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http://dx.doi.org/10.4062/biomolther.2009.17.3.270

Attenuated Cerebral Ischemic Injury by Polyethylene Glycol-Conjugated Hemoglobin  

Cho, Geum-Sil (Department of Neuroscience, College of Medicine, Korea University)
Choi, In-Young (Department of Neuroscience, College of Medicine, Korea University)
Choi, Yoo-Keum (Department of Neuroscience, College of Medicine, Korea University)
Kim, Seul-Ki (Department of Neuroscience, College of Medicine, Korea University)
Cai, Ying (Department of Neuroscience, College of Medicine, Korea University)
Nho, Kwang (SunBio Inc.)
Lee, Jae-Chul (Clinical Research Institute, Seoul National University Hospital)
Publication Information
Biomolecules & Therapeutics / v.17, no.3, 2009 , pp. 270-275 More about this Journal
Abstract
Polyethylene glycol-conjugated hemoglobin (PEG-Hb) has been proposed as a blood substitute for transfusion due to their plasma expansion and oxygen transport capabilities. The protective effect of PEG-Hb on cerebral hypoxic-ischemic injury was investigated in neonatal hypoxia model and adult rat focal cerebral ischemia model. As intravenously administered 30 min before the onset of hypoxia, PEG-Hb markedly protected cerebral hypoxic injury in a neonatal rat hypoxia model. A similar treatment of PEG-Hb largely reduced the ischemic injury ensuing after 2-h middle cerebral artery occlusion followed by 22-h reperfusion. Consistently, neurological disorder was significantly improved by PEG-Hb. The results indicate that the pharmacological blockade of cerebral ischemic injury by using PEG-Hb may provide a useful strategy for the treatment of cerebral stroke.
Keywords
Polyethylene glycol-conjugated hemoglobin; Hypoxia; Focal cerebral ischemia;
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