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http://dx.doi.org/10.4062/biomolther.2011.19.3.274

Herbs for the Treatment of Insomnia  

Kim, Chung-Soo (College of Pharmacy and Medical Research Center (CICT))
Han, Jin-Yi (Research Institute of Veterinary Medicine, Chungbuk National University)
Kim, Seung-Hwan (College of Physical Education, KyungHee University)
Hong, Jin-Tae (College of Pharmacy and Medical Research Center (CICT))
Oh, Ki-Wan (College of Pharmacy and Medical Research Center (CICT))
Publication Information
Biomolecules & Therapeutics / v.19, no.3, 2011 , pp. 274-281 More about this Journal
Abstract
Pharmacological approaches have been included in conventional medical treatment for insomnia or sleep disorders. However, long-term use of frequently prescribed medications can often lead to habituation, critical withdrawal symptoms and/or side effects. Some individuals with insomnia or trouble sleeping have used complementary and alternative medicine (CAM) therapies to treat their conditions. Recently, CAMs or herbs have been attractive alternative medications to many patients with sleep disorders who may be averse to using conventional drugs. We reviewed the most widely available sleep-promoting herbs commonly used in the western and oriental countries.
Keywords
Insomnia; Sleep; Complementary; Alternative; Medicine; Herbal treatments;
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1 Nguyen, T. T., Matsumoto, K., Yamasaki, K., Nguyen, M. D., Nguyen, T. N. and Watanabe, H. (1996) Effects of majonoside-R2 on pentobarbital sleep and gastric lesion in psychologically stressed mice. Pharmacol. Biochem. Behav. 53, 957-963.   DOI
2 Ohta, T. (1996) Recent progress in development of psychotropic drugs (5)--Hypnotics. Nihon Shinkei Seishin Yakurigaku Zasshi 16, 161-170.
3 Okuyama, E., Ebihara, H., Takeuchi, H. and Yamazaki, M. (1999) Adenosine, the anxiolytic-like principle of the Arillus of Euphoria longana. Planta. Med. 65, 115-119.   DOI
4 Pallesen, S., Bjorvatn, B., Nordhus, I. H. and Skjerve, A. (2002) Valerian as a sleeping aid?. Tidsskr. Nor. Laegeforen. 122, 2857-2859.
5 Pearson, N. J., Johnson, L. L. and Nahin, R. L. (2006) Insomnia, trouble sleeping, and complementary and alternative medicine: Analysis of the 2002 national health interview survey data. Arch. Intern. Med. 166, 1775-1782.   DOI
6 Lee, S. P., Honda, K., Rhee, Y. H. and Inoue, S. (1990) Chronic intake of panax ginseng extract stabilizes sleep and wakefulness in fooddeprived rats. Neurosci. Lett. 111, 217-221.   DOI
7 Lee, S. S., Lin, B. F. and Liu, K. C. (1996) Three triterpene esters from Zizyphus jujuba. Phytochemistry 43, 847-851.   DOI
8 Liu, Y. W., Li, J. and Ye, J. H. (2010) Histamine regulates activities of neurons in the ventrolateral preoptic nucleus. J. Physiol. 588, 4103-4116.   DOI
9 Ma, Y., Eun, J. S., Cheong, J. H., Rhee, D. K., Hong, J. T. and Oh, K. W. (2008) Korea Red Ginseng Alters Electroencephalogram Spectra of Sleep-Wake Stage in Rats. J. Ginseng Res. 32, 179-281.   과학기술학회마을   DOI
10 Ma, Y., Han, H., Eun, J. S., Kim, H. C., Hong, J. T. and Oh, K. W. (2007) Sanjoinine A isolated from Zizyphi Spinosi Semen augments pentobarbital- induced sleeping behaviors through the modifi cation of GABA-ergic systems. Biol. Pharm. Bull. 30, 1748-1753.   DOI
11 Ma, Y., Ma, H., Eun, J. S., Nam, S. Y., Kim, Y. B., Hong, J. T., Lee, M. K. and Oh, K. W. (2009) Methanol extract of Longanae Arillus augments pentobarbital-induced sleep behaviors through the modifi - cation of GABAergic systems. J. Ethnopharmacol. 122, 245-250.   DOI
12 McCarley, R. W. (2007) Neurobiology of REM and NREM sleep. Sleep Med. 8, 302-330.   DOI
13 McGinty, D. and Szymusiak, R. (2001) Brain structures and mechanisms involved in the generation of NREM sleep: focus on the preoptic hypothalamus. Sleep Med. Rev. 5, 323-342.   DOI
14 Meier, P. J., Ziegler, W. H. and Neftel, K. (1988) Benzodiazepine--practice and problems of its use. Schweiz Med. Wochenschr. 118, 381-392.
