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http://dx.doi.org/10.4062/biomolther.2008.16.2.095

Fumonisin B1 Induces Apoptosis in Sphingosine 1-Phosphate Lyase-null F9 Cells through Increase of Sphingolipids Levels  

Pak, Seon-Mi (College of Pharmacy, Chungbuk National University)
Park, Nam-Young (College of Pharmacy, Chungbuk National University)
Park, Myung-Yong (College of Pharmacy, Chungbuk National University)
Kim, Wan-Jong (Department of Life Sciences, Soonchunhyang University)
Lee, Jong-Hwa (Department of Life Sciences, Soonchunhyang University)
Oh, Sei-Kwan (Department of Neuroscience, School of Medicine, Ewha Womans University)
Yoo, Hwan-Soo (College of Pharmacy, Chungbuk National University)
Lee, Yong-Moon (College of Pharmacy, Chungbuk National University)
Publication Information
Biomolecules & Therapeutics / v.16, no.2, 2008 , pp. 95-99 More about this Journal
Abstract
Apoptosis is essential for a variety of pathophysiological progress. Apoptosis induction by various agents changes cellular morphology, DNA content and lipid membrane composition. Recently, sphingosine 1-phosphate (S1P) is avidly released from not only platelets and erythrocytes but vascular endothelium. Here we established S1P releasing cells by deleting S1P lyase (F9-12 cells). We observed apoptosis induction by the treatment of fumonisin B1 (FB1) in F9-12 cells but not in F9 wild-type cells. We measured high amounts of accumulated S1P and dihydroS1P (DHS1P) in FB1-induced apoptotic F9-12 cells. We also showed DHS1P release in an early stage of the apoptosis induction by FB1 but not by phorbol 12-myristate 13-acetate (PMA)-induced apoptosis, suggesting differential apoptotic processes.
Keywords
Apoptosis; Sphingosine 1-phosphate; Release; F9 cells; HPLC;
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