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Antioxidant and Anti-Nociceptive Activities of Ulmus davidiana var. japonica  

Jung, Hyun-Joo (College of Pharmacy, Sookmyung, Women's University)
Kang, Hyun-Jung (Division of Life Sciences and Research Institute of Life Sciences, Kangwon National University)
Song, Yun-Seon (College of Pharmacy, Sookmyung, Women's University)
Lim, Chang-Jin (Division of Life Sciences and Research Institute of Life Sciences, Kangwon National University)
Park, Eun-Hee (College of Pharmacy, Sookmyung, Women's University)
Publication Information
Biomolecules & Therapeutics / v.16, no.1, 2008 , pp. 9-13 More about this Journal
Some pharmacological activities of Ulmus davidiana var. japonica were evaluated using its methanol extract (UDE). An acute anti-inflammatory activity of UDE was assessed using carrageenan-induced hind paw edema in rats. UDE exhibited an antioxidant activity when assayed by a stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH). Dose-dependent anti-nociceptive activity of UDE was assessed using the acetic acid-induced writhing test in mice. UDE was able to diminish the reactive oxygen species (ROS) level in the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. UDE also suppressed production of nitric oxide and induction of inducible nitric oxide synthase and cyclooxygenase-2 in the stimulated macrophages cells. collectively, the results imply that U. davidiana var. japonica has antioxidant and anti-nociceptive activities in addition to anti-inflammatory activity.
Ulmus davidiana var. japonica; anti-nociceptive; anti-inflammatory; antioxidant; nitric oxide; reactive oxygen species;
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1 Son, Y. O., Lee, K. Y., Choi, K. C., Chung, Y., Kim, J. G., Jeon, Y. M., Jang, Y. S. and Lee, J. C. (2004). Inhibitory effects of glycoprotein-120 (G-120) from Ulmus davidiana Nakai on cell growth and activation of matrix metalloproteinases. Mol. Cells 18, 163-170
2 Ko, J. H., Lee, S. J. and Lim, K.T. (2005). 116 kDa glycoprotein isolated Ulmus davidiana Nakai (UDN) inhibits glucose/glucose oxidase (G/GO)-induced apoptosis in BNL CL.2 cells. J. Ethnopharmacol. 100, 339-346   DOI   ScienceOn
3 Koster, R., Anderson, M. and Beer, E.J. (1959). Acetic acid for analgesic screening. Fed. Proc. 18, 42
4 Lee, J. C., Lee, K. Y., Son, Y. O., Choi, K. C., Kim, J., Truong, T. T. and Jang, Y. S. (2005). Plant-originated glycoprotein, G-120, inhibits the growth of MCF-7 cells and induces their apoptosis. Food Chem. Toxicol. 43, 961-968   DOI   ScienceOn
5 Lee, S. J. (1966). Korean Folk Medicine, Monographs Series No. 3, Seoul National University Press, Seoul, Korea, p. 39
6 Franzotti, E. M., Santos, C. V. F., Rodrigues, H. M. S. L., Mourao, R. H. V., Andrade, M. R. and Antoniolli, A.R. (2000). Anti-inflammatory, analgesic and acute toxicity of Sida cardiafolia L. J. Ethnopharmacol. 72, 273-277   DOI   ScienceOn
7 Jachak, S. M. (2006), Cyclooxygenase inhibitory natural products: current status. Curr. Med. Chem. 13, 659-678   DOI   ScienceOn
8 Kim, K. S., Lee, S. D., Kim, K. H., Kil, S. Y., Chung, K. H. and Kim, C.H. (2005). Suppressive effects of a water extract of Ulmus davidiana Planch (Ulmaceae) on collagen- induced arthritis in mice. J. Ethnopharmacol. 97, 65-71   DOI   ScienceOn
9 Lim, K. T., Son, Y. O., Lee, J. C., Lim, J. C. and Chung, Y. (2002). Effects of glycoprotein from Ulmus davidiana Nakai on hydroxyl radical induced-cytotoxicity, and on activation of nuclear factor-kappa B and activator protein- 1 in cultured mouse primary thymocytes. Food Sci. Technol. 11, 172-178
10 Park, E. H., Joo, M. H., Kim, S. H. and Lim, C.J. (2003). Antiangiogenic activity of Gardenia jasminoides fruit. Phytother. Res. 17, 961-962   DOI   ScienceOn
11 Royall, J. A. and Ischiropoulos, H. (1993). Evaluation of 2',7'-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular $H_2O_2$ in cultured endothelial cells. Arch. Biochem. Biophys. 302, 348-355   DOI   ScienceOn
12 Sherman, M. P., Aeberhard, E. E., Wong, V. Z., Griscavage, J. M. and Ignarro, L. J. (1993). Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages. Biochem. Biophys. Res. Commun. 191, 1301-1308   DOI   ScienceOn
13 Singh, V. K., Mehrotra, S., Narayan, P., Pandey, C. M. and Agarwal, S.S. (2000). Modulation of autoimmune diseases by nitric oxide. Immunol. Res. 22, 1-19   DOI   ScienceOn
14 Winter, C. A., Risley, E. A. and Nuss, G.W. (1962). Carrageenan- induced oedema in hind paw of the rats as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med. 111, 544-547   DOI
15 Song, Y. S., Kim, S. H., Sa, J. H., Jin, C., Lim, C. J. and Park, E.H. (2004). Anti-angiogenic and inhibitory activity on inducible nitric oxide production of the mushroom Ganoderma lucidum. J. Ethnopharmacol. 90, 17-20   DOI   ScienceOn
16 Lee, S. J., Heo, K. S., Oh, P. S., Lim, K. and Lim, K.T. (2004). Glycoprotein isolated Ulmus davidiana Nakai inhibits TPA-induced apoptosis through nuclear factorkappa B in NIH3T3 cells. Toxicol. Lett. 146, 159-174   DOI   ScienceOn