Chunghyuldan Downregulates the Activation of Transcription Factors NF - kB and AP-1 of BV-2 Cells Induced by Lipopolysaccharide |
WEE Sung-SooK
(College of Pharmacy, Kyung Hee University)
BAE Eun-Ah (College of Pharmacy, Kyung Hee University) PARK Jin-Sun (Department of Neuroscience, Ewha Womans University Medical School) KIM Hee-Sun (Department of Neuroscience, Ewha Womans University Medical School) CHo Hee Jae (Kwangdong Central Research Institute, Kwangdong Pharm. Co., Ltd,) Ryu Jong-Hoon (College of Pharmacy, Kyung Hee University) KIM Dong-Hyun (College of Pharmacy, Kyung Hee University) |
1 | Bocchini, V., Mazzolla, R, Barluzzi ,R, Blasi, E., Sick, P. and Kettenmann, H. (1992). An immortalized cell line expresses properties of activated microglial cells. J. Neurosci Res. 31, 616-621 DOI ScienceOn |
2 | Cho, K.H., Kim, Y.S., Bae, H.S., Moon, S.K., Jung, W.S., Park, E.K. and Kim D.H. (2004). Inhibitory effect of Chunghyuldan in prostaglandin E2 and nitric oxide biosynthesis of lipopolysaccharide-induced RAW 264.7 cells. Biol. Pharm. Bull. 27,1810-1813 DOI ScienceOn |
3 | Cho, K.H., Kang, H.S., Jung, W.S., Park, S.U. and Moon, S.K (2005). Efficacy and safety of Chunghyul-dan (qingwie-dan) in patients with hypercholesterolemia. Am. J. Chin. Med. 33, 241248 |
4 | Kim, W.K, Jang, P.G., Woo, M.S., Han, I.O., Pia, H.Z., Lee, K., Lee, H., Joh, T. and Kim H.S. (2004). A new anti-inflammatory agent KL-1037 represses proinflammatory cytokine and inducible nitric oxide synthase (iNOS) gene expression in activated microglia. Neuropharmacology 47, 243-252 DOI ScienceOn |
5 | Lennard, C.M., Mann, E.A, Sun, L.L., Chang, A.S. and Bolger W.E. (2000). Interleukin-1b, interleukin-5, interleukin-6, interleukin-8, and tumor necrosis factor-alpha in chronic sinusitis: response to systemic corticosteroids. Am. J. Rhinol. 14,367-73 DOI ScienceOn |
6 | Barber, P.A, Demchuk, A.M., and Hirt, L. Buchan A.M., (2003). Biochemistry of ischemic stroke. Adv. Neurol. 92, 151-164 |
7 | Bartosik-Psujek, H., Belniak, E. and Stelmasiak, Z. (2003) Markers of inflammation in cerebral ischemia. Neurol. Sci. 24, 279280 DOI ScienceOn |
8 | Dolan, S., Field, L.C. and Nolan, A.M. (2000). The role of nitric oxide and prostaglandin signaling pathways in spinal nociceptive processing in chronic inflammation. Pain 86, 311-320 DOI ScienceOn |
9 | Valles, S.L., Blanco, A.M., Pascual, M. and Guerri C. (2004). Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes. Brain Pathol. 14, 365-371 DOI ScienceOn |
10 | Appleton I., Tomlinsom A, Willoughby D.A, (1996). Induction of cyclo-oxygenase and nitric oxide synthase in inflammation. Adv. Pharmacol. 35, 27-78 DOI |
11 | Dubois, R.N., Abramson, S.B., Crofford, L., Gupta, R.A, Simon, L.S., Van De Putte, L.B.A. and Lipsky, P.E. (1998). Cyclooxygenase in biology and disease. FASEB J. 12, 1063-1073 DOI |