15 Mendelson, W. B. (2001) Neurotransmitters and sleep. J. Clin. Psychiatry 62(Suppl 10), 5-8.
16 Khom, S., Baburin, I., Timin, E., Hohaus, A., Trauner, G., Kopp, B. and Hering, S. (2007) Valerenic acid potentiates and inhibits GABA(A) receptors: molecular mechanism and subunit specifi city. Neuropharmacol. 53, 178-187.   DOI
17 Kimura, T., Saunders, P. A., Kim, H. S., Rheu, H. M., Oh, K. W. and Ho, I. K. (1994) Interactions of ginsenosides with ligand-bindings of GABA(A) and GABA(B) receptors. Gen. Pharmacol. 25, 193-199.   DOI   ScienceOn
18 Koetter, U., Schrader, E., Kaufeler, R. and Brattstrom, A. (2007) A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical effi cacy of a fi xed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder. Phytother. Res. 21, 847-851.   DOI
19 Kubin, A., Wierrani, F., Burner, U., Alth, G. and Grunberger, W. (2005). Hypericin--the facts about a controversial agent. Curr. Pharm. Des. 11, 233-253.   DOI
20 Krenn, L. (2002) Passion Flower (Passifl ora incarnata L.)--a reliable herbal sedative. Wien. Med. Wochenschr. 152, 404-406.   DOI
21 Kuroda, K., Inoue, N., Ito, Y., Kubota, K., Sugimoto, A., Kakuda, T. and Fushiki, T. (2005) Sedative effects of the jasmine tea odor and (R)- (-)-linalool, one of its major odor components, on autonomic nerve activity and mood states. Eur. J. Appl. Physiol. 95, 107-114.   DOI   ScienceOn
22 Langosch, J. M., Zhou, X. Y., Heinen, M., Kupferschmid, S., Chatterjee, S. S., Noldner, M. and Walden, J. (2002) St John's wort (Hypericum perforatum) modulates evoked potentials in guinea pig hippocampal slices via AMPA and GABA receptors. Eur. Neuropsychopharmacol. 12, 209-216.
23 Lanquart, J. P., Kerkhofs, M., Stanus, E., Mendlewicz, J. and Linkowski, P. (1996) Sleep EEG analysis by linear prediction: frequency changes of slow-wave activity within NREM and REM sleep episodes in healthy men. Neuropsychobiol. 34, 1-8.
24 Larzelere, M. M. and Wiseman, P. (2002) Anxiety, depression, and insomnia. Prim Care 29, 339-360, vii.   DOI   ScienceOn
25 Gobbi, M., Moia, M., Pirona, L., Morizzoni, P. and Mennini, T. (2001) In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/ benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters. Pharmacopsychiatry 34(Suppl 1), S45-48.
26 Gurley, B. J., Swain, A., Hubbard, M. A., Williams, D. K., Barone, G., Hartsfi eld, F., Tong, Y., Carrier, D. J., Cheboyina, S. and Battu, S. K. (2008) Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea. Mol. Nutr. Food Res. 52, 755-763.   DOI
27 Huang, L., Liu, J., Li, D., Wang, Z., Ye, W., Cai, B., Liu, M. and Li, M. (1991) A study on components and compound prescription of huangqin decoction. Zhongguo. Zhong. Yao. Za. Zhi. 16, 177-181, back cover.
