[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.4062/biomolther.2014.105

Non-Thermal Atmospheric-Pressure Plasma Possible Application in Wound Healing

Haertel, Beate (Department of Pharmaceutical Biology, Institute of Pharmacy, Ernst-Moritz-Arndt University of Greifswald)
von Woedtke, Thomas (Leibniz Institute of Plasma Science and Technology Greifswald e.V (INP))
Weltmann, Klaus-Dieter (Leibniz Institute of Plasma Science and Technology Greifswald e.V (INP))
Lindequist, Ulrike (Department of Pharmaceutical Biology, Institute of Pharmacy, Ernst-Moritz-Arndt University of Greifswald)

Publication Information

Biomolecules & Therapeutics / v.22, no.6, 2014 , pp. 477-490 More about this Journal

Abstract

Non-thermal atmospheric-pressure plasma, also named cold plasma, is defined as a partly ionized gas. Therefore, it cannot be equated with plasma from blood; it is not biological in nature. Non-thermal atmospheric-pressure plasma is a new innovative approach in medicine not only for the treatment of wounds, but with a wide-range of other applications, as e.g. topical treatment of other skin diseases with microbial involvement or treatment of cancer diseases. This review emphasizes plasma effects on wound healing. Non-thermal atmospheric-pressure plasma can support wound healing by its antiseptic effects, by stimulation of proliferation and migration of wound relating skin cells, by activation or inhibition of integrin receptors on the cell surface or by its pro-angiogenic effect. We summarize the effects of plasma on eukaryotic cells, especially on keratinocytes in terms of viability, proliferation, DNA, adhesion molecules and angiogenesis together with the role of reactive oxygen species and other components of plasma. The outcome of first clinical trials regarding wound healing is pointed out.

Keywords

Angiogenesis; Cell surface molecules; Cell viability; Non-thermal atmospheric-pressure plasma; Plasma-cell interaction; Reactive oxygen species; Wound healing;

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Times Cited By KSCI : 2 (Citation Analysis)

