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Cytotoxic Phenylpropanoids from the Rhizomes of Alpinia galanga  

NAM Joo-Won (College of Pharmacy, Ewha Womans University)
KIM Sun-Jack (College of Pharmacy, Ewha Womans University)
HAN Ah-Reum (College of Pharmacy, Ewha Womans University)
LEE Sang Kook (College of Pharmacy, Ewha Womans University)
SEO Eun-Kyoung (College of Pharmacy, Ewha Womans University)
Publication Information
Biomolecules & Therapeutics / v.13, no.4, 2005 , pp. 263-266 More about this Journal
Abstract
A bioassay-guided fractionation of the n-hexane and chloroform extracts of the rhizomes of Alpinia galanga led to the isolation of two active compounds, 1'S-1'-acetoxychavicol acetate (1) and p-coumaryl alcohol $\gamma$-O-methyl ether (2). 1'S-1'-acetoxychavicol acetate (1) exhibited significant cytotoxicity against all human cancer cell lines tested (A549; $IC_{50}$ 8.14, SNU 638; 1.27, HCTl16; 1.77, HT1080; 1.2, HL60; $IC_{50}$ 2.39 ${\mu}g/ml$), whereas p-coumaryl alcohol $\gamma$-O-methyl ether (2) showed selective cytotoxicity against the SNU638 cell ($IC_{50}$ = 1.62${\mu}g/ml$).
Keywords
Alpinia galanga; Zingiberaceae; cytotoxicity, l'S-l'-acetoxychavicol acetate;
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