28 Harris, C. D. (2005) Neurophysiology of sleep and wakefulness. Respir. Care Clin. N. Am. 11, 567-586.
29 Hartley, D. E., Elsabagh, S. and File, S. E. (2004) Gincosan (a combination of Ginkgo biloba and Panax ginseng): the effects on mood and cognition of 6 and 12 weeks' treatment in post-menopausal women. Nutr. Neurosci. 7, 325-333.   DOI
30 Hayaishi, O. (2000) Molecular mechanisms of sleep-wake regulation: a role of prostaglandin D2. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 355, 275-280.   DOI
31 Kabalak, A. A., Soyal, O. B., Urfalioglu, A., Saracoglu, F. and Gogus, N. (2004) Menometrorrhagia and tachyarrhythmia after using oral and topical ginseng. J. Womens Health (Larchmt) 13, 830-833.   DOI
32 Kaku, T., Miyata, T., Uruno, T., Sako, I. and Kinoshita, A. (1975) Chemico- pharmacological studies on saponins of Panax ginseng C. A. Meyer. II. Pharmacological part. Arzneimittelforschung 25, 539-547.
33 Dijk, D. J. (2010) Sleep variety: physiology, psychology and epidemiology. J. Sleep Res. 19, 381-383.   DOI
34 Dinh, L. D., Simmen, U., Bueter, K. B., Bueter, B., Lundstrom, K. and Schaffner, W. (2001) Interaction of various Piper methysticum cultivars with CNS receptors in vitro. Planta. Med. 67, 306-311.   DOI
35 Doi, Y., Minowa, M., Okawa, M. and Uchiyama, M. (2000) Prevalence of sleep disturbance and hypnotic medication use in relation to sociodemographic factors in the general Japanese adult population. J. Epidemiol. 10, 79-86.   DOI   ScienceOn
36 Eytan, A., Haller, D. M., Wolff, H., Cerutti, B., Sebo, P., Bertrand, D. and Niveau, G. (2011) Psychiatric symptoms, psychological distress and somatic comorbidity among remand prisoners in Switzerland. Int. J. Law Psychiatry 34, 13-19.   DOI
37 Dugoua, J. J., Mills, E., Perri, D. and Koren, G. (2006) Safety and effi - cacy of St. John's wort (hypericum) during pregnancy and lactation. Can. J. Clin. Pharmacol. 13, e268-276.
38 Edwards, B. A., O'Driscoll, D. M., Ali, A., Jordan, A. S., Trinder, J. and Malhotra, A. (2010) Aging and sleep: physiology and pathophysiology. Semin. Respir. Crit. Care Med. 31, 618-633.   DOI
39 Escourrou, P., Luriau, S., Rehel, M., Nedelcoux, H. and Lanoe, J. L. (2000) Needs and costs of sleep monitoring. Stud. Health Technol. Inform. 78, 69-85.
40 Gale, C. and Oakley-Browne, M. (2004) Generalised anxiety disorder. Clin Evid. 1437-1459.
41 Geier, F. P. and Konstantinowicz, T. (2004) Kava treatment in patients with anxiety. Phytother. Res. 18, 297-300.   DOI
42 Gilbert, K. A. and Lydic, R. (1994) Pontine cholinergic reticular mechanisms cause state-dependent changes in the discharge of parabrachial neurons. Am. J. Physiol. 266, R136-150.
43 Carrasco, M. C., Vallejo, J. R., Pardo-de-Santayana, M., Peral, D., Martin, M. A. and Altimiras, J. (2009) Interactions of Valeriana offi cinalis L. and Passifl ora incarnata L. in a patient treated with lorazepam. Phytother. Res. 23, 1795-1796.   DOI   ScienceOn
44 Cheng, D., Lidgard, R. O., Duffi eld, P. H., Duffi eld, A. M. and Brophy, J. J. (1988) Identifi cation by methane chemical ionization gas chromatography/ mass spectrometry of the products obtained by steam distillation and aqueous acid extraction of commercial Piper methysticum. Biomed. Environ. Mass Spectrom. 17, 371-376.   DOI
45 Chung, K. F. and Lee, C. K. (2002) Over-the-counter sleeping pills: a survey of use in Hong Kong and a review of their constituents. Gen. Hosp. Psychiatry. 24, 430-435.   DOI
46 Cheng, H. M., Chiang, L. C., Jan, Y. M., Chen, G. W. and Li, T. C. (2010) The effi cacy and safety of a chinese herbal product (Xiao- Feng-San) for the treatment of refractory atopic dermatitis: a randomized, double-blind, placebo-controlled trial. Int. Arch. Allergy Immunol. 155, 141-148.
