Protective Effect of ACTIValoe N-931 Complex, a Mixture of Aloe vera and Silybum marianum, on Experimental Acute Liver Injury
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Moon, Young-Joo
(College of Pharmacy, Sungkyunkwan University)
Cheon, Ho-Jun (College of Pharmacy, Sungkyunkwan University) Lee, Woo-Cheol (College of Pharmacy, Sungkyunkwan University) Kim, Hyo-Yeon (College of Pharmacy, Sungkyunkwan University) Oh, Sun-Tack (Univera, Inc., ECONET CENTER) Shin, Eun-Ju (Univera, Inc., ECONET CENTER) Shim, Kyu-Suk (Univera, Inc., ECONET CENTER) Lee, Sun-Mee (College of Pharmacy, Sungkyunkwan University) |
1 | Farber, E., Shull, K. H., Villa-trevino, S., Lombardi, B. and Thomas, M. (1964). Biochemical pathology of acute hepatic adenosinetriphosphate deficiency. Nature 203, 34-40 DOI ScienceOn |
2 | Galati, E. M., Mondello, M. R., Lauriano, E. R., Taviano, M. F., Galluzzo,M. and Miceli, N. (2005). Opuntia ficus indica (L.) Mill. fruit juice protects liver from carbon tetrachloride-induced injury. Phytother. Res. 19, 796-800 DOI ScienceOn |
3 | Gonzalez, R., Collado, J. A., Nell, S., Briceno, J., Tamayo, M. J., Fraga, E., Bernardos, A., Lopez-Cillero, P., Pascussi, J. M., Rufian, S., Vilarem, M. J., De la Mata, M., Brigelius-Flohe, R., Maurel, P. and Muntane, J. (2007). Cytoprotective properties of alpha-tocopherol are related to gene regulation in cultured D-galactosamine-treated human hepatocytes. Free Radic. Biol. Med. 43, 1439-1452 DOI ScienceOn |
4 | Griffith, O. W. (1980). Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106, 207-212 DOI ScienceOn |
5 | Karaa, A., Kamoun, W. S. and Clemens, M. G. (2005). Chronic ethanol sensitizes the liver to endotoxin via effects on endotherial nitric oxide synthesis regulation. Shock 24, 447-454 DOI ScienceOn |
6 | Koff, R. S., Fitts, J. J., Sabesin, S. M. and Zimmerman, H. J. (1971). D-galactosamine hepatotoxicity. II. Mechanism of fatty liver production. Proc. Soc. Exp. Biol. Med. 138, 89-92 DOI |
7 | Lim, B. O., Seong, N.S., Choue, R. W., Kim, J. D., Lee, H. Y., Kim, S. Y., Yu, B. P., Jeon, T. I. and Park, D. K. (2003). Efficacy of dietary Aloe vera supplementation on hepatic cholesterol and oxidative status in aged rats. J. Nutr. Sci. Vitaminol. 49, 292-296 DOI ScienceOn |
8 | Lu, K. L., Tsai, C. C., Ho, L. K., Lin, C. C. and Chang, Y. S. (2002). Preventive effect of the Taiwan folk medicine Ixeris laevigata var. old hami on a naphthylisothiocyanate and carbon tetrachloride. Phytother. Res. 1, S45-50 |
9 | Bartels, H. and Hohorst, H. J. (1963). On the effect of ethionine on the metabolite status of the rat liver. Biochim. Biophys. Acta 71, 214-216 DOI |
10 | Buege, T. A. and Aust, S. D. (1978). Microsomal lipid peroxidation. Methods Enzymol. 52, 302-310 DOI |
11 | Can, A., Akev, N., Ozsoy, N., Bolkent, S., Arda, B. P., Yanardag, R. and Okyar, A. (2004). Effect of Aloe vera leaf gel and pulp extracts on the liver in type-II diabetic rat models. Biol. Pharm. Bull. 27, 694-698 DOI ScienceOn |
12 | Chandan, B. K., Saxena, A. K., Shukla, S., Sharma, N., Gupta, D. K., Suri, K. A., Suri, J., Bhadauria, M. and Singh, B. (2007). Hepatoprotective potential of Aloe barbadensis Mill.against carbon tetrachloride induced hepatotoxicity. J. Ethnopharmacol. 111, 560-566 DOI ScienceOn |
13 | Park, S. W., Lee C. H., Kim, Y. S., Kang, S. S. and Lee, S. M. (2008) Protective effect of bicalin against carbon tetrachloride- induced acute hepatic injury in mice. J. Pharmacol Sci. 106, 136-143 DOI ScienceOn |
