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http://dx.doi.org/10.4062/biomolther.2009.17.1.62

Suppressive Actions of Astragali Radix (AR) Ethanol Extract and Isolated Astragaloside I on HCl/ethanol-Induced Gastric Lesions  

Jeong, Jeong-Suk (College of Pharmacy, Duksung Women's University)
Lee, Je-Hyuk (Plant Resources Research Institute, Duksung Women's University)
Lee, Sang-Hyup (College of Pharmacy, Duksung Women's University)
Kang, Sam-Sik (College of Pharmacy, Seoul National University)
Jeong, Choon-Sik (College of Pharmacy, Duksung Women's University)
Publication Information
Biomolecules & Therapeutics / v.17, no.1, 2009 , pp. 62-69 More about this Journal
Abstract
Roots of Astragalus membranaceus (A. membranaceus) (Astragali Radix, AR) has been used as a herbal medicine for gastrointestinal disorders in China, Korea, Japan, and other Asia countries. In this study we investigated the effects of the AR 70% ethanol extract and compounds isolated from AR on gastritis in rats and growth of human gastric cancer cells. AR 70% ethanol extract showed the potent acid-neutralizing capacities and partly cytotoxicity of Helicobacter pylori and human AGS gastric cancers cell. Astragaloside I and daucosterol, which were isolated from AR, significantly inhibited HCl/ethanol-induced gastric lesions. In addition, daucosterol increased the mucus content to almost the same as the positive control. The results of this study suggest that astragaloside I and daucosterol may be good candidates for the development of new drugs or neutraceuticals which can be used for the treatment or prevention of gastritis.
Keywords
Astragalus membranaceus; Astragali Radix (AR); Astragaloside I; Gastritis; Helicobacter pylori;
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