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http://dx.doi.org/10.4062/biomolther.2016.169

Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein Activation  

Nguyen, Minh Duc (School of Pharmacy, Sungkyunkwan University)
Kim, Hee Ryung (School of Pharmacy, Sungkyunkwan University)
Chung, Ka Young (School of Pharmacy, Sungkyunkwan University)
Publication Information
Biomolecules & Therapeutics / v.25, no.1, 2017 , pp. 4-11 More about this Journal
Abstract
Heterotrimeric G proteins are key intracellular coordinators that receive signals from cells through activation of cognate G protein-coupled receptors (GPCRs). The details of their atomic interactions and structural mechanisms have been described by many biochemical and biophysical studies. Specifically, a framework for understanding conformational changes in the receptor upon ligand binding and associated G protein activation was provided by description of the crystal structure of the ${\beta}2$-adrenoceptor-Gs complex in 2011. This review focused on recent findings in the conformational dynamics of G proteins and GPCRs during activation processes.
Keywords
G protein; G protein-coupled receptor; Structure; Dynamics;
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