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http://dx.doi.org/10.4062/biomolther.2007.15.4.230

Hematopoietic Effect of Phellinus linteus Polysaccharide in Mouse Splenocytes and Bone Marrow Cells  

Won, Tae-Joon (Department of Immunology, College of Pharmacy, Chung-Ang University)
Kim, Min-Soo (Department of Immunology, College of Pharmacy, Chung-Ang University)
Woo, Jong-Shick (Department of Immunology, College of Pharmacy, Chung-Ang University)
Han, Sang-Beom (Department of Immunology, College of Pharmacy, Chung-Ang University)
Hwang, Kwang-Woo (Department of Immunology, College of Pharmacy, Chung-Ang University)
Publication Information
Biomolecules & Therapeutics / v.15, no.4, 2007 , pp. 230-234 More about this Journal
Abstract
In anti-cancer therapies, radiotherapy and chemotherapy show a superior inhibition effect on cancer cell growth, but those are very toxic to normal tissues and organs. Particularly, drugs for neutropenia, one of chemotherapy agents, which suppress the function of bone marrow, are needed to be controlled in terms of their dosage and therapy period because of their side effect. Phellinus linteus polysaccharide (PL) has been reported to increase the number of splenocytes and bone marrow cells. PL has been shown to decrease the side effects of cyclophosphamide (CYC) treatment to the cancer patients. PL showed no effects in semisolid clonogenic assay, suggesting that PL doesn't contain substantial compounds to substitute for colony stimulating factors (CSFs). On the other hand, PL increased the expression of SCF, IL-3, GM-CSF, TPO genes. These results indicate that PL may promote the growth and proliferation of splenocytes and bone marrow cells through indirect or CSFs-dependent pathway, which may lead to a hematopoiesis.
Keywords
hematopoiesis; Phellinus lintus polysaccharide; splenocytes; bone marrow; colony stimulating factors;
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  • Reference
1 Chung, K. S., Kim, S. S., Kim, H. S., Han, M. W. and Kim, B. K. (1994). Antitumor activity of Kp, a protein-polysaccharide from the mycelial culture of Phellinus linteus. Chem. Pharm. Bull. 44, 1093-1095
2 Mansell, P. W. A., Ichinose, H., Reed, R. H., Krementz, E. T., Mcnamee, R. and Di Luzio Jr, R. (1975). Macrophage-mediated destruction of human malignant cells in vitro. J. Natl. Cancer. Inst. 54, 571-580
3 Naglieri, E., Gebbia, V., Durini, E., Lelli, G., Abbate, I., Selvaggi, F. P., Di Tonno, P. and Colucci, G. (1998). Standard interleukin-2(IL-2) and interferon-alpha immunotherapy versus an IL-2 and 4-epirubicin immunochemotherapeutic association in metastatic renal cell carcinoma. Anticancer Res. 18, 2021-2026
4 Arai, K., Lee, F., Miyajima, A., Miyatake, S., Arai, N. and Yokota, T. (1990). Cytokines: coordinators of immune and inflammatory responses. Annu. Rev. Biochem. 59, 783-836   DOI   ScienceOn
5 Bociek, R. G. and Armitage, J. O. (1996). Hematopoietic growth factors. CA Cancer J. Clin. 46, 165-184   DOI   ScienceOn
6 Bokemeyer, C., Kuczyk, M. A., Kohne, H., Einsele, H., Kynast, B. and Schmoll, H. J. (1996). Hematopoietic growth factors and treatment of testicular cancer: biological interactions, routine use and dose-intensive chemotherapy. Ann. Hematol. 72, 1-9   DOI   ScienceOn
7 Browder, I. W. (1983). Role of immunomudulation in surgical infection. Surv. Immunol. Res. 2, 299-301
