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http://dx.doi.org/10.4062/biomolther.2009.17.2.199

Evaluation for Protective Effect of Rutin, a Natural Flavonoid, against HCl/Ethanol-Induced Gastric Lesions  

Jeong, Choon-Sik (Department of Pharmacy, Duksung Women's University)
Publication Information
Biomolecules & Therapeutics / v.17, no.2, 2009 , pp. 199-204 More about this Journal
Abstract
In this study we investigated the protective effects of rutin, a natural plant flavonoid, on HCl/ethanol-induced gastric lesions in rats. Rutin showed the antioxidant activities, the acid-neutralizing capacities, and the inhibitory effects on the growth of Helicobacter pylori (H. pylori.), which are equivalent to control compounds. In addition, rutin significantly inhibited HCl/ethanol-induced gastric lesions. Antigastritic action of rutin may be associated with the antioxidant activities, acid-neutralizing capacities, anti-H. pylori action, and the stimulation of mucus secretion. From these results, we could suggest that rutin may be useful for the treatment and/or protection of gastritis.
Keywords
Rutin; Anti-gastric activity; Antioxidant; Anti-Helicobacter pylori; HCl/ethanol-induced gastric lesion;
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1 Troll, W. and Wiesner, R. (1985). The role of oxygen radicals as a possible mechanism of tumor promotion. Annu. Rev. Pharmacol. Toxicol. 25, 509-528   DOI   ScienceOn
2 Welage, L. S. (2003). Pharmacologic properties of proton pump inhibitors. Pharmacotherapy 23, 74S-80S   DOI   ScienceOn
3 Kinoshita, M., Noto, T. and Tamaki, H. (1995). Effect of a combination of ecabet sodium and cimetidine on experimentally induced gastric lesions and gastric mucosal resistance to ulcerogenic agents in rats. Biol. Pharm. Bull. 18, 223-226   DOI   ScienceOn
4 Kreft, S., Knapp, M. and Kreft, I. (1999). Extraction of rutin from buckwheat (Fagopyrum esculentum Moench) seeds and determination by capillary electrophoresis. J. Agric Food Chem. 47, 4649-4652   DOI   ScienceOn
5 Kuntz, S., Wenzel, U. and Daniel, H. (1999). Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. Eu.r J. Nutr. 38, 133-142   DOI
6 Kitagawa, H., Takeda, F. and Kohei, H. (1986). A simple method for estimation of gastric mucus and effects of antiulcerogenic agents on the decrease in mucus during water-immersion stress in rats. Arzneimittel Forschung 36, 1240-1244
7 Shay, H., Komarov, S. A., Fels, S. S. and Meranze, D. (1945). A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 4, 43-61
8 Leirisalo-Repo, M., Paimela, L., Koskimies, S. and Repo, H. (1993). Functions of polymorphonuclear leukocytes in early rheumatoid arthritis. Inflammation 17, 427-442   DOI
9 Saija, A., Scalese, M., Lanza, M., Marzullo, D., Bonina, F. and Castelli, F. (1995). Flavonoids as antioxidant agents: importance of their interaction with biomembranes. Free Radic. Biol. Med. 19, 481-486   DOI   ScienceOn
10 Sertie, J. A. A., Carvalho, J. C. T. and Panizza, S. (2000). Antiulcer activity of the crude extract from the leaves of Casearia sylvestris. Le Pharmacien Biologiste 38, 112-119
11 Tomohiro, T., Futoshi, K., Naoharu, W., Akihito, Y. and Kanzo, S. (1994). A simple screening method for antioxidants and isolation of several antioxidants produced by marine bacteria from fish and shellfish. Biosci. Biotechnol. Biochem. 58, 1780-1783   DOI
12 Pisegna, J. R. (2002). Pharmacology of acid suppression in the hospital setting: focus on proton pump inhibition. Crit. Care Med. 30, S356-S361   DOI   ScienceOn
13 Seiki, M., Ukei, S., Tanaka, Y. and Soeda, M. (1990). Studies of anti-ulcer effects of a new compound, zinc L-carnosine (Z-103). Nippon Yakurigaku Zasshi 95, 257-269   DOI
14 Drake, I. M., Mapstone, N. P., Schorah, C. J., White, K. L., Chalmers, D. M., Dixon, M. F. and Axon, A. T. (1998). Reactive oxygen species activity and lipid peroxidation in Helicobacter pylori associated gastritis: relation to gastric mucosal ascorbic acid concentrations and effect of H. pylori eradication. Gut 42, 768-771   DOI   ScienceOn
15 International Agency for Research on Cancer (1994). Schistosomes, liver fluke s and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. IARC Monogr Eval Carcinog Risks Hum. 61, 1-241
16 Kahraman, A., Erkasap, N., Koken, T., Serteser, M., Aktepe, F. and Erkasap, S. (2003). The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions. Toxicology 183, 133-142   DOI   ScienceOn
17 McQuaid, K. R. and Isenberg, J. I. (1992). Medical therapy of peptic ulcer disease. Surg Clin. North Am. 72, 285-316   DOI
18 Neugut, A. I., Hayek, M. and Howe, G. (1996). Epidemiology of gastric cancer. Semin. Oncol. 3, 281-291
19 Nostro, A., Cellini, L., Di Bartolomeo, S., Di Campli, E., Grande, R., Cannatelli, M. A., Marzio, L. and Alonzo, V. (2005). Antibacterial effect of plant extracts against Helicobacter pylori. Phytother. Res. 19, 198-202   DOI   ScienceOn
20 Afanas'eva, I. B., Ostrakhovitch, E. A., Mikhal'chik, E. V., Ibragimova, G.A. and Korkina, L.G. (2001). Enhancement of antioxidant and anti-inflammatory activities of bioflavonoid rutin by complexation with transition metals. Biochem. Pharmacol. 61, 677-684   DOI   ScienceOn
21 Bae, E. A., Han, M. J. and Kim, D. H. (1999). In vitro anti-Helicobacter pylori activity of some flavonoids and their metabolites. Planta Med. 65, 442-443   DOI   ScienceOn
22 Tarnawski, A., Tanoue, K., Santos, A. M. and Sarfeh, I. J. (1995). Cellular and molecular mechanisms of gastric ulcer healings. Scand. J. Gastroenterol. 210(Suppl), 9-14   DOI
23 Hong, J. Y., Pyee, J. H., Lee, S. K., Cho, Y. J., Song, S. H. and Park, H. J. (1998). Antioxidant, antiinflamatory, and antiproliferative activities of strawberry extracts. Biomol. Ther. 16, 286-292
24 Lee, E. J., Kim, K. S., Jung, H. Y., Kim, D. H. and Jang, H. D. (2005). Antioxidant activities of garlic (Allium sativum L.) with growing districts. Food. Sci. Biotechnol. 14, 123-130   과학기술학회마을
25 Oyaizu, M. (1986). Studies on product of browning reaction: antioxidative activities of products of browning reaction prepared from glucosamine. Jap. J. Nutr. 44, 307-315   DOI