Interleukin-4, Oxidative Stress, Vascular Inflammation and Atherosclerosis |
Lee, Yong-Woo
(Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University (Virginia Tech))
Kim, Paul H. (Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University (Virginia Tech)) Lee, Won-Hee (School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University (Virginia Tech)) Hirani, Anjali A. (School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University (Virginia Tech)) |
1 | Barks, J. L., McQuillan, J. J. and Iademarco, F. (1997). and IL-4 synergistically increase vascular cell adhesion molecule-1 expression in cultured vascular smooth muscle cells. J. Immunol. 159, 4532-4538. |
2 | Basta, G., Lazzerini, G., Del Turco, S., Ratto, G. M., Schmidt, A. M. and De Caterina, R. (2005). At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesion molecule-1 induction by advanced glycation end products. Arterioscler. Thromb. Vasc. Biol. 25, 1401-1407. DOI |
3 | Boring, L., Gosling, J., Cleary, M. and Charo, I. F. (1998). Decreased lesion formation in mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394, 894-897. DOI |
4 | Bouloumie, A., Marumo, T., Lafontan, M. and Busse, R. (1999). Leptin induces oxidative stress in human endothelial cells. FASEB J. 13, 1231-1238. DOI |
5 | Brandes, R. P. (2003). A radical adventure: The quest for specific functions and inhibitors of vascular NADPH oxidase. Circ. Res. 92, 583-585. DOI |
6 | Braunersreuther, V., Mach, F. and Steffens, S. (2007). The specific role of chemokines in atherosclerosis. Thromb. Haemost. 97, 714-721. |
7 | Buono, C., Come, C. E., Stavrakis, G., Maguire, G. F., Connelly, P. W. and Lichtman, A. H. (2003). Influence of on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse. Arterioscler. Thromb. Vasc. Biol. 23, 454-460. DOI |
8 | Bursill, C. A., Channon, K. M. and Greaves, D. R. (2004). The role of chemokines in atherosclerosis: recent evidence from experimental models and population genetics. Curr. Opin. Lipidol. 15, 145-149. DOI |
9 | Chen, C. C. and Manning, A. M. (1996). , IL-10 and IL-4 differentially modulate the cytokine-induced expression of IL-6 and IL-8 in human endothelial cells. Cytokine 8, 58-65. DOI ScienceOn |
10 | Clark, L. T. (2002). Vascular inflammation as a therapeutic target for prevention of cardiovascular disease. Curr. Atheroscler. Rep. 4, 77-81. |
11 | Colotta, F., Sironi, M., Borre, A., Luini, W., Maddalena, F. and Mantovani, A. (1992). Interleukin 4 amplifies monocyte chemoattractant protein and interleukin 6 production by endothelial cells. Cytokine 4, 24-28. DOI |
12 | Corda, S., Laplace, C., Vicaut, E. and Duranteau, J. (2001). Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis is mediated by ceramide. Am. J. Respir. Cell Mol. Biol. 24, 762-768. |
13 | Cybulsky, M. and Gimbrone, M. (1991). Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251, 788-791. DOI |
14 | Blease, K., Seybold, J., Adcock, I. M., Hellewell, P. G. and Burke-Gaffney, A. (1998). Interleukin-4 and lipopolysaccharide synergize to induce vascular cell adhesion molecule-1 expression in human lung microvascular endothelial cells. Am. J. Respir. Cell Mol. Biol. 18, 620-630. DOI ScienceOn |
15 | Davies, M. J., Gordon, J. L., Gearing, A. J., Pigott, R., Woolf, N., Katz, D. and Kyriakopoulos, A. (1993). The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J. Pathol. 171, 223-229. DOI |
16 | Cesari, M., Penninx, B. W., Newman, A. B., Kritchevsky, S. B., Nicklas, B. J., Sutton-Tyrrell, K., Tracy, R. P., Rubin, S. M., Harris, T. B. and Pahor, M. (2003). Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study). Am. J. Cardiol. 92, 522-528. DOI |