8 Brugger, W., Mocklin, W., Heimfeld, S., Berenson, R. J., Mertelsmann, R. and Kanz, L. (1994). Ex vivo expansion of enriched peripheral blood $CD34^+$ progenitor cells by stem cell factor, $interleukin-1{beta}(IL-1{beta})$, IL-6, IL-3, $interferon-{ gamma}$, and erythropoietin. Blood 81, 2579-2584
9 Cascinu, S. (1995). Management of diarrhea induced by tumors or cancer therapy. Curr. Opin. Oncol. 7, 325-329   DOI
10 Dexter, T. M., Allen, T. D. and Lajtha, L. G. (1997). Conditions controlling the proliferation of hematopoietic stem cells in vitro. J. Cell. Physiol. 91, 335-344
11 Hirose, K. and Matsushima, K. (1993). The biological significance of the induction of mangnanse superoxide dismutase by interleukine 1 and tumor mecrosis factor. Free Radic. Clin. Med. 7, 71
12 Ikegawa, T., Nakanishi, M., Uehara, N. and Chihara, G. (1968). Antitumor action of some basidomycetes, especially Phellinus linteus. Gann. 59, 155-157
13 Ito, I., Inoue, T., Miyaishi, K., Mitsuhashi, N., Kimura, M., Takahashi, I., Maehara, Y. and Niibe, H. (1979). Radiotherapy of the esophageal cancer: initial radiation effect and prognosis on the basis of radiographic findings and histological subclassification types of squamous cell carcinoma. Rinsho Hoshasen 24, 915-921
14 Pronk, L. C., Stoter, G. and Verweij, J. (1995). Docetaxel (Taxotere): single agent activity, development of combination treatment and reducing side-effects. Cancer Treat. Rev. 21, 463- 478   DOI
15 Jan, W., Visser-Dries, M. and Mulder, H. (1991). Culture of hematopoietic stem cell purified from murine bone marrow. Semin. Hematol. 28, 117-125
16 Kao, I., Kobayashi, S., Yokokura, T. and Mutai, M. (1981). Antitumor activity of Lactobacillys casei in mice. Gann. 72, 517- 523
17 Kim, H. M., Han, S. B., Oh, G. T., Kim, Y. H., Hong, D. H., Homg, N. D. and Yoo, I. D. (1996). Stimulation of humoral and cell mediated immunity by polysacchride from mushroom Phellinus linteus. Int. J. Immunopharmacol. 18, 295-303   DOI   ScienceOn
18 Pyo, M. Y., Hyun, S. M. and Yang, K. S. (2001). Effect of Phellinus linteus Extracts on the Humoral Immune Responsc in Normal and Cyclophosphamide-treated mice. J. Appl. Pharmcol. 9, 194-200
19 Rhee, Y. K., Han, M. J., Park, S. Y. and Kim, D. H. (2000). In vitro and in vivo antitumor activity of the fruit body of Phellinus linteus. Korea J. Food Sci. Technol. 32, 477-480   과학기술학회마을
20 Ridolfi, R., Flamini, E., Riccobon, A., De Paola, F., Maltoni, R., Gardini, A., Ridolfi, L., Medri, L., Poletti, G. and Amadori, D. (1998), Adjuvant adoptive immunotherapy with tumor-infiltrating lymphocytes and modulated doses of interleukin-2 in 22-patients with melanoma, colorectal and renal cancer, after radical metastasectomy, and in 12 advanced patients. Cancer Immunol. Immunother. 46, 185-193   DOI
21 Sugiura, M. and Ito, H. (1977). Toxicological studies of Ganderma lucidum Karst. Tokyo Yakakyu Daigaku Kenkyu Nempo 27. 722-725
22 Takeda, T., Shibata, S. and Fukuoka, F. (1969). Further investigation of the structure and the antitumor activity of the polysaccharides from Gyrophora esculenta and Lasallia papulosa. Chem. Pharm. Bull. 17, 1910-1916   DOI   ScienceOn
23 Clark, S. C. and Kamen, R. (1987). Hematopoietic growth factors as therapeutic agents. Science 236, 1229-1237   DOI
24 Chauvergne. J., Chinet-Charrot, P., Stockle, E., Thomas, L. and Toulouse, C. B. (1996). Carboplatin and etoposide combination for the treatment of recurrent epithelial ovarian cancer. Bull. Cancer 83, 315-323
25 Chihara, G., Hanuram, J., Maeda, Y., Arai, Y. and Fukuoka, F. (1969). Antitumor polysaccharide derive chemically from natural glucan (pachyman). Nature 225, 943-944   DOI   ScienceOn