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http://dx.doi.org/10.4062/biomolther.2014.134

Effects of Baicalin on Oral Pharmacokinetics of Caffeine in Rats  

Noh, Keumhan (College of Pharmacy, Yeungnam University)
Nepal, Mahesh Raj (College of Pharmacy, Yeungnam University)
Jeong, Ki Sun (College of Pharmacy, Yeungnam University)
Kim, Sun-A (College of Pharmacy, Yeungnam University)
Um, Yeon Ji (College of Pharmacy, Yeungnam University)
Seo, Chae Shin (College of Pharmacy, Yeungnam University)
Kang, Mi Jeong (College of Pharmacy, Yeungnam University)
Park, Pil-Hoon (College of Pharmacy, Yeungnam University)
Kang, Wonku (College of Pharmacy, Chung-Ang University)
Jeong, Hye Gwang (College of Pharmacy, Chungnam National University)
Jeong, Tae Cheon (College of Pharmacy, Yeungnam University)
Publication Information
Biomolecules & Therapeutics / v.23, no.2, 2015 , pp. 201-206 More about this Journal
Abstract
Scutellaria baicalensis is one of the most widely used herbal medicines in East Asia. Because baicalein and baicalin are major components of this herb, it is important to understand the effects of these compounds on drug metabolizing enzymes, such as cytochrome P450 (CYP), for evaluating herb-drug interaction. The effects of baicalin and baicalein on activities of ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD), benzyloxyresorufin O-debenzylase (BROD), p-nitrophenol hydroxylase and erythromycin N-demethylase were assessed in rat liver microsomes in the present study. In addition, the pharmacokinetics of caffeine and its three metabolites (i.e., paraxanthine, theobromine and theophylline) in baicalin-treated rats were compared with untreated control. As results, EROD, MROD and BROD activities were inhibited by both baicalin and baicalein. However, there were no significant differences in the pharmacokinetic parameters of oral caffeine and its three metabolites between control and baicalin-treated rats. When the plasma concentration of baicalin was determined, the maximum concentration of baicalin was below the estimated $IC_{50}$ values observed in vitro. In conclusion, baicalin had no effects on the pharmacokinetics of caffeine and its metabolites in vivo, following single oral administration in rats.
Keywords
Baicalin; Baicalein; Caffeine; Drug interaction; Pharmacokinetics;
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