17 | Elices, M., Osborn, L., Takada, Y., Crouse, C., Luhowskyj, S., Hemler, M. and Lobb, R. (1990). VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 60, 577-584. DOI |
18 | Galea, P., Lebranchu, Y., Thibault, G. and Bardos, P. (1992). Interleukin 4 and tumor necrosis factor induce different adhesion pathways in endothelial cells for the binding of peripheral blood lymphocytes. Scand. J. Immunol. 36, 575-585. DOI |
19 | Galea, P., Thibault, G., Lacord, M., Bardos, P. and Lebranchu Y. (1993). IL-4, but not tumor necrosis , increases endothelial cell adhesiveness for lymphocytes by activating a cAMP-dependent pathway. J. Immunol. 151, 588-596. |
20 | Gosling, J., Slaymaker, S., Gu, L., Tseng, S., Zlot, C. H., Young, S. G., Rollins, B. J. and Charo, I. F. (1999). MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B. J. Clin. Invest. 103, 773-778. DOI |
21 | Gu, L., Okada, Y., Clinton, S. K., Gerard, C., Sukhova, G. K., Libby, P. and Rollins, B. J. (1998). Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol. Cell 2, 275-281. DOI |
22 | Gu, L., Tseng, S. C. and Rollins, B. J. (1999). Monocyte chemoattractant protein-1. Chem. Immunol. 72, 7-29. DOI |
23 | Guzik, T. J. and Griendling, K. K. (2009). NADPH oxidases: Molecular understanding finally reaching the clinical level? Antioxid. Redox. Signal 11, 2365-2370. DOI |
24 | Hong, H. Y., Lee, H. Y., Kwak, W., Yoo, J., Na, M. H., So, I. S., Kwon, T. H., Park, H. S., Huh, S., Oh, G. T., Kwon, I. C., Kim, I. S. and Lee, B. H. (2008). Phage display selection of peptides that home to atherosclerotic plaques: IL-4 receptor as a candidate target in atherosclerosis. J. Cell. Mol. Med. 12, 2003-2014. DOI ScienceOn |
25 | Guzik, T. J., Sadowski, J., Guzik, B., Jopek, A., Kapelak, B., Przybylowski, P., Wierzbicki, K., Korbut, R., Harrison, D. G. and Channon, K. M. (2006). Coronary artery superoxide production and nox isoform expression in human coronary artery disease. Arterioscler. Thromb. Vasc. Biol. 26, 333-339. DOI |
26 | Heitzer, T., Schlinzig, T., Krohn, K., Meinertz, T. and Munzel, T. (2001). Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104, 2673-2678. DOI |
27 | Davenport, P. and Tipping, P. G. (2003). The role of interleukin- 4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice. Am. J. Pathol. 163, 1117-1125. DOI ScienceOn |
28 | Huang, H., Lavoie-Lamoureux, A. and Lavoie, J. P. (2009). Cholinergic stimulation attenuates the IL-4 induced expression of E-selectin and vascular endothelial growth factor by equine pulmonary artery endothelial cells. Vet. Immunol. Immunopharmacol. 132, 116-121. DOI |
29 | Huang, H., Lavoie-Lamoureux, A., Moran, K. and Lavoie, J. P. (2007). IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 292, L1147-L1154. DOI |
30 | Huber, S. A., Sakkinen, P., Conze, D., Hardin, N. and Tracy, R. (1999). Interleukin-6 exacerbates early atherosclerosis in mice. Arterioscler. Thromb. Vasc. Biol. 19, 2364-2367. DOI ScienceOn |
31 | Goettsch, C., Goettsch, W., Arsov, A., Hofbauer, L. C., Bornstein, S. R. and Morawietz, H. (2009). Long-term cyclic strain downregulates endothelial Nox4. Antioxid. Redox. Signal 11, 2385-2397. DOI |
32 | Huo, Y., Hafezi-Moghadam, A. and Ley, K. (2000). Role of vascular cell adhesion molecule-1 and fibronectin connecting segment-1 in monocyte rolling and adhesion on early atherosclerotic lesions. Circ. Res. 87, 153-159. DOI ScienceOn |
33 | Huo, Y. and Ley, K. (2001). Adhesion molecules and atherogenesis. Acta. Physiol. Scand. 173, 35-43. DOI |