14 | Plaa, G. L. and Priestly, B. G. (1976). Intrahepatic cholestasis induced by drugs chemicals. Pharmacol. Rev. 28, 207-273 |
15 | Haibior, A., Walewska-Zielecka, B. and But ruk, E. (1994). Hepatocellular cholestasis liver injury due to amoxycillian-clavulanic acid combination. Clin. Inves. 72, 616-618 |
16 | Kaplowitz, J. and Wilkerson, L. (2002). Reaching and teaching new medical students. Acad. Med. 77, 1173 DOI ScienceOn |
17 | Hatta, S., Suzuki, Y., Miyamoto, A., Take mura, H. and Ohshika, H. (1986). Effects of 8-(2-dimethylaminoethyl)-3-oxo-4-phenyl- 1-thia-4,8-diazaspiro[4,5]decane dihydrochloride monohydrate (Y-8845) on carbontetrachloride-induced liver injury. Japan J. Pharmacol. 40, 561-567 DOI |
18 | Ijaz, S., Yang, W., Winslet, M. C. and Seifalian, A. M. (2003). Impairment of hepatic microcirculation in fatty liver. Microcirculation 10, 447-456 DOI ScienceOn |
19 | Jaeschke, H. (2002). Redox considerations in hepatic injury and inflammation. Antioxid. Redox Signal 4, 699-700 DOI ScienceOn |
20 | MacDonald, J. R., Beckstead, J. H. and Smuckler, E. A. (1987). An ultrastructural and histochemical study of the prominent inflammatory response in D (+)-galactosamine hepatotoxicity. Br. J. Exp. Pathol. 68, 189-199 |
21 | Morikawa, J., Habuchi, Y., Nishio, M., Yamamoto, T., Tanaka, H. and Kashima, K. (1996). Delineation of premature P waves on four-dimensional electrocardiography, a new display of electrical forces by computer techniques. Angiology 47, 1101-1106 DOI ScienceOn |
22 | Nakama, T., Nureki, O. and Yokoyama, S. (2001). Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase. J .Biol. Chem. 276, 47387-47393 DOI ScienceOn |
23 | Nakayama, S., Yamauchi, M. and Oguchi, S. (1989). A comparative study of Laennec by intravenous or subcutaneous injection on CCl4-induced acute or chronic liver injury in rats. Nippon Yakurigaku Zasshi 94, 137-144 DOI ScienceOn |
24 | Post-White, J., Ladas, E. J. and Kelly, K. M. (2007). Advances in the use of milk thistle (Silybum marianum). Integr. Cancer. Ther. 6, 158-165 DOI |
25 | Ohnishi, N., and Yokoyama, T. (2004). Interaction between medicines and functional foods or dietary supplements. Keio J Med. 53, 137-150 DOI |
26 | Waterfield, C. J., Westmoreland, C., Asker, D. S., Murdock, J. C., George, E. and Timbrell, J. A. (1998). Ethionine toxicity in vitro: the correlation of data from rat hepatocyte suspensions and monolayers with in vivo observations. Arch. Toxicol. 72, 588-596 DOI |
27 | Zimmerman, H. J. (1978). Drug-induced liver disease. Drugs 19, 25-45 |
28 | Tietze, F. (1969). Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem. 27, 502-522 DOI ScienceOn |
29 | Roch, R. A. and Dahm, L. J. (1997). Neutrophil-and glutathiomediated hepatotoxicity of a-naphthyliosothiocyanate. Drug Metab. Rev. 29, 153-165 DOI |
30 | Roth, R. A., Harkema, J. R., Pestka, J. P. and Ganey, P. E. (1997). Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents? Toxicol. Appl. Pharmacol. 147, 300-311 DOI ScienceOn |
31 | Vaknin, Y., Hadas, R., Schafferman, D., Murkhovsky, L. and Bashan, N. (2007). The potential of milk thistle (Silybum marianum L.), an Israeli native, as a source of edible sprouts rich in antioxidants. Int. J .Food Sci. Nutr. 20, 1-8 |
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