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http://dx.doi.org/10.4062/biomolther.2008.16.4.416

Antihistamine Activities of Iminodiacetamide Derivatives  

Rhee, Soo-Jin (School of Pharmacy, Ewha Womans University)
Kam, Yoo-Lim (School of Pharmacy, Ewha Womans University)
Seo, Young-Hee (School of Pharmacy, Ewha Womans University)
ParkChoo, Hea-Young (School of Pharmacy, Ewha Womans University)
Publication Information
Biomolecules & Therapeutics / v.16, no.4, 2008 , pp. 416-424 More about this Journal
Abstract
A series of N,N'-substituted iminodiacetamide derivatives was synthesized and evaluated their inhibitory effects on the histamine-induced smooth muscle contraction in guinea-pig ileum and on the histamine release from IgE-sensitized RBL-2H3 cells (rat basophilic leukemia cell line). Compounds A3, A4 and A5 which have 1-(4-chlorobenzhydryl) piperazine moiety, showed both moderate antihistamine activity and histamine release inhibitory activity.
Keywords
Iminodiacetamide; Allergy; Antihistamine; Guinea-pig ileum; Histamine release; RBL-2H3;
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