Neuroprotective Effects of Carpinus tschonoskii MAX on 6-Hydroxydopamine-Induced Death of PC12 Cells |
Kim, Min-Kyoung
(Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Jeju National University)
Kim, Sang-Cheol (Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Jeju National University) Kang, Jung-Il (Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Jeju National University) Boo, Hye-Jin (Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Jeju National University) Hyun, Jin-Won (Department of Biochemistry, School of Medicine, Institute of Medical Sciences, Jeju National University) Koh, Young-Sang (Department of Microbiology, School of Medicine, Institute of Medical Sciences, Jeju National University) Park, Deok-Bae (Department of Histology, School of Medicine, Institute of Medical Sciences, Jeju National University) Yoo, Eun-Sook (Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Jeju National University) Kang, Ji-Hoon (Department of Neurology, School of Medicine, Institute of Medical Sciences, Jeju National University) Kang, Hee-Kyoung (Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Jeju National University) |
1 | Smith, P. D., Mount, M. P., Shree, R., Callaghan, S., Slack, R. S., Anisman H., Vincent, I., Wang, X., Mao, Z. and Park, D. S. (2006). Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2. J. Neurosci. 11, 440-447. |
2 | Subramaniam, S. and Unsicker, K. (2006). Extracellular signalregulated kinase as an inducer of non-apoptotic neuronal death. Neuroscience 138, 1055-1065. DOI |
3 | Tang, X., Wang, X., Gong, X., Tong, M., Park, D., Xia, Z. and Mao, Z. (2005). Cyclin-dependent kinase 5 mediates neurotoxin- induced degradation of the transcription factor myocyte enhancer factor 2. J. Neurosci. 25, 4823-4834. DOI |
4 | Veeranna, G. J., Shetty, K. T., Takahashi, M., Grant, P. and Pant, H. C. (2000). Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain. Mol. Brain Res. 76, 229-236. DOI |
5 | Zhang, R., Kang, K. A., Piao, M. J., Park, J. W., Shin, T., Yoo, B. S., Yang, Y. T. and Hyun, J. W. (2007). Cytoprotective Activity of Carpinus tschonoskii against Induced Oxidative Stress. Natural Product Sciences 13, 118-122. |
6 | Przedborski, S. and Ischiropoulos, H. (2005). Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease. Antioxid. Redox Signal 7, 685-693. DOI |
7 | Rosenkranz, A. R., Schmaldienst, S., Stuhlmeier, K. M., Chen, W., Knapp, W. and Zlabinger, G. J. (1992). A microplate assay for the detection of oxidative products using 2',7'- dichlorofluorescin-diacetate. J. Immunol. Methods. 25, 39-45. |
8 | Saito, Y., Nishio, K., Ogawa, Y., Kinumi, T., Yoshida, Y., Masuo, Y. and Niki, E. (2007). Molecular mechanisms of 6-hydroxydopamine- induced cytotoxicity in PC12 cells: involvement of hydrogen peroxide-dependent and -independent action. Free Radic. Biol. Med. 42, 675-685. DOI |
9 | Sako, K., Fukuhara, S., Minami, T., Hamakubo, T., Song, H., Kodama, T., Fukamizu A., Gutkind, J. S., Koh, G. Y. and Mochizuki, N. (2009). Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/ AKT-dependent activation of myocyte enhancer factor 2. J. Biol. Chem. 284, 5592-5601. DOI |
10 | Scudiero, D. A., Shoemaker, R. H., Paull, K. D., Monks, A., Tierney, S., Nofziger, T. H., Currens, M. J., Seniff, D. and Boyd, M. R. (1988). Evaluation of a soluble tetrazolium/ formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res. 48, 4827-4833. |
11 | Shim, J. S., Kim, H. G., Ju, M. S., Choi, J. G., Jeong, S. Y. and Oh, M. S. (2009). Effects of the hook of Uncaria rhynchophylla on neurotoxicity in the 6-hydroxydopamine model of Parkinson's disease. J. Ethnopharmacol. 126, 361-365. DOI |
12 | Shimoke, K. and Chiba, H. (2001). Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease. J. Neurosci. Res. 63, 402-409. DOI |
13 | Liu, L., Cavanaugh, J. E., Wang, Y., Sakagami, H., Mao, Z. and Xia, Z. (2003). ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons. Proc. Natl. Acad. Sci. USA. 100, 8532-8537. DOI |
14 | Mercer, L. D., Kelly, B. L., Horne, M. K., Beart, P. M. (2005). Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures. Biochem. Pharmacol. 69, 339-345. DOI |
15 | Lotharius, J., Dugan, L. L. and O’Malley, K. L. (1999). Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J. Neurosci. 19, 1284-1293. DOI |
16 | Mao, Z., Bonni, A., Xia, F., Nadal-Vicens, M. and Greenberg, M. E. (1999). Neuronal activity-dependent cell survival mediated by transcription factor MEF2. Science 286, 785-790. DOI |
17 | Mao, Z. and Wiedmann, M. (1999). Calcineurin enhances MEF2 DNA binding activity in calcium-dependent survival of cerebellar granule neurons. J. Biol. Chem. 274, 31102-31107. DOI |