47 Cheng, J. T. (2000). Review: drug therapy in Chinese traditional medicine. J. Clin. Pharmacol. 40, 445-450.   DOI   ScienceOn
48 Choi, H. K., Xin, Z. C., Choi, Y. D., Lee, W. H., Mah, S. Y. and Kim, D. K. (1999) Safety and effi cacy study with various doses of SS-cream in patients with premature ejaculation in a double-blind, randomized, placebo controlled clinical study. Int. J. Impot. Res. 11, 261-264.   DOI
49 Daley, M., Morin, C. M., LeBlanc, M., Gregoire, J. P. and Savard, J. (2009) The economic burden of insomnia: direct and indirect costs for individuals with insomnia syndrome, insomnia symptoms, and good sleepers. Sleep 32, 55-64.
50 Dietz, B. M., Mahady, G. B., Pauli, G. F. and Farnsworth, N. R. (2005) Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Brain Res. Mol. Brain Res. 138, 191-197.   DOI
51 Armitage, R. (1995) The distribution of EEG frequencies in REM and NREM sleep stages in healthy young adults. Sleep. 18, 334-341.   DOI
52 Avidan, A. Y. (2005). Sleep disorders in the older patient. Prim. Care 32, 563-586.   DOI   ScienceOn
53 Awad, R., Levac, D., Cybulska, P., Merali, Z., Trudeau, V. L. and Arnason, J. T. (2007). Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. Can. J. Physiol. Pharmacol. 85, 933-942.   DOI
54 Benke, D., Barberis, A., Kopp, S., Altmann, K. H., Schubiger, M., Vogt, K. E., Rudolph, U. and Mohler, H. (2009) GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacol. 56, 174-181.
55 Bailes, S., Baltzan, M., Rizzo, D., Fichten, C. S., Grad, R., Wolkove, N., Creti, L., Amsel, R. and Libman, E. (2009) Sleep disorder symptoms are common and unspoken in Canadian general practice. Fam. Pract. 26, 294-300.   DOI
56 Balderer, G. and Borbely, A. A. (1985) Effect of valerian on human sleep. Psychopharmacol. (Berl). 87, 406-409.   DOI
57 Barnes, J., Anderson, L. A. and Phillipson, J. D. (2001) St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. J. Pharm. Pharmacol. 53, 583-600.   DOI   ScienceOn
58 Bennett, D. A. Jr., Phun, L., Polk, J. F., Voglino, S. A., Zlotnik, V. and Raffa, R. B. (1998) Neuropharmacology of St. John's Wort (Hypericum). Ann. Pharmacother. 32, 1201-1208.   DOI
59 Blatter, M., Hoigne, R., Hess, T., Bickel, M. H., Zoppi, M., Fritschy, D. and Maibach, R. (1988) [Side-effects of frequently administered hypnotics and sedatives as well as of anxiolytics. Results from a Comprehensive Hospital Drug Monitoring (CHDM) program]. Schweiz Med Wochenschr. 118, 1859-1864.
