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http://dx.doi.org/10.4062/biomolther.2009.17.4.446

Immunotoxicological Investigation of 1-furan-2-yl-3-pyridin-2-yl-propenone in Female BALB/c Mice  

Jeon, Tae-Won (College of Pharmacy, Yeungnam University)
Kim, Chun-Hwa (College of Pharmacy, Yeungnam University)
Lee, Sang-Kyu (College of Pharmacy, Yeungnam University)
Ko, Gyu-Sub (College of Pharmacy, Yeungnam University)
Yoo, Jin-Woo (College of Pharmacy, Yeungnam University)
Ha, Hyun-Woo (College of Pharmacy, Yeungnam University)
Kang, Won-Ku (College of Pharmacy, Catholic University of Daegu)
Jeong, Hye-Gwang (Chungnam National University)
Kang, Mi-Jeong (College of Pharmacy, Yeungnam University)
Lee, Eung-Seok (College of Pharmacy, Yeungnam University)
Jeong, Tae-Cheon (College of Pharmacy, Yeungnam University)
Publication Information
Biomolecules & Therapeutics / v.17, no.4, 2009 , pp. 446-454 More about this Journal
Abstract
1-Furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) has recently been synthesized and characterized to have an anti-inflammatory activity through the inhibition of the production of nitric oxide and tumor necrosis factor-$\alpha$. In the present study, adverse effects of FPP-3 on immune functions were determined in female BALB/c mice. When mice were administered orally with FPP-3 at 125, 250 or 500 mg/kg for 7 consecutive days, FPP-3 suppressed the number of antibody-forming cells and reduced thymus weight at 500 mg/kg. In addition, FPP-3 administered mice exhibited reduced splenic cellularity and numbers of splenocyte subsets, such as $CD3^+$ cells, $CD3^+CD4^+$ cells, $CD3^+CD8^+$ cells and macrophages. IL-4 mRNA expression was significantly suppressed by FPP-3 treatment. Moreover, the number of $CD4^+IL-4^+$ cells was reduced following the treatment of mice with 500 mg/kg of FPP-3. These results suggested that FPP-3 at 500 mg/kg might be immunotoxic, and that FPP-3-induced immunotoxicity might be mediated, at least in part, through the inhibition of cytokine production, such as IL-4.
Keywords
1-Furan-2-yl-3-pyridin-2-yl-propenone; Immunotoxicity; Antibody-forming cells; Cytokines;
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1 Davila, D. R., Davis, D. P., Campbell, K., Cambier, J. C., Zigmond, L. A. and Burchiel, S. W. (1995). Role of alterations in Ca2＋-associated signaling pathways in the immunotoxicity of polycyclic aromatic hydrocarbons. J. Toxicol. Environ. Health 45, 101-126.   DOI   ScienceOn
2 Dean, J. H., Ward, E. C., Murray, M. J., Lauer, L. D. and House, R. V. (1985). Mechanisms of dimethylbenzanthraceneinduced immunotoxicity. Clin. Physiol. Biochem. 3, 98-110.
3 Fearon, D. T. and Locksley, R. M. (1996). The instructive role of innate immunity in the acquired immune response. Science 272, 50-53.   DOI   ScienceOn
4 Seder, R. A., Paul, W. E., Davis, M. M. and de St Groth, B. F. (1992). The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of $CD4^+$ T cells from T cell receptor transgenic mice. J. Exp. Med. 176, 1091-1098.   DOI   ScienceOn
5 Whitehurst, C. E. and Geppert, T. D. (1996). MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells. J. Immunol. 156, 1020-1029.
6 Luster, M. I., Portier, C., Pait, D. G., White, K. L. Jr., Gennings, C., Munson, A. E. and Rosenthal, G. J. (1992). Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests. Fundam. Appl. Toxicol. 18, 200-210.   DOI   ScienceOn
7 Kremer, J., Gleichmann, E. and Esser, C. (1994). Thymic stroma exposed to arylhydrocarbon receptor-binding xenobiotics fails to support proliferation of early thymocytes but induces differentiation. J. Immunol. 153, 2778-2786.
