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http://dx.doi.org/10.4062/biomolther.2009.17.1.43

Inhibition of T-cell-Dependent Antibody Production by Quercetin in Mice  

Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University)
Publication Information
Biomolecules & Therapeutics / v.17, no.1, 2009 , pp. 43-46 More about this Journal
Abstract
The immunosuppressive properties of flavonoids were examined for the first time by testing their effects on T-cell-mediated antibody production, using a classical plague-forming cell (PFC) assay in mice. Among the tested flavonoids including naringenin, chrysin, flavonol, galangin, quercetin, morin, myricetin and biochanin A, only quercetin, orally administered at 25 mg/kg, significantly inhibited the number of IgMproducing PFCs induced by sheep red blood cells (SRBC). Interestingly, biochanin A (isoflavone) increased the number of PFCs, suggesting an immunostimulatory effect. The other flavonoids tested did not inhibit or enhance PFC response significantly. Quercetin was also found to show thymus atrophy dose-dependently at 5-500 mg/kg. All these results indicate that quercetin inhibits in vivo antibody production probably by inhibiting T-cell function.
Keywords
Flavonoid; Quercetin; Immunosuppression; Plague-forming cell assay;
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