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http://dx.doi.org/10.4062/biomolther.2008.16.3.286

Antioxidant, Antiinflamatory, and Antiproliferative Activities of Strawberry Extracts  

Hong, Ji-Young (College of Pharmacy, Ewha Womans University)
Song, Su-Hyun (College of Pharmacy, Ewha Womans University)
Park, Hyen-Joo (College of Pharmacy, Ewha Womans University)
Cho, Yong-Jin (Food Nano-Biotechnology Research Center, Korea Food Research Institute)
Pyee, Jae-Ho (College of Natural Sciences, Dankook University)
Lee, Sang-Kook (College of Pharmacy, Ewha Womans University)
Publication Information
Biomolecules & Therapeutics / v.16, no.3, 2008 , pp. 286-292 More about this Journal
Abstract
Strawberry is widely consumed in diet and has been attracted much attention due to its potential for human health benefits. Strawberry contains a diverse range of phytochemicals but the biological activities with molecular mechanisms are poorly elucidated yet. In this study, the effects of the extracts of strawberry (Maehyang cultivar) on antioxidant, antiinflammatory, and antiproliferative potential against various cancer cells were investigated. The strawberry extracts (SE) of Maehyang cultivar showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activities. In addition, SE inhibited the growth of human colon (HCT-116), lung (A549), stomach (SNU-638) and fibrosarcoma (HT-1080) cancer cells. The strawberry extracts also exhibited the inhibitory effect on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production and suppressed LPS-induced inducible nitric oxide synthase (iNOS) protein and mRNA expression in mouse macrophage RAW 264.7 cells. These findings suggest that the strawberry extracts (Maehyang cultivar) might have antioxidant, antiinflammotry, and anticancer activities.
Keywords
Strawberry; Maehyang; Antioxidant; Anti-inflammation; Nitric oxide; Antiproliferation of cancer cells;
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