8 Luster, M. I., Portier, C., Pait, D. G., Rosenthal, G. J., Germolec, D. R., Corsini, E., Blaylock, B. L., Pollock, P., Kouchi, Y., Craig, W., White, K. L. Jr., Munson, A. E. and Comment, C. E. (1993). Risk assessment in immunotoxicology. II. Relationships between immune and host resistance tests. Fundam. Appl. Toxicol. 21, 71-82.   DOI   ScienceOn
9 Mullen, A. C., High, F. A., Hutchins, A. S., Lee, H. W., Villarino, A. V., Livingston, D. M., Kung, A. L., Cereb, N., Yao, T. P., Yang, S. Y. and Reiner, S. L. (2001). Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292, 1907-1910.   DOI   ScienceOn
10 Jeon, T. W., Jin, C. H., Lee, S. K., Lee, D. W., Hyun, S. H., Kim, G. H., Jun, I. H., Lee, B. M., Yum, Y. N., Kim, J. K., Kim, O. H. and Jeong, T. C. (2005). In vivo and in vitro immunosuppressive effects of benzo[k]fluoranthene in female BALB/c mice. J. Toxicol. Environ. Health A. 68, 2033-2050.   DOI   ScienceOn
11 Swain, S. L., Bradley, L. M., Croft, M., Tonkonogy, S., Atkins, G., Weinberg, A. D., Duncan, D. D., Hedrick, S. M., Dutton, R. W. and Huston, G. (1991). Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol. Rev. 123, 115-144.   DOI
12 Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A. and Coffman, R. L. (1986). Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2357.
13 Mosmann, T. R. and Sad, S. (1996). The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17, 138-146.   DOI   ScienceOn
14 Myers, M. J., Blanton, R. H. and Bick, P. H. (1988). Inhibition of IL-2 responsiveness following exposure to benzo(a)pyren is due to alterations in accessory cell function. Int. J. Immunopharmacol. 10, 177-186.   DOI   ScienceOn
15 Jahng, Y., Zhao, L. X., Moon, Y. S., Basnet, A., Kim, E. K., Chang, H. W., Ju, H. K., Jeong, T. C. and Lee, E. S. (2004). Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities. Bioorg. Med. Chem. Lett. 14, 2559-2562.   DOI   ScienceOn
16 Pallardy, M., Mishal, Z., Lebrec, H. and Bohuon, C. (1992). Immune modification due to chemical interference with transmembrane signaling: application to polycyclic aromatic hydrocarbons. Int. J. Immunopharmacol. 14, 377-382.   DOI   ScienceOn
17 Jeon, T. W., Kim, C. H., Lee, S. K., Shin, S., Choi, J. H., Kang, W., Kim, S. H., Kang, M. J., Lee, E. S. and Jeong, T. C. (2009). Hepatotoxic effects of 1-furan-2-yl-3-pyridin-2-ylpropenone, an anti-inflammatory agent, in male ICR mice. Biomol. Ther. 17, 318-324.   과학기술학회마을   DOI   ScienceOn
18 Kaminski, N. E., Barnes, D., Jordan, S. D. and Holsapple, M. P. (1990). The role of metabolism in carbon tetrachloridemediated immunosuppression. In vivo studies. Toxicol. Appl. Pharmacol. 102, 9-20.   DOI   ScienceOn
19 Luster, M. I., Munson, A. E., Thomas, P. T., Holsapple, M. P., Fenters, J. D., White, K. L. Jr., Lauer, L. D., Germolec, D. R., Rosenthal, G. J. and Dean, J. H. (1988). Development of a testing battery to assess chemical-induced immunotoxicity: National Toxicology Program's guidelines for immunotoxicity evaluation in mice. Fundam. Appl. Toxicol. 10, 2-19.   DOI   ScienceOn
20 Okey, A. B., Dube, A. W. and Vella, L. M. (1984). Binding of benzo(a)pyren and dibenz(a,h)anthracene to the Ah receptor in mouse and rat hepatic cytosols. Cancer Res. 44, 1426-1432.
21 Shi, L., Nishioka, W. K., Th'ng, J., Bradbury, E. M., Litchfield, D. W. and Greenberg, A. H. (1994). Premature p34cdc2 activation required for apoptosis. Science 263, 1143-1145.   DOI
22 Ginsberg, G. L., Atherholt, T. B. and Butler, G. H. (1989). Benzo[a]pyrene-induced immunotoxicity: comparison to DNA adduct formation in vivo, in cultured splenocytes, and in microsomal systems. J. Toxicol. Environ. Health 28, 205-220.   DOI   ScienceOn
23 Lee, E. S., Ju, H. K., Moon, T. C., Lee, E., Jahng, Y., Lee, S. H., Son, J. K., Baek, S. H. and Chang, H.W. (2004). Inhibition of nitric oxide and tumor necrosis factor-$\alpha$ (TNF-$\alpha$) production by propenone compound through blockade of nuclear factor (NF)-${\kappa}B$ activation in cultured murine macrophages. Biol. Pharm. Bull. 27, 617-620.   DOI   ScienceOn
24 Kurt-Jones, E. A., Hamberg, S., Ohara, J., Paul, W. E. and Abbas, A. K. (1987). Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness. J. Exp. Med. 166, 1774-1787.   DOI