Browse > Article

Effect of Isoimperatorin on the Proliferation of Prostate Cancer Cell Line DU145 Cells  

Kang, Ja-Hoon (Department of Pharmacy, Sahmyook University)
Lee, Soo-Kyeon (Department of Pharmacy, Sahmyook University)
Yim, Dong-Sool (Department of Pharmacy, Sahmyook University)
Publication Information
Biomolecules & Therapeutics / v.13, no.3, 2005 , pp. 185-189 More about this Journal
Abstract
We isolated a coumarin compound, isoimperatorin ($C_{16}H_{14}O_4$ mw: 270) from Angelica koreana through silica gel column chromatography, and characterized it by NMR. Here, for the first time we observed that isoimperatorin (25, 50 and 100 ${\mu}M$) treatment for 24-72h inhibited growth and induced death in human prostate carcinoma DU145 cells. Further, in mechanistic investigation, isoimperatorin-induced cell growth inhibition was associated with a strong increase in G1 arrest in cell cycle progression, which started at 24h of the treatment. These findings suggest a novel anticancer efficacy of isoimperatorin mediated via induction of G1 arrest against hormone refractory human prostate carcinoma DU145 cells.
Keywords
isoimperatorin; Angelica koreana; prostate cancer (PCA); DU145 cells;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Bosland M. C., McCormick D. L., Melamed J. Walden P. D., Jacquotte AZ, Lumey LH. (2002). hemoprevention strategy for prostate cancer. Eur J. Cancer Chemoprev. 11, 18-27
2 Cai, Y., Baer-Dubowska, W., Aswood-Smith, M. and Digiovanni, J. (1997). Inhibitory effects of naturally occuring coumarins on the metabolic activation ofbenzo[a]pyrane and 7, 12-dimethylbenzo[a]anthracene in culured mouse keratocytes. Carcinogenesis 18, 215-222   DOI   ScienceOn
3 Cheng, L. Ricardo V. Lloyd, Amy L. Weaver, Thomas M. Pisansky, John C. Cheville, Dharamdas M. Ramnani, Bradley C. Leibovich, Michael L. Blute, Horst Zincke and David G. Bostwick, (2000). The cell cycle inhibitors p21/wafl and Kip/p27 are associated with survival in patients treated by salvage prostatectomy after radiation therapy. Clin Cancer Res. 6, 1896-1899
4 Chi, H. J., Kim, H.S. (1970). Pharmacological study of isoimperatorin and oxypeucedanin. Kor. J. Pharmac. 14, 21-27
5 Cho, J. Y., Lee, J. S., Park, J. S., Park M. H. (1998). Isolation of inhibitory components on tumor necrosis factor-a production from Angelica koreana. Yakhak Hoiji 42, 125-131
6 Choi, Y. E., Ahn, H., and Ryu, J., (2000). Polyacetylens from Angelica gigas and their inhibitory activity on nitric oxide synthesis in activated macrophage. Biol. Pharm. Bull., 23, 884-886   DOI   ScienceOn
7 Feldman B. J., Feldman D. (2001). The development of androgen-independent prostate cancer. Nat Rev Cancer. 1, 34-45   DOI   ScienceOn
8 Godley, P. A., Campbell, M. K., Gallagher, P., Martinson, F. E. A., Mohler, J. L., and Sandler, R. S. (1996). Biomarkers of essential fatty acid consumption and risk of prostate carcinoma. Cancer Epidemol. Biomark. Prev. 5, 889-895
9 Grana X., Reddy P. (1995). Cell Cycle control in mammalian cells : role of cyelins, cyelin-dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CDKIs). Oncogene 11, 211-219
10 Hunter, T., and Pines, J. (1994). Cyelins and cancer II : cyelin D and CDK inhibitors come of age. Cell 79, 573-582   DOI   ScienceOn
11 Jemal A, Thomas A, Murray T, et al. Cancer statistics. (2003). CA Cancer J Clin. 53, 5-26   DOI   ScienceOn
12 Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Robert JM, Tempst P, Massague J (1944). Cloning of Kip1/p27, cyelindependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 78, 59-66   DOI   ScienceOn
13 Shingh RP., Agarwal R. (2002). Phytochemicals as cell cyele modulators: a less tonic approach in halting human cancer. Cell Cycle 1, 156-161
14 Toyoshima H, Hunter T.(1994). p27, a novel inhibitor of G1 cyclin-CDK protein kinase activity, is related to p21. Cell 78, 67-74   DOI   ScienceOn
15 Xinong Y, Hannon G. J., Zhang H., Casso D., Kobayashi R, Beach D. (1993). p21 is a universal inhibitor of cyclin kinases. Nature 366, 701-704   DOI   ScienceOn
16 Yim, D. S., Shingh, R. P, Agarwal C., Lee, S. Y., Chi, H. J., and Agarwal, R. (2005). A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Research 65, 1035-1044
17 Morgan, D. O.(1995). Principles of CDK regulation. Nature 374, 131-134   DOI   ScienceOn
18 Oh, HC., Lee, HS., Kim TW., Chai, KY., Chung, HT., Kwon TO., Jun, JY., Jeong, OS., Kim YC, Yun, YG. (2002) Furocoumarins from Angelica dahurica with Hepatoprotective Activity on Tacrine-Induced Cytotoxicity in Hep G2 Cells. Planta Med. 68, 463-464   DOI   ScienceOn
19 Fujioka T, Furumi K, Fujii H, Okabe H, Mihashi K, Nakano Y, Matsunaga H, Katano M, Mori M., (1999). Antiproliferative constituents from umbelliferae plants. V. A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelicajaponica. Chem. Pharm. Bull. 47, 96-100   DOI   ScienceOn
20 Ross, R. K., and Henderson, B. E. (1994). Do diet and pathogens alter prostate cancer risk via a common ethiologic pathway? J. Natl. Cancer Inst. 86, 252-254   DOI   ScienceOn
21 Wall, M. E., Wani, M. C., Manikumar, G., Hyghes, T. J., Taylor, H., McGivney, R. and Warner, J. (1988). Plant antimutagenic agents, 3. Coumarins. J, Nat. Prod. 51, 1148-1152   DOI