34 | Iiyama, K., Hajra, L., Iiyama, M., Li, H., DiChiara, M., Medoff, B. D. and Cybulsky, M. I. (1999). Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Circ. Res. 85, 199-207. DOI ScienceOn |
35 | King, V. L., Szilvassy, S. J. and Daugherty, A. (2002). Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/-mice. Arterioscler. Thromb. Vasc. Biol. 22, 456-461. DOI |
36 | Kirii, H., Niwa, T., Yamada, Y., Wada, H., Saito, K., Iwakura, Y., Asano, M., Moriwaki, H. and Seishima, M. (2003). Lack of decreases the severity of atherosclerosis in ApoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 23, 656-660. DOI |
37 | Kishikawa, H., Shimokama, T. and Watanabe, T. (1993). Localization of T lymphocytes and macrophages expressing IL-1, IL-2 receptor, IL-6 and TNF in human aortic intima: Role of cell mediated immunity in human atherogenesis. Virchows Arch. A. Pathol. Anat. Histopathol. 423, 433-442. DOI |
38 | Kishimoto, T. (2005). Interleukin-6: From basic science to medicine-40 years in immunology. Annu. Rev. Immunol. 23, 1-21. DOI |
39 | Lee, Y. W., Eum, S. Y., Nath, A. and Toborek, M. (2004a). Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells. Cardiovasc. Res. 63, 139-148. DOI |
40 | Lee, Y. W., Eum, S. Y., Chen, K. C., Hennig, B. and Toborek, M. (2004b). Gene expression profile in interleukin-4-stimulated human vascular endothelial cells. Mol. Med. 10, 19-27. DOI |
41 | Hennig, B. and Chow, C. K. (1988). Lipid peroxidation and endothelial cell injury: implication in atherosclerosis. Free Radical Biol. Med. 4, 99-106. DOI |
42 | Hennig, B., Toborek, M., McClain, C. J. and Diana, J. N. (1996). Nutritional implications in vascular endothelial cell metabolism. J. Am. Coll. Nutr. 15, 345-358. DOI |
43 | Lee, Y. W., Kühn, H., Hennig, B., Neish, A. S. and Toborek, M. (2001a). IL-4-induced oxidative stress upregulates VCAM-1 gene expression in human endothelial cells. J. Mol. Cell. Cardiol. 33, 83-94. DOI |
44 | Lee, Y. W., Kuhn, H., Hennig, B. and Toborek, M. (2000). IL-4 induces apoptosis of endothelial cells through the caspase-3-dependent pathway. FBES Lett. 485, 122-126. DOI |
45 | Lee, Y. W., Kuhn, H., Kaiser, S., Hennig, B., Daugherty, A. and Toborek, M. (2001b). Interleukin-4 induces transcription of the 15-lipoxygenase-I gene in human endothelial cells. J. Lipid Res. 42, 783-791. |
46 | Lee, Y. W., Lee, W. H. and Kim, P. H. (2010a). Oxidative mechanisms of IL-4-induced IL-6 expression in vascular endothelium. Cytokine 49, 73-79. DOI |
47 | Inoue, S., Egashira, K., Ni, W., Kitamoto, S., Usui, M., Otani, K., Ishibashi, M., Hiasa, K., Nishida, K. and Takeshita, A. (2002). Anti-monocyte chemoattractant protein-1 gene therapy limits progression and destabilization of established atherosclerosis in apolipoprotein E-knockout mice. Circulation 106, 2700-2706. DOI |
48 | Libby, P. and Galis, Z. S. (1995). Cytokines regulate genes involved in atherogenesis. Ann. N. Y. Acad. Sci. 748, 158-168. |
49 | Khan, B. V., Parthasarathy, S. S., Alexander, R. W. and Medford, R. M. (1995). Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells. J. Clin. Invest. 95, 1262-1270. DOI |
50 | Li, H., Cybulsky, M. I., Gimbrone, M. A. Jr. and Libby, P. (1993). An atherogenic diet rapidly induces VCAM-1, a cytokineregulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler. Thromb. 13, 197-204. DOI |
51 | Libby, P., Ridker, P. M. and Maseri, A. (2002). Inflammation and atherosclerosis. Circulation 105, 1135-1143. DOI |
