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An Antimicrobial Activity of a Peptidic Molecule from the Centipede, Scolopendra subspinipes mutilans L. Koch  

Eun Jae Soon (College of Pharmacy, Woosuk University)
Leem Jae-Yoon (College of Pharmacy, Woosuk University)
Publication Information
Biomolecules & Therapeutics / v.13, no.4, 2005 , pp. 240-245 More about this Journal
Abstract
An antimicrobial molecule was purified from centipede, Scolopendra subspinipes mutilans L. Koch, by reverse phase-HPLC. Its molecular weight was determined to be 1208.5493 by using matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry. Total amino acid composition analysis revealed that it consists of E, G, P, V, L, F, and W. It exhibited a broad antimicrobial spectrum against not only Gram-negative, but also Gram-positive bacteria. Furthermore, it was found to have an antimicrobial activity against vancomycin resistant enterococci (VRE). It may be a useful molecule for a new antibiotic development, especially against drug-resistant bacteria. We suggest that it may playa role in the defense system of this animal. This is the first report of a peptidic antimicrobial substance from centipede.
Keywords
Peptidic antimicrobial substance; antibacterial activity; vancomycin resistant enterococci; Scolopendra subspinipes mutilans L. Koch.;
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