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http://dx.doi.org/10.4062/biomolther.2008.16.4.343

The Scutellaria Flavone, Oroxylin A, Improves Attention-Deficit/Hyperactivity Disorder Related Behaviors in Spontaneously Hypertensive Rats  

Yoon, Seo-Young (Department of Pharmacy, Sahmyook University)
Chun, Mi-Sook (Department of Pharmacy, Sahmyook University)
Lee, Yong-Soo (Department of Pharmacology College of Pharmacy, Duksung Women's University)
Park, Hae-Il (College of Pharmacy, Kangwon National University)
Shin, Chan-Young (Department of Pharmacology College of Medicine, Konkuk University)
Ryu, Jong-Hoon (Department of Oriental Pharmaceutical Science College of Pharmacy, KyungHee University)
Cheong, Jae-Hoon (Uimyung Institute for Neuroscience, Sahmyook University)
Publication Information
Biomolecules & Therapeutics / v.16, no.4, 2008 , pp. 343-350 More about this Journal
Abstract
Oroxylin A is a flavonoid isolated from Scutellaria baicalensis, which is one of the most important medicinal herbs in traditional Korean medicine. In this study, we investigated the psychopharmacological activities of oroxylin A using the open field, rota-rod, balanced wire and plus-maze tests in Spontaneously Hypertensive Rats (SHR) and Wistar Kyoto Rats (WKY). Oroxylin A reduced hyperactivity in SHR (ADHD animal model) although it tended to increase locomotor activity in WKY. Methylphenidate did not reduce hyperactivity. Oroxylin A alleviated impulsive behaviors such as rearing, the percentage of moving time to the central area and the tendency to move into an unstable condition (open area in elevated plus-maze). Methylphenidate also reduced the percentage of staying time in the central area and the tendency to move into an unstable condition. Both oroxylin A and methylphenidate enhanced motor attention in SHR and WKY. Oroxylin A antagonized the muscimol ($GABA_A$ receptor agonist)-induced $Cl^-$current and its action was similar to that of bicuculline ($GABA_A$ receptor antagonist). The effects of oroxylin A may be caused by the antagonism at the $GABA_A$ receptor. Thus, oroxylin A may be a candidate of drug for treatment of ADHD.
Keywords
Scutellaria flavone; Behavior; Oroxylin A; ADHD; GABA;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
Times Cited By Web Of Science : 2  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
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