60 Butterweck, V. (2003) Mechanism of action of St John's wort in depression: what is known? CNS Drugs 17, 539-562.   DOI
61 Xuan, T. D., Fukuta, M., Wei, A. C., Elzaawely, A. A., Khanh, T. D. and Tawata, S. (2008) Effi cacy of extracting solvents to chemical components of kava (Piper methysticum) roots. J. Nat. Med. 62, 188-194.   DOI
62 Yang, S. L., Nam, S. Y., Han, J. Y., Kim, J. C., Lee, K., Hong, J. T., Oh, K. W. and Eun, J. S. (2010) Alterations and spontaneous sleep architecture and cortical electroencephalogram power spectra by red ginseng extract via GABAAergic systems. J. Ginseng Res. 34, 304-313.   DOI
63 Yi, P. L., Lin, C. P., Tsai, C. H., Lin, J. G. and Chang, F. C. (2007) The involvement of serotonin receptors in suanzaorentang-induced sleep alteration. J. Biomed. Sci. 14, 829-840.   DOI
64 Yoo, D. Y., Choi, J. H., Kim, W., Yoo, K. Y., Lee, C. H., Yoon, Y. S., Won, M. H. and Hwang, I. K. (2011) Effects of Melissa offi cinalis L. (lemon balm) extract on neurogenesis associated with serum corticosterone and GABA in the mouse dentate gyrus. Neurochem. Res. 36, 250-257.   DOI
65 Yuan, C. S., Dey, L., Wang, A., Mehendale, S., Xie, J. T., Aung, H. H. and Ang-Lee, M. K. (2002) Kavalactones and dihydrokavain modulate GABAergic activity in a rat gastric-brainstem preparation. Planta. Med. 68, 1092-1096.   DOI
66 Takagi, K., Saito, H. and Tsuchiya, M. (1972) Pharmacological studies of Panax Ginseng root: pharmacological properties of a crude saponin fraction. Jpn. J. Pharmacol. 22, 339-346.   DOI
67 Takahashi, K., Kayama, Y., Lin, J. S. and Sakai, K. (2010) Locus coeruleus neuronal activity during the sleep-waking cycle in mice. Neurosci. 169, 1115-1126.   DOI
68 Teufel-Mayer, R. and Gleitz, J. (1997) Effects of long-term administration of hypericum extracts on the affi nity and density of the central serotonergic 5-HT1 A and 5-HT2 A receptors. Pharmacopsychiatry 30 Suppl 2, 113-116.
69 Trauner, G., Khom, S., Baburin, I., Benedek, B., Hering, S. and Kopp, B. (2008) Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid. Planta. Med. 74, 19-24.   DOI
70 Vazquez, I. and Aguera-Ortiz, L. F. (2002) Herbal products and serious side effects: a case of ginseng-induced manic episode. Acta. Psychiatr. Scand. 105, 76-77; discussion 77-78.
71 Wang, W. K., Hsu, T. L., Huang, Z. Y. and Wang, Y. Y. (1995) Collective effect of a Chinese formula--a study of xiao-jian-zhong-tang. Am. J. Chin. Med. 23, 299-304.   DOI
72 Wu, T. Y., Chen, C. P. and Jinn, T. R. (2010) Alzheimer's disease: aging, insomnia and epigenetics. Taiwan J. Obstet. Gynecol. 49, 468-472.   DOI
73 Abebe, W. (2002) Herbal medication: potential for adverse interactions with analgesic drugs. J. Clin. Pharm. Ther. 27, 391-401.   DOI
74 Allison, T. and Goff, W. R. (1972) Electrophysiological studies of the echidna, Tachyglossus aculeatus. 3. Sensory and interhemispheric evoked responses. Arch. Ital. Biol. 110, 195-216.
75 Wheatley, D. (2001a) Kava and valerian in the treatment of stressinduced insomnia. Phytother. Res. 15, 549-551.   DOI
76 Wheatley, D. (2001b) Stress-induced insomnia treated with kava and valerian: singly and in combination. Hum. Psychopharmacol. 16, 353-356.   DOI
77 Wheatley, D. (2005) Medicinal plants for insomnia: a review of their pharmacology, effi cacy and tolerability. J. Psychopharmacol. 19, 414-421.   DOI
78 Soulimani, R., Younos, C., Jarmouni, S., Bousta, D., Misslin, R. and Mortier, F. (1997) Behavioural effects of Passifl ora incarnata L. and its indole alkaloid and fl avonoid derivatives and maltol in the mouse. J. Ethnopharmacol. 57, 11-20.   DOI
79 Stanley, N. (2003) Actigraphy in human psychopharmacology: a review. Hum. Psychopharmacol. 18, 39-49.   DOI
80 Steinfels, G. F., Young, G. A. and Khazan, N. (1980) Diurnal variations in REM and NREM sleep EEG power spectra in the rat. Brain Res. 181, 425-432.   DOI
81 Steininger, T. L., Alam, M. N., Gong, H., Szymusiak, R. and McGinty, D. (1999) Sleep-waking discharge of neurons in the posterior lateral hypothalamus of the albino rat. Brain Res. 840, 138-147.   DOI
82 Suntsova, N., Kumar, S., Guzman-Marin, R., Alam, M. N., Szymusiak, R. and McGinty, D. (2009) A role for the preoptic sleep-promoting system in absence epilepsy. Neurobiol. Dis. 36, 126-141.   DOI
83 Szymusiak, R. and McGinty, D. (2008) Hypothalamic regulation of sleep and arousal. Ann. N. Y. Acad. Sci. 1129, 275-286.   DOI
84 Perez, N. M. and Benedito, M. A. (1997) Activities of monoamine oxidase (MAO) A and B in discrete regions of rat brain after rapid eye movement (REM) sleep deprivation. Pharmacol. Biochem. Behav. 58, 605-608.   DOI
85 Szymusiak, R., Steininger, T., Alam, N. and McGinty, D. (2001) Preoptic area sleep-regulating mechanisms. Arch. Ital. Biol. 139, 77-92.
