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http://dx.doi.org/10.4062/biomolther.2016.126

Production of Recombinant Anti-Cancer Vaccines in Plants  

Lee, Jeong Hwan (Department of Medicine, Therapeutic Protein Engineering Lab, College of Medicine, Chung-Ang University)
Ko, Kisung (Department of Medicine, Therapeutic Protein Engineering Lab, College of Medicine, Chung-Ang University)
Publication Information
Biomolecules & Therapeutics / v.25, no.4, 2017 , pp. 345-353 More about this Journal
Abstract
Plant expression systems have been developed to produce anti-cancer vaccines. Plants have several advantages as bioreactors for the production of subunit vaccines: they are considered safe, and may be used to produce recombinant proteins at low production cost. However, several technical issues hinder large-scale production of anti-cancer vaccines in plants. The present review covers design strategies to enhance the immunogenicity and therapeutic potency of anti-cancer vaccines, methods to increase vaccine-expressing plant biomass, and challenges facing the production of anti-cancer vaccines in plants. Specifically, the issues such as low expression levels and plant-specific glycosylation are described, along with their potential solutions.
Keywords
Cancer; Vaccine; Glycosylation; Plant expression system; Subunit vaccine; Recombinant protein;
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