18 | Nie, G., Jin, C., Cao, Y., Shen, S. and Zhao, B. (2002). Distinct effects of tea catechins on 6-hydroxydopamine-induced apoptosis in PC12 cells. Arch. Biochem. Biophys. 397, 84-90. DOI |
19 | Okamoto, S., Krainc, D. and Sherman, K. (2000). Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation. Proc. Natl. Acad. Sci. USA. 97, 7561-7566 DOI |
20 | Perumal, A. S., Tordzro, W. K., Katz, M., Jackson-Lewis, V., Cooper, T. B., Fahn, S. and Cadet, J. L. (1989). Regional effects of 6-hydroxydopamine on free radical scavengers in the rat brain. Brain Res. 504, 139-141. DOI |
21 | Greggio, E. and Singleton, A. (2007). Kinase signaling pathways as potential targets in the treatment of Parkinson's disease. Expert Rev. Proteomics. 4, 783-792. DOI |
22 | Jiang, Z. and Yu, P. H. (2005). Involvement of extracellular signal-regulated kinases 1/2 and (phosphoinositide 3-kinase)/ Akt signal pathways in acquired resistance against neurotoxin of 6-hydroxydopamine in SH-SY5Y cells following cellcell interaction with astrocytes. Neuroscience 133, 405-411. DOI |
23 | Heikkila, R. and Cohen, G. (1972). Inhibition of biogenic amine uptake by hydrogen peroxide: mechanism for toxic effects of 6-hydroxydopamine. Science 172, 1257-1258. |
24 | Jenner, P. and Olanow, C. W. (1996). Oxidative stress and the pathogenesis of Parkinson's disease. Neurology 47, S161-170. DOI ScienceOn |
25 | Jeon, J. I., Chang, C. S., Chen, Z. D. and Park, T. Y. (2007). Systematic aspects of foliar flavonoids in subsect. Carpinus (Carpinus, Betulaceae). Biochem. Syst. Ecol. 35, 606-613. DOI |
26 | Kim, M. K., Kim, S. C., Kang, J. I., Hyun, J. H., Boo, H. J., Eun, S. Y., Park, D. B., Yoo, E. S., Kang, H. K. and Kang, J. H. 6-Hydroxydopamine-induced death of PC12 cells is mediated by MEF2D down-regulation. Neurochem. Res. In revision. |
27 | Kulich, S. M., Horbinski, C., Patel, M. and Chu, C. T. (2007). 6-Hydroxydopamine induces mitochondrial ERK activation. Free Radic. Biol. Med. 43, 372-383. DOI |
28 | Kumar, R., Agarwal, M. L. and Seth, P. K. (1995). Free radicalgenerated neurotoxicity of 6-hydroxydopamine. J. Neurochem. 64, 1703-1707. DOI |
29 | Li, M., Linseman, D. A., Allen, M. P., Meintzer, M. K., Wang, X., Laessig, T., Wierman, M. E. and Heidenreich, K. A. (2001). Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons. J. Neurosci. 21, 6544-6552. DOI |
30 | Blum, D., Torch, S., Lambeng, N., Nissou, M., Benabid, A. L., Sadoul, R. and Verna J. M. (2001). Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson’s disease. Pro. Neurobiol. 65, 135-172. DOI |
31 | Bournival, J., Quessy, P. and Martinoli, M. G. (2009). Protective effects of resveratrol and quercetin against MPP+ -induced oxidative stress act by modulating markers of apoptotic death in dopaminergic neurons. Cell Mol. Neurobiol. 29, 1169-1180. DOI ScienceOn |
32 | Bove, J., Prou, D., Perier, C. and Przedborski, S. (2005). Toxininduced models of Parkinson's disease. NeuroRx. 2, 484-494. DOI |
33 | Brunet, A., Datta, S. R. and Greenberg, M. E. (2001). Transcriptiondependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr. Opin. Neurobiol. 11, 297-305. DOI |
34 | Chang, C. S. and Jeon, J. I. (2004). Foliar flavonoids of Carpinus, sect. Distegocarpus in eastern Asia. Biochem. Syst. Ecol. 32, 35-44. DOI |
35 | Choi, W. S., Yoon, S. Y., Oh, T. H., Choi, E. J., O'Malley, K. L. and Oh, Y. J. (1999). Two distinct mechanisms are involved in 6-hydroxydopamine- and MPP+-induced dopaminergic cell death: role of caspases, ROS and JNK. J. Neurosci. Res. 57, 86-94. DOI |
36 | Chong, Z. Z., Li, F. and Maiese, K. (2005). Activating Akt and the brain’s resources to drive cellular survival and prevent inflammatory injury. Histol. Histopathol. 20, 299-315. |
37 | Decker, D. E., Althaus, J. S., Buxser, S. E., VonVoigtlander, P. F. and Ruppel, P. L. (1993). Competitive irreversible inhibition of dopamine uptake by 6-hydroxydopamine. Res. Commun. Chem. Pathol. Pharmacol. 79,195-208. |
38 | Black, B. L. and Olson, E. N. (1998). Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annu. Rev. Cell Dev. Biol. 14, 167-196. DOI |
39 | Gong, X., Tang, X., Wiedmann, M., Wang, X., Peng, J., Zheng, D., Blair, L. A., Marshall, J. and Mao, Z. (2003). Cdk5- mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. Neuron 38, 33-46. DOI |
40 | Abad, F., Maroto, R., Lopez, M. G., Sánchez-García, P. and García, A. G. (1995). Pharmacological protection against the cytotoxicity of 6-hydroxydopamine and in chromaffin cells. Eur. J. Pharmacol. 293, 55-64. DOI ScienceOn |