12 | Flora, G., Lee, Y.W., Nath, A, Maragos, W., Hennig, B. and Toborek, M. (2002). Methamphetamine-induced TNF-alpha gene expression and activation of AP-1 in discrete regions of mouse brain: potential role of reactive oxygen intermediates and lipid peroxidation. Neuromolecular Med. 2, 71-85 DOI ScienceOn |
13 | Ishihara, T., Kohno, K, Ushio, S., Iwaki, K, Ikeda, M. and Kurimoto, M. (2000). Tryptanthrin inhibits nitric oxide and prostaglandin E(2) synthesis by murine macrophages. Eur. J. Pharmacol. 407, 197-204 DOI ScienceOn |
14 | Jongeneel, C.V. (1995). Transcriptional regulation of the tumor necrosis factor alpha gene. lrnmunobiol. 193, 210-216 |
15 | Jung, W.S., Choi, D.J., Cho, K.H., Lee, K.S., Moon, S.K., Kim, Y.S. and Bae H.S. (2003). Safety and efficacy assessment of chungpyesagan-tang for acute ischemic stroke. Am. J. Chin. Med. 31,181-190 DOI ScienceOn |
16 | Perkins, D.J. and Kniss, D.A (1999) Blockade of nitric oxide formation down-regulates cyclooxygenase-2 and decreases PGE2. biosynthesis in macrophages. J. Leukoc. Biol. 65, 792-799 DOI |
17 | Lindsberg, P.J. and Grau A.J. (2003). Inflammation and infections as risk factors for ischemic stroke. Stroke 34, 2518-2532 DOI ScienceOn |
18 | Lowenstein, C.J., Alley, E.W, Rava, L.P., Snowman, A.M., Snyder, S.H., Russell, S.W and Murphy W.J. (1993). Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. Proc. Natl. Acad. Sci. USA 90, 9730-9734 |
19 | MacMicking, J., Xie, Q.W and Nathan, C. (1997). Nitric oxide and macrophage function. Ann. Rev. Immunol. 15, 323-350 DOI ScienceOn |
20 | Reynolds, M.A, Kirchick, H.J., Dahlen, J.R., Anderberg, J.M., McPherson, P.H., Nakamura, K.K, Laskowitz, D.T., VaIkirs, G.E. and Buechler K.F. (2003). Early biomarkers of stroke. Clin. Chem. 49, 1733-1739 DOI ScienceOn |
21 | Ryu, S.Y., Ock, M.H. and Kim K.M. (2000). Yomogin inhibits the degranulation of mast cells and the production of the nitric oxide in activated RAW 264.7 cells. Planta Med. 66, 171-173 DOI |
22 | Saleh A, Schroeter, M., Jonkrnanns, C., Hartung, H.P., Modder U. and Jander S. (2004). In vivo MRI of brain inflammation in human ischaemic stroke. Brain 127, 1670-1677 DOI ScienceOn |
23 | Stefanovic-Racic, S., Stadler, J. and Evans, C.H. (1993). Nitric oxide and arthritis. Arthritis Rheum. 36, 1036-1044 DOI ScienceOn |
24 | Smith, W.L., Garavito, R.M. and DeWitt, D.L. (1996). Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J. Biol. Chem. 271, 33157-33160 DOI ScienceOn |
25 | Chi, Y.S., Lim, H., Park, H. and Kim, H.P. (2003). Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Biochem. Pharmacol. 66, 1271-1278 DOI ScienceOn |
26 | Khan, M., Sekhon, B., Jatana, M., Giri, S., Gilg, AG., Sekhon, C; Singh, I. and Singh, A.K (2004). Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke. J. Neurosci. Res. 76, 519-27 DOI ScienceOn |
27 | Kim, Y.S., Jung, E.A, Shin, J.E., Chang, J.C, Yang, H.K., Kim, N.J., Cho, KH. and Kim, D.-H. (2002). Daio-Orengedokuto inhibits HMG-CoA reductase and pancreatic lipase. Biol. Pharm. Bull. 25, 1442-1445 DOI ScienceOn |