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http://dx.doi.org/10.4062/biomolther.2009.17.4.335

Carboxylesterases: Structure, Function and Polymorphism  

Satoh, Tetsuo (Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, and HAB Research Laboratory, Ichikawa General Hospital)
Hosokawa, Masakiyo (Laboratory of Drug Metabolism and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba Institute of Science)
Publication Information
Biomolecules & Therapeutics / v.17, no.4, 2009 , pp. 335-347 More about this Journal
Abstract
This review covers current developments in molecular-based studies of the structure and function of carboxylesterases. To allay the confusion of the classic classification of carboxylesterase isozymes, we have proposed a novel nomenclature and classification of mammalian carboxylesterases on the basis of molecular properties. In addition, mechanisms of regulation of gene expression of carboxylesterases by xenobiotics, and involvement of carboxylesterase in drug metabolism are also described.
Keywords
Carboxylesterase; Genetic polymorphism; Molecular structure; Classification;
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