Metabolism of Soyasaponin I by Human Intestinal Microflora and Its Estrogenic and Cytotoxic Effects |
Chang, Seo-Young
(Departments of Food and Nutrition, Kyung Hee University)
Han, Myung-Joo (Departments of Food and Nutrition, Kyung Hee University) Han, Sang-Jun (Departments of Pharmaceutical Science, Life and Nanopharmaceutical Sciences, Kyung Hee University) Kim, Dong-Hyun (Departments of Pharmaceutical Science, Life and Nanopharmaceutical Sciences, Kyung Hee University) |
1 | Okubo, K. I. M. (1992). Components responsible for the undesirable taste of soybean seeds. Biosci. Biotechnol. Biochem. 56, 99-103. DOI |
2 | Potter, J. D., Topping, D. L. and Oakenfull, D. G. (1979). Soya, saponins and plasma cholesterol. Lancet 1, 223-230. DOI ScienceOn |
3 | Rowlands, J. C., Berhow, M. A. and Badger, T. M. (2002). Estrogenic and antiproliferative properties of soy sapogenols in human breast cancer cells in vitro. Food Chem. Toxicol. 40, 1767-1774. DOI ScienceOn |
4 | Kudou, S., Tonomura, M., Tsukamoto, C., Uchida, T., Sakabe, T., Tamura, N. and Okubo, K. (1993). Isolation and structural elucidation of DDMP-conjugated soyasaponins as genuine saponins from soybean seeds. Biosci. Biotechnol. Biochem. 57, 546-550. DOI |
5 | Shutt, D. A., and Cox, R. I. (1972). Steroid and phyto-estrogen binding to sheep uterine receptors in vitro. J. Endocrinol. 52, 299-310. DOI ScienceOn |
6 | Lehmann, L., Esch, H. L., Wagner, J., Rohnstock, L. and Metzler, M. (2005). Estrogenic and genotoxic potential of equol and two hydroxylated metabolites of Daidzein in cultured human Ishikawa cells. Toxicol. Lett. 158, 72-86. DOI ScienceOn |
7 | Messina, J. M., Persky, V., Setchell, K. D. R. and Barnes, S. (1994). Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr. Cancer 21, 113-131. DOI ScienceOn |
8 | Shin, J., Bae, E. A., Lee, Y. C., Ma, J. Y. and Kim, D. H. (2006). Estrogenic effect of main components kakkalide and tectoridin of puerariae flos and their metabolites. Biol. Pharm. Bull. 29, 1202-1206. DOI ScienceOn |
9 | Voigt, W. (2005). Sulforhodamine B assay and chemosensitivity. Methods Mol. Med. 110, 39-48. DOI |
10 | Beck, V., Rohr, U. and Jungbauer, A. (2005). Phytoestrogens derived from red clover: an alternative to estrogen replacement therapy? J. Steroid Biochem. Mol. Biol. 94, 499-518. DOI ScienceOn |
11 | Kudou, S., Tonomura, M., Tsukamoto, C., Shimoyamada, M., Uchida, T. and Okubo, K. (1992). Isolation and structural elucidation of the major genuine soybean saponin. Biosci. Biotechnol. Biochem. 56, 142-143. DOI ScienceOn |
12 | Kim, D. H. (2002). Herbal medicines are activated by intestinal microflora. Nat. Prod. Sci. 8, 35-43. 과학기술학회마을 |
13 | Kitagawa, I., Taniyama, T., Nagahama, Y., Okubo, K., Yamauchi, F. and Yoshikawa, M. (1988). Structure of acetyl-soyasaponin A1, A2 and A3, astringent partially acetylated bisdesmoside of soyasapogenol A form american soybean, the seed of Glycine max MERRILL. Chem. Pharm. Bull. 36, 2819-2828. DOI |
14 | Tham, D. M., Gardner, C. D. and Haskell, W. L. (1998). Potential health benefits of dietary phytoestrogens: a review of clinical, epidemiological, and mechanistic evidence. J. Clin. Endocrinol. Metab. 83, 2223-2235. DOI |
15 | Boue, S. M., Tilghman, S. L., Elliott, S., Zimmerman, M. C., Williams, K. Y., Payton-Stewart, F., Miraflor, A. P., Howell, M. H., Shih, B. Y., Carter-Wientjes, C. H., Sega, R. C., Beckman, B. S., Wiese, T. E., Cleveland, T. E., McLachlan, J. A. and Burow, M. E. (2009). Identification of the potent phytoestrogen glycinol in elicited soybean (Glycine max). Endocrinology 150, 2446-2453. DOI ScienceOn |
16 | Cheeke, P. R. (1976). Nutritional and physiological properties of saponins. Nutr. Rep. Int. 13, 315-324. |
17 | Park, E. K., Shin, J., Bae, E. A., Lee, Y. C. and Kim, D. H. (2006). Intestinal bacteria activate estrogenic effect of main constituents puerarin and daidzin of Pueraria thunbergiana. Biol. Pharm. Bull. 29, 2432-2435. DOI ScienceOn |
18 | Hu, J., Zheng, Y. L., Hyde, W., Hendrich, S. and Murphy, P. A. (2004). Human fecal metabolism of soyasaponin I. J. Agric. Food. Chem. 52, 2689-2696. DOI ScienceOn |
19 | Messina, M. (1995). Modern applications for an ancient bean: soybeans and the prevention and treatment of chronic disease. J. Nutr. 125, 567S-569S. |
20 | Oakenfull, D. (1981). Saponins in food-a review. Food Chem. 6, 19-40. DOI ScienceOn |
21 | Price, K. R., Johnson, I. T. and Fenwick, G. R. (1987). The chemistry and biological significance of saponins in food and feeding stuffs. Crit. Rev. Food. Sic. Nutr. 26, 27-135. DOI ScienceOn |
22 | Bae, E. A., Choo, M. K., Park, E. K., Park, S. Y., Shin, H. Y. and Kim, D. H. (2003). Metabolism of ginsenoside by human intestinal bacteria and its related antiallergic activity. Biol. Pharm. Bull. 25, 743-747. DOI ScienceOn |
23 | Kobashi, K. and Akao, T. (1997). Relation of intestinal bacteria to pharmacological effects of glycosides. Biosci. Microflora. 16, 1-7. DOI |
24 | Joel, I. and Zhang, G. N. (2008). Soybean bioactive components and their implications to health-A review. Food Rev. International. 24, 252-276. DOI ScienceOn |
25 | John, S., Konesh, A., David, Y., Yukio, K., Gauri, M. and Yueming, J. (2004). Saponins from edile legumes: Chemistry, processing, and health benefits. J. Med. Food. 7, 67-78. DOI ScienceOn |
26 | Kim, S. L., Berhow, M. A., Kim, J. T., Chi, H. Y., Lee, S. J. and Chung, I. M. (2006). Evaluation of soyasaponin, isoflavone, protein, lipid, and free sugar accumulation in developing soybean seeds. J. Agric. Food. Chem. 54, 10003-10010. DOI ScienceOn |