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http://dx.doi.org/10.4062/biomolther.2008.16.2.132

Anti-angiogenic, Anti-inflammatory and Anti-nociceptive Activities of Vanillin in ICR Mice  

Lim, Eun-Ju (College of Pharmacy, Sookmyung Women's University)
Kang, Hyun-Jung (Division of Life Sciences and Research Institute of Life Sciences, Kangwon National University)
Jung, Hyun-Joo (College of Pharmacy, Sookmyung Women's University)
Song, Yun-Seon (College of Pharmacy, Sookmyung Women's University)
Lim, Chang-Jin (Division of Life Sciences and Research Institute of Life Sciences, Kangwon National University)
Park, Eun-Hee (College of Pharmacy, Sookmyung Women's University)
Publication Information
Biomolecules & Therapeutics / v.16, no.2, 2008 , pp. 132-136 More about this Journal
Abstract
The current study aimed to assess some novel pharmacological activities of vanillin. Vanillin inhibited the chick chorioallantoic membrane (CAM) angiogenesis. Vanillin had anti-inflammatory activity using the acetic acid-induced permeability model in mice. Anti-nociceptive activity of vanillin was shown using the acetic acid-induced writhing test in mice. Vanillin inhibited production of nitric oxide (NO) and induction of inducible nitric oxide synthase (iNOS) but not cyclooxygenase-2 (COX-2) in the lipopolysaccharide (LPS)-activated RAW264.7 macrophages. Vanillin decreased the level of iNOS mRNA in the LPS-activated macrophages. Taken together, these results suggest that vanillin can have anti-angiogenic, anti-inflammatory and anti-nociceptive activities in ICR Mice.
Keywords
vanillin; anti-angiogenic; anti-nociceptive; anti-inflammatory; nitric oxide;
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