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http://dx.doi.org/10.4062/biomolther.2010.18.3.321

Anti-Inflammatory Activity of Constituents Isolated from Ulmus davidiana var. japonica  

Zheng, Ming Shan (College of Pharmacy, Yeungnam University)
Yang, Ju-Hye (College of Pharmacy, Yeungnam University)
Li, Ying (College of Pharmacy, Yeungnam University)
Li, Xian (College of Pharmacy, Yeungnam University)
Chang, Hyeun-Wook (College of Pharmacy, Yeungnam University)
Son, Jong-Keun (College of Pharmacy, Yeungnam University)
Publication Information
Biomolecules & Therapeutics / v.18, no.3, 2010 , pp. 321-328 More about this Journal
Abstract
Twenty six compounds (1-26) were isolated from the root barks of Ulmus davidiana var. japonica. The anti-inflammatory activity of the isolated compounds were evaluated agai nst the generation of inflammatory chemical mediators in bone marrow-derived mast cells. Among them, compounds 10, 11, 13, 15 and 19 inhibited not only cyclooxygenase-2 dependent prostaglandin $D_2$ generation but also 5-lipoxygenase dependent leukotrien $C_4$ generation in a concentration-dependent manner. In addition, compounds 11, 12, 13, 15 and 19 also inhibited $\beta$-hexosaminidase release, a marker of mast cell degranulation reaction, from bone marrow-derived mast cell. These results suggest that the anti-inflammatory activity of U. davidiana might in part occur by both the inhibition of eicosanoid generations and the degranulation reaction of mast cells.
Keywords
Ulmus davidiana var. japonica; Bone marrow-derived mast cells; Cyclooxygenase-2, 5-Lipoxygenase; $\beta$-hexosaminidase; Anti-inflammatory activity;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By Web Of Science : 3  (Related Records In Web of Science)
Times Cited By SCOPUS : 2
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