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4	(2014) Plasma sources science & technology Time-resolved characterization of a free plasma jet formed off the surface of a piezoelectric crystal / 29 (4) , 045016
3	(2020) Plasma chemistry and plasma processing A Dielectric Barrier Discharge Plasma Degrades Proteins to Peptides by Cleaving the Peptide Bond / 40 (3) , 685
None	(2014) IOP conference series. Materials science and engineering Effect of DC micro-plasma treatment on bacteria in its vegetative bacteria / 863 (None) , 012031
12	(2020) International journal of molecular sciences Anticancer Effects of Cold Atmospheric Plasma in Canine Osteosarcoma Cells / 21 (12) , 4556
21	(2020) Journal of physics. D, applied physics Effect of external axial magnetic field on a helium atmospheric pressure plasma jet and plasma-treated water / 53 (21) , 215202
3	(2020) International wound journal The efficacy and safety of cold atmospheric plasma as a novel therapy for diabetic wound in vitro and in vivo / 17 (3) , 851
13	(2014) International journal of molecular sciences Positive Effect of Cold Atmospheric Nitrogen Plasma on the Behavior of Mesenchymal Stem Cells Cultured on a Bone Scaffold Containing Iron Oxide-Loaded Silica Nanoparticles Catalyst / 21 (13) , 4738
7	(2020) Jama network open Effect of Cold Atmospheric Plasma Therapy vs Standard Therapy Placebo on Wound Healing in Patients With Diabetic Foot Ulcers : A Randomized Clinical Trial / 3 (7) , e2010411
7	(2014) Microorganisms Effects of Plasma-Activated Water on Skin Wound Healing in Mice / 8 (7) , 1091
9	(2014) Water Influence of Plasma-Activated Water on Physical and Physical-Chemical Soil Properties / 12 (9) , 2357
None	(2014) Redox biology Non-thermal dielectric-barrier discharge plasma induces reactive oxygen species by epigenetically modifying the expression of NADPH oxidase family genes in keratinocytes / 37 (None) , 101698
5	(2020) International wound journal The effect of non‐thermal atmospheric pressure plasma application on wound healing after gingivectomy / 17 (5) , 1376
10	(2014) Plasma sources science & technology The formation of atomic oxygen and hydrogen in atmospheric pressure plasmas containing humidity: picosecond two-photon absorption laser induced fluorescence and numerical simulations / 29 (10) , 105001
4	(2020) Biomedical engineering Cold Plasma Treatment Accelerates Regeneration of the Skin after Mechanical Damage / 54 (4) , 267
None	(2014) IOP conference series. Materials science and engineering The Effect of Plasma Treatment on the Speed of Healing of Wounds Similar to battle wounds / 928 (None) , 072103
None	(2014) IOP conference series. Materials science and engineering The Effect of Plasma Treatment on the Speed of Healing of Wounds Similar to battle wounds / 928 (None) , 072103
11	(2014) ECS journal of solid state science and technology : jss Analysis of Hydroxyl Radical and Hydrogen Peroxide Generated in Helium-Based Atmospheric-Pressure Plasma Jet and in Different Solutions Treated by Plasma for Bioapplications / 9 (11) , 115002
11	(2020) Polymers Thin Film Deposition by Atmospheric Pressure Dielectric Barrier Discharges Containing Eugenol: Discharge and Coating Characterizations / 12 (11) , 2692
None	(2014) Scientific reports TRPA1 and TRPV1 channels participate in atmospheric-pressure plasma-induced [Ca <SUP>2+</SUP> ] <SUB>i</SUB> response / 10 (None) , 9687
12	(2014) Plants Effects of Nonthermal Plasma on Morphology, Genetics and Physiology of Seeds: A Review / 9 (12) , 1736
12	(2020) Japanese journal of applied physics Wound treatment by low-temperature atmospheric plasmas and issues in plasma engineering for plasma medicine / 59 (12) , 120501
9	(2021) Plastic and reconstructive surgery. Global open Efficacy of Low-temperature Plasma for Treatment of Facial Rejuvenation in Asian Population / 9 (9) , e3812
13	(2014) Medicine Cell cycle regulation in human hair follicle dermal papilla cells using nonthermal atmospheric pressure plasma-activated medium / 100 (13) , e25409
10	(2014) 藥學雜誌 Molecular Mechanisms Underlying Cellular Responses to the Loading of Non-thermal Atmospheric Pressure Plasma-activated Solutions / 141 (10) , 1185
12	(2021) 藥學雜誌 Generation, Detection and Bio-protection of Reactive Oxygen Species/Free Radicals / 141 (12) , 1359
None	(2014) Oxidative medicine and cellular longevity Redox Enzymes of the Thioredoxin Family as Potential and Novel Markers in Pemphigus / 2021 (None) , 1
None	(2014) Oxidative medicine and cellular longevity Head and Neck Cancer Cell Death due to Mitochondrial Damage Induced by Reactive Oxygen Species from Nonthermal Plasma-Activated Media: Based on Transcriptomic Analysis / 2021 (None) , 1
2	(2021) Journal of cosmetic dermatology : the official journal of the European Society for Cosmetic & Aesthetic Dermatology Transdermal delivery of topical lidocaine in a mouse model is enhanced by treatment with cold atmospheric plasma / 20 (2) , 626
3	(2014) Applied sciences Analysing Mouse Skin Cell Behaviour under a Non-Thermal kHz Plasma Jet / 11 (3) , 1266
9	(2014) International journal of molecular sciences The Effect of Non-Thermal Plasma on the Structural and Functional Characteristics of Human Spermatozoa / 22 (9) , 4979
2	(2014) Japanese journal of applied physics Molecular mechanisms of non-thermal atmospheric pressure plasma-induced cellular responses / 60 (2) , 020501
16	(2014) Journal of applied physics Selective inhibition of melanoma and basal cell carcinoma cells by short-lived species, long-lived species, and electric fields generated from cold plasma / 129 (16) , 163302
9	(2014) Energies Fabrication of Photoactive Electrospun Cellulose Acetate Nanofibers for Antibacterial Applications / 14 (9) , 2598
12	(2014) Applied sciences Non-Thermal Atmospheric Pressure Argon-Sourced Plasma Flux Promotes Wound Healing of Burn Wounds and Burn Wounds with Infection in Mice through the Anti-Inflammatory Macrophages / 11 (12) , 5343
12	(2014) Applied sciences Inhibitory Effect of Cold Atmospheric Plasma on Chronic Wound-Related Multispecies Biofilms / 11 (12) , 5441
6	(2014) Biomolecules Cold Atmospheric Plasma Promotes the Immunoreactivity of Granulocytes In Vitro / 11 (6) , 902
16	(2014) Molecules Moving toward a Handheld “Plasma” Spectrometer for Elemental Analysis, Putting the Power of the Atom (Ion) in the Palm of Your Hand / 26 (16) , 4761
2	(2014) Synthesis lectures on mechanical engineering Cold Atmospheric Plasma (CAP) Technology and Applications / 6 (2) , i
9	(2014) Journal of cosmetic dermatology : the official journal of the European Society for Cosmetic & Aesthetic Dermatology Analgesic effect of topical lidocaine is enhanced by cold atmospheric plasma pretreatment in facial CO<SUB>2</SUB> laser treatments / 20 (9) , 2794
9	(2021) Plasma sources science & technology Energy efficiency of voltage waveform tailoring for the generation of excited species in RF plasma jets operated in He/N<SUB>2</SUB> mixtures / 30 (9) , 095013
9	(2014) Chemistry letters Flow Spin-trapping ESR Detection of •OH and •H Radicals Derived from Helium Atmospheric-pressure Plasma at Gas-Liquid Interface Employing a Micro Open-flow Reactor / 50 (9) , 1628
5	(2014) Applied science and convergence technology Plasma Bioscience and Medicines / 30 (5) , 118
20	(2014) Applied sciences Anti-Bacterial Action of Plasma Multi-Jets in the Context of Chronic Wound Healing / 11 (20) , 9598
19	(2014) International journal of molecular sciences Microplasma Treatment versus Negative Pressure Therapy for Promoting Wound Healing in Diabetic Mice / 22 (19) , 10266
6	(2014) Dermatologic therapy The evaluation of efficacy of atmospheric pressure plasma in diabetic ulcers healing: A randomized clinical trial / 34 (6) , e15169
11	(2014) Biomedicines The Anti-Fibrotic Effect of Cold Atmospheric Plasma on Localized Scleroderma In Vitro and In Vivo / 9 (11) , 1545
61	(2014) RSC advances Non-thermal atmospheric pressure plasma as a powerful tool for the synthesis of rhenium-based nanostructures for the catalytic hydrogenation of 4-nitrophenol / 11 (61) , 38596
2	(2014) Applied sciences Cold Atmospheric Plasma, Platelet-Rich Plasma, and Nitric Oxide Synthesis Inhibitor: Effects Investigation on an Experimental Model on Rats / 12 (2) , 590
1	(2022) Nanomaterials Improvement of Nanostructured Polythiophene Film Uniformity Using a Cruciform Electrode and Substrate Rotation in Atmospheric Pressure Plasma Polymerization / 12 (1) , 32
None	(2014) Bioelectrochemistry Cold helium plasma jet does not stimulate collagen remodeling in a 3D human dermal substitute / 143 (None) , 107985