52 | Lumsden, A. B., Chen, C., Hughes, J. D., Kelly, A. B., Hanson, S. R. and Harker, L. A. (1997). Anti-VLA-4 antibody reduces intimal hyperplasia in the endarterectomized carotid artery in nonhuman primates. J. Vasc. Surg. 26, 87-93. DOI |
53 | Lee, Y. W., Hennig, B. and Toborek, M. (2003). Redox-regulated mechanisms of IL-4-induced MCP-1 expression in human vascular endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 284, H185-H192. DOI |
54 | Lee, Y. W. and Hirani, A. A. (2006). Role of interleukin-4 in atherosclerosis. Arch. Pharm. Res. 29, 1-15. DOI |
55 | Lee, Y. W., Lee, W. H. and Kim, P. H. (2010b). Role of NADPH oxidase in interleukin-4-induced monocyte chemoattractant protein-1 expression in vascular endothelium. Inflamm. Res. In press [DOI: 10.1007/s00011-010-0187-3]. DOI |
56 | Paul, W. E. (1991). Interleukin-4: a prototypic immunoregulatory lymphokine. Blood 77, 1859-1870. |
57 | O’Brien, K. D., Allen, M. D., McDonald, T. O., Chait, A., Harlan, J. M., Fishbein, D., McCarty, J., Ferguson, M., Hudkins, K. and Benjamin, C. D. (1993). Vascular cell adhesion molecule- 1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis. J. Clin. Invest. 92, 945-951. DOI |
58 | Oguchi, S., Dimayuga, P., Zhu, J., Chyu, K. Y., Yano, J., Shah, P. K., Nilsson, J. and Cercek, B. (2000). Monoclonal antibody against vascular cell adhesion molecule-1 inhibits neointimal formation after periadventitial carotid artery injury in genetically hypercholesterolemic mice. Arterioscler. Thromb. Vasc. Biol. 20, 1729-1736. DOI ScienceOn |
59 | Park, K. W., Baik, H. H. and Jin, B. K. (2008). Interleukin- 4-induced oxidative stress via microglial NADPH oxidase contributes to the death of hippocampal neurons in vivo. Curr. Aging Sci. 1, 192-201. DOI ScienceOn |
60 | Price, D. T. and Loscalzo, J. (1999). Cellular adhesion molecules and atherogenesis. Am. J. Med. 107, 85-97. |
61 | Reape, T. J. and Groot, P. H. (1999). Chemokines and atherosclerosis. Atherosclerosis 147, 213 -225. DOI |
62 | Martinovic, I., Abegunewardene, N., Seul, M., Vosseler, M., Horstick, G., Buerke, M., Darius, H. and Lindemann, S. (2005). Elevated monocyte chemoattractant protein-1 serum levels in patients at risk for coronary artery disease. Circ. J. 69, 1484-1489. DOI |
63 | Marx, N. and Grant, P. J. (2007). Endothelial dysfunction and cardiovascular disease - the lull before the storm. Diab. Vasc. Dis. Res. 4, 82-83. DOI |
64 | Masinovsky, B., Urdal, D. and Gallatin, W. M. (1990). IL-4 acts synergistically with to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1. J. Immunol. 145, 2886-2895. |
65 | Ohta, H., Wada, H., Niwa, T., Kirii, H., Iwamoto, N., Fujii, H., Saito, K., Sekikawa, K. and Seisima, M. (2005). Disruption of tumor necrosis gene diminishes the development of atherosclerosis in ApoE-deficient mice. Atherosclerosis 180, 11-17. DOI |
66 | Nakashima, Y., Raines, E. W., Plump, A. S., Breslow, J. L. and Ross, R. (1998). Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse. Arterioscler. Thromb. Vasc. Biol. 18, 842-851. DOI ScienceOn |
67 | Nelken, N. A., Coughlin, S. R., Gordon, D. and Wilcox, J. N. (1991). Monocyte chemoattractant protein-1 in human atheromatous plaques. J. Clin. Invest. 88, 1121-1127. DOI |
68 | Ni, W., Egashira, K., Kitamoto, S., Kataoka, C., Koyanagi, M., Inoue, S., Imaizumi, K., Akiyama, C., Nishida, K. I. and Takeshita, A. (2001). New anti-monocyte chemoattractant protein-1 gene therapy attenuates atherosclerosis in apolipoprotein E-knockout mice. Circulation 103, 2096-2101. DOI ScienceOn |