86 Tadros, M. G., Mohamed, M. R., Youssef, A. M., Sabry, G. M., Sabry, N. A. and Khalifa, A. E. (2009) Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John's wort-induced prepulse inhibition defi cit: a possible role of hyperforin. Behav. Brain Res. 199, 334-339.   DOI
87 Taibi, D. M., Vitiello, M. V., Barsness, S., Elmer, G. W., Anderson, G. D. and Landis, C. A. (2009) A randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomnia. Sleep Med. 10, 319-328.   DOI
88 Ramesh, V., Thakkar, M. M., Strecker, R. E., Basheer, R. and McCarley, R. W. (2004) Wakefulness-inducing effects of histamine in the basal forebrain of freely moving rats. Behav. Brain Res. 152, 271-278.   DOI
89 Rangkadilok, N., Worasuttayangkurn, L., Bennett, R. N. and Satayavivad, J. (2005) Identifi cation and quantifi cation of polyphenolic compounds in Longan (Euphoria longana Lam.) fruit. J. Agric. Food Chem. 53, 1387-1392.   DOI
90 Rhee, Y. H., Lee, S. P., Honda, K. and Inoue, S. (1990) Panax ginseng extract modulates sleep in unrestrained rats. Psychopharmacol. (Berl). 101, 486-488.   DOI
91 Saper, C. B., Chou, T. C. and Scammell, T. E. (2001) The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 24, 726-731.   DOI
92 Shouse, M. N., Staba, R. J., Saquib, S. F. and Farber, P. R. (2000) Monoamines and sleep: microdialysis fi ndings in pons and amygdala. Brain Res. 860, 181-189.   DOI
93 Sharpley, A. L., McGavin, C. L., Whale, R. and Cowen, P. J. (1998) Antidepressant-like effect of Hypericum perforatum (St John's wort) on the sleep polysomnogram. Psychopharmacol. (Berl). 139, 286-287.   DOI
94 Sherin, J. E., Elmquist, J. K., Torrealba, F. and Saper, C. B. (1998) Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat. J. Neurosci. 18, 4705-4721.
95 Shinomiya, K., Inoue, T., Utsu, Y., Tokunaga, S., Masuoka, T., Ohmori, A. and Kamei, C. (2005) Hypnotic activities of chamomile and passifl ora extracts in sleep-disturbed rats. Biol. Pharm. Bull. 28, 808-810.   DOI
96 Meolie, A. L., Rosen, C., Kristo, D., Kohrman, M., Gooneratne, N., Aguillard, R. N., Fayle, R., Troell, R., Townsend, D., Claman, D., Hoban, T. and Mahowald, M. (2005) Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence. J. Clin. Sleep Med. 1, 173-187.
97 Monti, J. M. and Jantos, H. (2004) Effects of the 5-HT1A receptor ligands fl esinoxan and WAY 100635 given systemically or microinjected into the laterodorsal tegmental nucleus on REM sleep in the rat. Behav. Brain Res. 151, 159-166.   DOI
98 Nassiri-Asl, M., Shariati-Rad, S. and Zamansoltani, F. (2007) Anticonvulsant effects of aerial parts of Passifl ora incarnata extract in mice: involvement of benzodiazepine and opioid receptors. BMC Complement Altern. Med. 7, 26.   DOI
99 Naude, D. F., Stephanie Couchman, I. M. and Maharaj, A. (2010) Chronic primary insomnia: effi cacy of homeopathic simillimum. Homeopathy 99, 63-68.   DOI