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http://dx.doi.org/10.4062/biomolther.2011.19.2.201

A Comparative Study of the Anti-Platelet Effects of cis- and trans-Resveratrol  

Kim, Hwa (College of Pharmacy, Chonnam National University)
Oh, Seok-Jeong (College of Pharmacy, Chonnam National University)
Liu, Yingqiu (College of Pharmacy, Chonnam National University)
Lee, Moo-Yeol (College of Pharmacy, Chonnam National University)
Publication Information
Biomolecules & Therapeutics / v.19, no.2, 2011 , pp. 201-205 More about this Journal
Abstract
Although various biological activities of resveratrol have been extensively studied, most reports have focused on trans-resveratrol and little attention has been paid to the cis-isomer. In this study, the effect of cis-resveratrol on platelet activity was examined and compared with that of the trans-isomer. Treatment with cis-resveratrol resulted in inhibition of platelet aggregation induced by thrombin, collagen or ADP, which are representative aggregation-inducing agents, and the trans-isomer elicited the same effects. These effects were concentration-dependent in the range of 1-100 ${\mu}M$. However, the potency of the cis-isomer was much lower than that of the trans-isomer; the $IC_{50}$ values for the cis-isomer versus the trans-isomer were $31{\pm}12$ vs $151{\pm}3$, $161{\pm}3$ vs $91{\pm}4$, and $601{\pm}15$ vs $251{\pm}6\;{\mu}M$ for thrombin-, collagen- and ADP-induced aggregation, respectively. These results indicate that cis-resveratrol has a less potent anti-platelet activity, compared with the trans-isomer, and raise the possibility that the biological activities of the cis-isomer may be different from those of the trans-isomer. It will be necessary to evaluate the activity of cis-resveratrol independently of the trans-isomer.
Keywords
Resveratrol; Platelets; Anti-platelet effect;
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