69 | Oltman, C. L., Kane, N. L., Miller, F. J. Jr., Spector, A. A., Weintraub, N. L. and Dellsperger, K. C. (2003). Reactive oxygen species mediate arachidonic acid-induced dilation in porcine coronary microvessels. Am. J. Physiol. Heart Circ. Physiol. 285, H2309-H2315. DOI |
70 | Osborn, L., Hession, C., Tizard, R., Vassallo, C., Luhowskyj, S., Chi-Rosso, G. and Lobb, R. (1989). Direct expression cloning of vascular cell adhesion molecule 1, a cytokineinduced endothelial protein that binds to lymphocytes. Cell 59, 1203-1211. DOI |
71 | Paleolog, E. M., Aluri, G. R. and Feldmann, M. (1992). Contrasting effects of interferon and interleukin 4 on responses of human vascular endothelial cells to tumor necrosis factor . Cytokine 4, 470-478. DOI |
72 | Rollins, B. J. (1997). Chemokines. Blood 90, 909-928. |
73 | Ridker, P. M., Hennekens, C. H., Buring, J. E. and Rifai, N. (2000a). C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N. Engl. J. Med. 342, 836-843. DOI |
74 | Ridker, P. M., Rifai, N., Stampfer, M. J. and Hennekens, C. H. (2000b). Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 101, 1767-1772. DOI ScienceOn |
75 | Rocken, M., Racke, M. and Shevach, E. M. (1996). IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease. Immunol. Today 17, 225-231. DOI |
76 | Rollins, B. J. and Pober, J. S. (1991). Interleukin-4 induces the synthesis and secretion of MCP-1/JE by human endothelial cells. Am. J. Pathol. 138, 1315-1319. |
77 | Ross, R. (1993). The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362, 801-809. DOI ScienceOn |
78 | Ross, R. (1999). Atherosclerosis is an inflammatory disease. Am. Heart J. 138, S419-S420. DOI |
79 | Sakai, A., Kume, N., Nishi, E., Tanoue, K., Miyasaka, M. and Kita, T. (1997). P-selectin and vascular cell adhesion molecule-1 are focally expressed in aortas of hypercholesterolemic rabbits before intimal accumulation of macrophages and T lymphocytes. Arterioscler. Thromb. Vasc. Biol. 17, 310-316. DOI ScienceOn |
80 | Schleimer, R. P., Sterbinsky, S. A., Kaiser, J., Bickel, C. A., Klunk, D. A., Tomioka, K., Newman, W., Luscinskas, F. W., Gimbrone, M. A. Jr. and McIntyre, B. W. (1992). IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1. J. Immunol. 148, 1086-1092. |
81 | Simmons, P. J., Masinovsky, B., Longenecker, B. M., Berenson, R., Torok-Storb, B. and Gallatin, W. M. (1992). Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells. Blood 80, 388-395. |
82 | Schuett, H., Luchtefeld, M., Grothusen, C., Grote, K. and Schieffer, B. (2009). How much is too much? Interleukin-6 and its signaling in atherosclerosis. Thromb. Haemost. 102, 215-222. |
83 | Sheikine, Y. A. and Hansson, G. K. (2006). Chemokines as potential therapeutic targets in atherosclerosis. Curr. Drug Targets 7, 13-27. DOI |
84 | Shishehbor, M. H. and Bhatt, D. L. (2004). Inflammation and atherosclerosis. Curr. Atheroscler. Rep. 6, 131-139. DOI |
85 | Sorescu, D., Weiss, D., Lassegue, B., Clempus, R. E., Szocs, K., Sorescu, G. P., Valppu, L., Quinn, M. T., Lambeth, J. D., Vega, J. D., Taylor, W. R. and Griendling, K. K. (2002). Superoxide production and expression of Nox family proteins in human atherosclerosis. Circulation 105, 1429-1435. DOI |
86 | Srinivasan, S., Hatley, M. E., Reilly, K. B., Danziger, E. C. and Hedrick, C. C. (2004). Modulation of expression and inflammatory interleukin-6 production by chronic glucose increases monocyte/endothelial adhesion. Arterioscler. Thromb. Vasc. Biol. 24, 851-857. DOI |
87 | Strieter, R. M., Wiggins, R., Phan, S. H., Wharram, B. L., Showell, H. J., Remick, D. G., Chensue, S. W. and Kunkel, S. L. (1989). Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cells. Biochem. Biophys. Res. Commun. 162, 694-700. DOI |
