and Tindall, D. J. (2007) Dynamic FoxO transcription factors. J. Cell Sci. 120, 2479-2487.   DOI
26 Park, K., Ikushiro, H., Seo, H. S., Shin, K. O., Kim, Y. I., Kim, J. Y., Lee, Y. M., Yano, T., Holleran, W. M., Elias, P. and Uchida, Y. (2016) ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. Proc. Natl. Acad. Sci. U.S.A. 113, E1334-E1342.   DOI
27 Nagar, R. (2017) Autophagy: A brief overview in perspective of dermatology. Indian J. Dermatol. Venereol. Leprol. 83, 290-297.   DOI
28 Ng, F. and Tang, B. L. (2013) Sirtuins' modulation of autophagy. J. Cell Physiol. 228, 2262-2270.   DOI
29 Park, K., Elias, P. M., Hupe, M., Borkowski, A. W., Gallo, R. L., ShiN, K. O., Lee, Y. M., Holleran, W. M. and Uchida, Y. (2013) Resveratrol stimulates sphingosine-1-phosphate signaling of cathelicidin production. J. Invest. Dermatol. 133, 1942-1949.   DOI
30 Qiu, G., Li, X., Che, X., Wei, C., He, S., Lu, J., Jia, Z., Pang, K. and Fan, L. (2015) SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment. FEBS Lett. 589, 2034-2042.   DOI
31 Rinnerthaler, M., Bischof, J., Streubel, M. K., Trost, A. and Richter, K. (2015) Oxidative stress in aging human skin. Biomolecules 5, 545-589.   DOI
32 Rittie, L. and Fisher, G. J. (2002) UV-light-induced signal cascades and skin aging. Ageing Res. Rev. 1, 705-720.   DOI