88 | Sukovich, D. A., Kauser, K., Shirley, F. D., DelVecchio, V., Halks-Miller, M. and Rubanyi, G. M. (1998). Expression of interleukin-6 in atherosclerotic lesions of male apoEknockout mice. Arterioscler. Thromb. Vasc. Biol. 18, 1498-1505. DOI ScienceOn |
89 | Seino, Y., Ikeda, U., Ikeda, M., Yamamoto, K., Misawa, Y., Hasegawa, T., Kano, S. and Shimada, K. (1994). Interleukin 6 gene transcripts are expressed in human atherosclerotic lesions. Cytokine 6, 87-91. DOI |
90 | Yla-Herttuala, S. (1992). Gene expression in atherosclerotic lesions. Hertz 17, 270-276. |
91 | Taubman, M. B., Rollins, B. J., Poon, M., Marmur, J., Green, R. S., Berk, B. C. and Nadal-Ginard, B. (1992). JE mRNA accumulates rapidly in aortic injury and in platelet-derived growth factor-stimulated vascular smooth muscle cells. Circ. Res. 70, 314-325. DOI ScienceOn |
92 | Tedgui, A. and Mallat, Z. (2006). Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol. Rev. 86, 515-581. DOI |
93 | Thomas, S. R., Witting, P. K. and Drummond, G. R. (2008). Redox control of endothelial function and dysfunction: Molecular mechanisms and therapeutic opportunities. Antioxid. Redox Signal. 10, 1713-1765. DOI |
94 | Toborek, M. and Kaiser, S. (1999). Endothelial cell functions. Relationship to atherogenesis. Basic Res. Cardiol. 94, 295-314. DOI |
95 | Walch, L., Massade, L., Dufilho, M., Brunet, A. and Rendu, F. (2006). Pro-atherogenic effect of interleukin-4 in endothelial cells: modulation of oxidative stress, nitric oxide and monocyte chemoattractant protein-1 expression. Atherosclerosis 187, 285-291. DOI |
96 | Weissenbach, M., Clahsen, T., Weber, C., Spitzer, D., Wirth, D., Vestweber, D., Heinrich, P. C. and Schaper, F. (2004). Interleukin-6 is a direct mediator of T cell migration. Eur. J. Immunol. 34, 2895-2906. DOI |
97 | Wung, B. S., Cheng, J. J., Hsieh, H. J., Shyy, Y. J. and Wang, D. L. (1997). Cyclic strain-induced monocyte chemotactic protein-1 gene expression in endothelial cells involves reactive oxygen species activation of activator protein 1. Circ. Res. 81, 1-7. DOI ScienceOn |
98 | Aiello, R. J., Bourassa, P. K., Lindsey, S., Weng, W., Natoli, E., Rollins, B. J. and Milos, P. M. (1999). Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 19, 1518-1525. DOI ScienceOn |
99 | Takeya, M., Yoshimura, T., Leonard, E. J. and Takahashi, K. (1993). Detection of monocyte chemoattractant protein-1 in human atherosclerotic lesions by an anti-monocyte chemoattractant protein-1 monoclonal antibody. Hum. Pathol. 24, 534-539. DOI |
100 | Yla-Herttuala, S., Lipton, B. A., Rosenfeld, M. E., Sarkioja, T., Yoshimura, T., Leonard, E. J., Witztum, J. L. and Steinberg, D. (1991). Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. Proc. Natl. Acad. Sci. USA 88, 5252-5256. DOI |
101 | American Heart Association Statistics Committee and Stroke Statistics Subcommittee. (2010). Heart disease and stroke statistics - 2010 update. Circulation 121, e1-e170. DOI |
102 | Bedard, K. and Krause, K. (2007). The NOX family of ROSgenerating NADPH oxidase: Physiology and Pathophysiology. Physiol. Rev. 87, 245-313. DOI |
103 | Berliner, J. A., Navab, M., Fogelman, A. M., Frank, J. S., Demer, L. L., Edwards, P. A., Watson, A. D. and Lusis, A. J. (1995). Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics. Circulation 91, 2488-2496. DOI ScienceOn |
104 | Blankenberg, S., Barbaux, S. and Tiret, L. (2003). Adhesion molecules and atherosclerosis. Atherosclerosis 170, 191-203. DOI |